{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:42:56Z","timestamp":1784947376008,"version":"3.55.0"},"reference-count":36,"publisher":"Akademiai Kiado Zrt.","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:p>A metabolikus szindr\u00f3ma jellemz\u0151i a hasi elh\u00edz\u00e1s, a magas v\u00e9rnyom\u00e1s, az \u00e9hhomi gl\u00fck\u00f3z \u00e9s dyslipidaemia egy\u00fcttes el\u0151fordul\u00e1sa. A\u00a0vizsg\u00e1lat c\u00e9lja, hogy felt\u00e1rja a metabolikus anyagcserezavar \u00e9s egyes terhess\u00e9gi sz\u00f6v\u0151dm\u00e9nyek kapcsolat\u00e1t. \n <jats:italic>Anyag \u00e9s m\u00f3dszer:<\/jats:italic>\n A relev\u00e1ns k\u00f3dok alapj\u00e1n retrospekt\u00edve lev\u00e1logatott digit\u00e1lis adatb\u00e1zisb\u00f3l a 2005\u20132008 k\u00f6z\u00f6tti vizsg\u00e1lt id\u0151szakban (4 \u00e9v) a k\u00f3rh\u00e1zi dokument\u00e1ci\u00f3kban 5869 v\u00e1rand\u00f3s anya gondoz\u00e1si adataival rendelkeztek. Sz\u00e1zhetvenkett\u0151 anya (2,9%) eset\u00e9ben a v\u00e1rand\u00f3ss\u00e1guk els\u0151 harmad\u00e1ban a metabolikus t\u00fcnetegy\u00fcttes jellemz\u0151i szerepeltek. Ezen betegek adatait r\u00e9szletesen megvizsg\u00e1lt\u00e1k, feldolgozt\u00e1k \u00e9s relev\u00e1ns adataikat a t\u00f6bbi v\u00e1rand\u00f3s hasonl\u00f3 dokument\u00e1ci\u00f3ival \u00f6sszehasonl\u00edtott\u00e1k. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n A metabolikus t\u00fcnetegy\u00fcttes t\u00fcneteit\u00a0mutat\u00f3 csoportban a korasz\u00fcl\u00e9si ar\u00e1ny 15,1% (26\/172) volt, m\u00edg a metabolikus szindr\u00f3m\u00e1t\u00f3l mentes esetekben az id\u0151 el\u0151tti sz\u00fclet\u00e9s csup\u00e1n 11,7% volt [OR: 1,52 (95%-os CI: 0,996\u20132,33) p=0,051]. Az anyagcserezavarban \u00e9rintettek csoportj\u00e1ban 32 any\u00e1n\u00e1l intrauterin n\u00f6veked\u00e9si zavart \u00e9szleltek, m\u00edg ezen t\u00fcnetegy\u00fcttes n\u00e9lk\u00fcli esetekben ez csup\u00e1n 3,6%-ban (205\/5697) fordult el\u0151 [OR: 6,38 (95%-os CI: 4,24\u20139,61) p&lt;0,001)]. A vizsg\u00e1lt csoportban 47 praeeclampsi\u00e1val sz\u00f6v\u0151d\u00f6tt v\u00e1rand\u00f3ss\u00e1got \u00e9szleltek (27,3%), szemben a beteganyaguk tov\u00e1bbi r\u00e9sz\u00e9vel, ahol a terhess\u00e9gi m\u00e9rgez\u00e9s el\u0151fordul\u00e1sa 4,7% volt [OR: 7,93 (95%-os CI: 5,54\u201311,33) p&lt;0,001]. A metabolikus t\u00fcnetegy\u00fcttesben szenved\u0151k k\u00f6r\u00e9ben 67 (38,2%) olyan beteg volt, aki t\u00f6bb mint egy, a betegs\u00e9gre jellemz\u0151 sz\u00fcl\u00e9szeti sz\u00f6v\u0151dm\u00e9nyben szenvedett. A kontrollcsoportban ugyanez az ar\u00e1ny 17,0%-nak ad\u00f3dott [OR: 3,11 (2,27\u20134,26) p&lt;0,001]. A metabolikus szindr\u00f3ma \u00e1ltal \u00e9rintett csoportban csup\u00e1n 47 (27,3%) olyan esetet tal\u00e1ltak, akik v\u00e1rand\u00f3ss\u00e1guk \u00e9s sz\u00fcl\u00e9s\u00fck alatt t\u00fcnetmentesek voltak, m\u00edg az 5697 any\u00e1b\u00f3l, akikn\u00e9l az els\u0151 terhess\u00e9gi harmadban a metabolikus t\u00fcnetegy\u00fcttes jeleit nem \u00e9szlelt\u00e9k, szignifik\u00e1nsan kedvez\u0151bb ar\u00e1nyban (74,1%, 4220 v\u00e1rand\u00f3s) voltak olyan any\u00e1k, akik minden sz\u00f6v\u0151dm\u00e9ny n\u00e9lk\u00fcl viselt\u00e9k v\u00e1rand\u00f3ss\u00e1gukat [OR: 0,132 (0,09\u20130,18) p&lt;0,001]. \n <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>\n A metabolikus szindr\u00f3ma irodalmi adatok alapj\u00e1n \u00e9s saj\u00e1t megfigyel\u00e9seik szerint is jelent\u0151s szerepet j\u00e1tszik a sz\u00f6v\u0151dm\u00e9nyes v\u00e1rand\u00f3ss\u00e1gok kialakul\u00e1s\u00e1ban, els\u0151sorban a gyullad\u00e1sos faktorok \u00e9s a fokozott tromb\u00f3zisk\u00e9szs\u00e9g provok\u00e1l\u00e1s\u00e1val. Sz\u00e1mos irodalmi adat utal arra, hogy a metabolikus t\u00fcnetegy\u00fcttes eset\u00e9n a m\u00e1r a koncepci\u00f3 idej\u00e9n alkalmazott heparinkezel\u00e9s eredm\u00e9nyes lehet. 2007-ben prospekt\u00edv vizsg\u00e1latot ind\u00edtottak azzal a c\u00e9llal, hogy megismerj\u00e9k, vajon az alacsony molekulat\u00f6meg\u0171 heparin megel\u0151z\u0151 c\u00e9l\u00fa kezel\u00e9s, seg\u00edt-e elker\u00fclni ennek az anyagcserezavarnak a kedvez\u0151tlen k\u00f6vetkezm\u00e9nyeit? Rem\u00e9nyeik szerint a 2010-es \u00e9vekt\u0151l a heparinkezel\u00e9s eredm\u00e9nyeir\u0151l adatokkal rendelkeznek.<\/jats:p>","DOI":"10.1556\/oh.2009.28632","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T01:15:38Z","timestamp":1247188538000},"page":"1361-1365","source":"Crossref","is-referenced-by-count":8,"title":["The metabolic syndrome and the risks of unfavourable outcome of pregnancy"],"prefix":"10.1556","volume":"150","author":[{"given":"Boldizs\u00e1r","family":"Horv\u00e1th","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"Riba","sequence":"additional","affiliation":[{"name":"1 Vas Megyei Markusovszky K\u00f3rh\u00e1z Nonprofit Zrt. 