{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:13:23Z","timestamp":1785464003765,"version":"3.56.0"},"reference-count":73,"publisher":"Akademiai Kiado Zrt.","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:p>Az eml\u0151r\u00e1k a n\u0151k leggyakoribb r\u00e1kos megbeteged\u00e9se. \u00c9vente t\u00f6bb mint egymilli\u00f3 n\u0151 betegszik meg eml\u0151r\u00e1kban. Az eml\u0151r\u00e1kos morbidit\u00e1s meredeken emelkedett a fejlett ipari orsz\u00e1gokban az ut\u00f3bbi p\u00e1r \u00e9vtizedben, de a mortalit\u00e1si r\u00e1ta mostan\u00e1ban cs\u00f6kken. Az ut\u00f3bbi a szervezett lakoss\u00e1gi sz\u0171r\u00e9seknek, a korszer\u0171 seb\u00e9szi \u00e9s sug\u00e1rter\u00e1pi\u00e1s beavatkoz\u00e1soknak \u00e9s a hat\u00e9konyabb sziszt\u00e9m\u00e1s kezel\u00e9seknek k\u00f6sz\u00f6nhet\u0151. A fejl\u0151d\u00e9s egyik legizgalmasabb ter\u00fclete az \u00faj ter\u00e1pi\u00e1s szerek bevezet\u00e9se a klinikai gyakorlatba. A c\u00e9lzott ter\u00e1pia (tirozinkin\u00e1zok g\u00e1tl\u00e1sa) rohamosan fejl\u0151dik. Korai (0.\/I.\/II. st\u00e1dium) eml\u0151r\u00e1kban a daganatot m\u0171t\u00e9ttel elt\u00e1vol\u00edtj\u00e1k, \u00e9s ezt k\u00f6veti az adjuv\u00e1ns kezel\u00e9s. Az adjuv\u00e1ns kezel\u00e9s c\u00e9lja a lokoregion\u00e1lis \u00e9s t\u00e1voli mikroszkopikus daganatdepozitok elpuszt\u00edt\u00e1sa. A\u00a0daganatos ki\u00fajul\u00e1s kock\u00e1zat\u00e1nak megbecs\u00fcl\u00e9s\u00e9re prognosztikai faktorokat haszn\u00e1lunk. Az optim\u00e1lis individualiz\u00e1lt kezel\u00e9s meghat\u00e1roz\u00e1s\u00e1t a predikt\u00edv faktorok seg\u00edtik. A dolgozatban a korai eml\u0151r\u00e1k kezel\u00e9s\u00e9nek jelenlegi helyzet\u00e9t t\u00e1rgyaljuk, bele\u00e9rtve az eml\u0151megtart\u00f3 kezel\u00e9st, a mastectomia ut\u00e1ni sug\u00e1rkezel\u00e9st, a hormon- \u00e9s kemoter\u00e1pi\u00e1t, valamint a hum\u00e1n epiderm\u00e1lis n\u00f6veked\u00e9si faktor receptor-2- (HER-2-) pozit\u00edv daganatok trastuzumabkezel\u00e9s\u00e9t.<\/jats:p>","DOI":"10.1556\/oh.2009.28615","type":"journal-article","created":{"date-parts":[[2009,5,23]],"date-time":"2009-05-23T01:03:46Z","timestamp":1243040626000},"page":"1013-1021","source":"Crossref","is-referenced-by-count":15,"title":["Current status of treatment for early-stage invasive breast cancer"],"prefix":"10.1556","volume":"150","author":[{"given":"Mikl\u00f3s","family":"K\u00e1sler","sequence":"first","affiliation":[{"name":"1 Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet Budapest R\u00e1th Gy. u. 7\u20139. 1122"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Polg\u00e1r","sequence":"additional","affiliation":[{"name":"1 Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet Budapest R\u00e1th Gy. u. 7\u20139. 1122"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Fodor","sequence":"additional","affiliation":[{"name":"1 Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet Budapest R\u00e1th Gy. u. 7\u20139. 1122"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3322\/CA.2007.0010","volume":"58","year":"2008","journal-title":"CA Cancer J. 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