{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T21:10:09Z","timestamp":1710191409703},"reference-count":29,"publisher":"Akademiai Kiado Zrt.","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:p>A vastagb\u00e9l stromasejtjeinek \u00e9s az azokat k\u00f6r\u00fclvev\u0151 mikrok\u00f6rnyezetnek els\u0151dleges szerepe van a gyullad\u00e1sos folyamatok szab\u00e1lyoz\u00e1s\u00e1ban, a tumorok kialak\u00edt\u00e1s\u00e1ban \u00e9s az \u00e1tt\u00e9tek k\u00e9pz\u00e9s\u00e9ben. A gyullad\u00e1sos folyamatokban \u00e9s az azt k\u00f6vet\u0151 sz\u00f6veti regener\u00e1ci\u00f3ban\u00a0alapvet\u0151 jelent\u0151s\u00e9g\u0171ek a myofibroblastok, amelyek \u00e1ltal termelt molekul\u00e1k hatnak az immunrendszer sejtjeire \u00e9s a h\u00e1msejtek prolifer\u00e1ci\u00f3j\u00e1ra. A daganatok myofibroblastokat aktiv\u00e1lhatnak, amelyek fokozott \u00e9s megv\u00e1ltozott regul\u00e1toros ligand (citokin, kemokin, kemotaktikus \u00e9s n\u00f6veked\u00e9si faktorok) termel\u00e9se \u0151ssejt-aktiv\u00e1ci\u00f3n kereszt\u00fcl a h\u00e1msejtek kontroll\u00e1latlan szaporod\u00e1s\u00e1hoz vezethet. Dolgozatunkban a myofibroblastokkal kapcsolatos tudnival\u00f3kat foglaljuk \u00f6ssze, \u00e9s ismertetj\u00fck szerep\u00fcket a gyullad\u00e1sos \u00e9s a neoplasztikus folyamatokban.<\/jats:p>","DOI":"10.1556\/oh.2009.28573","type":"journal-article","created":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T01:01:45Z","timestamp":1237338105000},"page":"597-602","source":"Crossref","is-referenced-by-count":0,"title":["Role of myofibroblast in inflammatory bowel disease and tumor genesis"],"prefix":"10.1556","volume":"150","author":[{"given":"G\u00e1bor","family":"Valcz","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Kren\u00e1cs","sequence":"additional","affiliation":[{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. 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