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Med."},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/diacare.21.9.1414","volume":"21","year":"1998","journal-title":"Diabetes Care"},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/01.CIR.0000111245.75752.C6","volume":"109","year":"2004","journal-title":"Circulation"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1097\/PSY.0b013e318183a491","volume":"70","year":"2008","journal-title":"Psychosom. Med."},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1001\/jama.282.16.1519","volume":"282","year":"1999","journal-title":"JAMA"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1056\/NEJM198610163151609","volume":"315","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"atypb8","first-page":"11","volume":"78","year":"1974","journal-title":"Acta Endocinol. (Copenh)"},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/j.1550-8528.1993.tb00614.x","volume":"1","year":"1993","journal-title":"Obes. Res."},{"key":"atypb10","first-page":"80","volume":"170","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0027-9684(15)31444-9","volume":"100","year":"2008","journal-title":"J. National Med. Assoc."},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1161\/01.HYP.0000120122.39231.88","volume":"43","year":"2004","journal-title":"Hypertension"},{"key":"atypb13","first-page":"250","volume":"3","year":"2008","journal-title":"Metabolic syndrome and related disorders"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/jn\/133.5.1674S","volume":"133","year":"2003","journal-title":"J. Nutr."},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/35007508","volume":"404","year":"2000","journal-title":"Nature"},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1055\/s-0037-1616938","volume":"29","year":"2009","journal-title":"H\u00e4mostaseologie"},{"key":"atypb17","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1001\/jama.287.3.356","volume":"287","year":"2002","journal-title":"JAMA"},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00000441-200512000-00003","volume":"330","year":"2005","journal-title":"Am. J. Med. Sci."},{"key":"atypb19","first-page":"155","volume":"5","year":"2004","journal-title":"Current Opinion in Pharmacol."},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2141.2007.06780.x","volume":"139","year":"2007","journal-title":"Br. J. Haematol."},{"key":"atypb21","first-page":"1595","volume":"37","year":"1989","journal-title":"Diabetes"},{"key":"atypb22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1023\/A:1023241130459","volume":"14","year":"2002","journal-title":"J. Thromb. Thrombolysis"},{"key":"atypb23","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/qjmed\/hcm083","volume":"100","year":"2007","journal-title":"Q. J. Med."},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1111\/j.1538-7836.2006.02132.x","volume":"4","year":"2006","journal-title":"J. Throm. Haemost."},{"key":"atypb25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ejogrb.2007.06.011","volume":"137","year":"2008","journal-title":"Europ. J. Obstet. Gynecol. and Reprod. Biol."},{"key":"atypb26","unstructured":"Visser G. H. A.Obesity, gestational diabetes and pregnancy outcomeSeminars in Fetal and Neonatal Medicine2008"},{"key":"atypb27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1542\/peds.2004-1808","volume":"115","year":"2005","journal-title":"Pediatrics"},{"key":"atypb28","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1345\/aph.17084","volume":"32","year":"1998","journal-title":"Ann. Pharmacol."},{"key":"atypb29","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1161\/01.CIR.0000052617.91920.FD","volume":"107","year":"2003","journal-title":"Circulation"},{"key":"atypb30","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S1701-2163(16)30391-7","volume":"27","year":"2005","journal-title":"J. Obstet. Cynecol.Can."},{"key":"atypb31","first-page":"268","volume":"97","year":"2001","journal-title":"Obstet. Gynecol."},{"key":"atypb32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2105\/AJPH.2005.074294","volume":"97","year":"2007","journal-title":"Am. J. Public. Health"},{"key":"atypb33","first-page":"168","volume":"24","year":"2007","journal-title":"BMC Public Health"},{"key":"atypb34","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1160\/TH07-11-0682","volume":"99","year":"2008","journal-title":"Thrombos. Haemost."},{"key":"atypb35","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1161\/01.CIR.0000089505.34741.E5","volume":"108","year":"2003","journal-title":"Circulation"},{"key":"atypb36","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S0002-9378(97)70004-8","volume":"177","year":"1997","journal-title":"Am. J.\u00a0Obstet. Gynecol."},{"key":"atypb37","first-page":"333","volume":"18","year":"2001","journal-title":"Biabet. 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