{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T10:41:24Z","timestamp":1649068884999},"reference-count":15,"publisher":"Akademiai Kiado Zrt.","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:p>A dystoni\u00e1k f\u0151 jellemz\u0151je a tart\u00f3s izomg\u00f6rcs\u00f6k kialakul\u00e1sa. Ezek csavar\u00f3 \u00e9s folyamatosan ism\u00e9tl\u0151d\u0151 mozg\u00e1sokat okoznak, vagy k\u00f3ros tart\u00e1s kialakul\u00e1s\u00e1hoz vezetnek. Kezel\u00e9s\u00fck gy\u00f3gyszerrel, m\u0171t\u00e9ti \u00faton, botulinum toxin injekci\u00f3val \u00e9s egy\u00e9b, kieg\u00e9sz\u00edt\u0151 elj\u00e1r\u00e1sokkal t\u00f6rt\u00e9nhet. A szerz\u0151k 1991 \u00f3ta alkalmazz\u00e1k a botulinum toxin kezel\u00e9st. \n <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n A szerz\u0151k azt vizsg\u00e1lt\u00e1k, mennyire hat\u00e9kony \u00e9s biztons\u00e1gos a botulinum toxin alkalmaz\u00e1sa fok\u00e1lis dystoni\u00e1k \u00e9s hemifacialis spasmus eset\u00e9n. \n <jats:italic>M\u00f3dszer:<\/jats:italic>\n Kilencvenn\u00e9gy beteget vizsg\u00e1ltak, \u00e1tlag\u00e9letkor 62,4 \u00e9v, a kezel\u00e9s \u00e1tlagos ideje 6,8 \u00e9v. A betegek megoszl\u00e1sa a dystonia t\u00edpusa szerint a k\u00f6vetkez\u0151: torticollis spastica 33 f\u0151, blepharospasmus 32 f\u0151, hemifacialis spasmus 29 f\u0151. A kezel\u00e9s A t\u00edpus\u00fa botulinum toxin injekci\u00f3val t\u00f6rt\u00e9nt. A kezel\u00e9s hat\u00e1s\u00e1t a Patient Global Impression sk\u00e1l\u00e1val m\u00e9rt\u00e9k. Emellett elemezt\u00e9k a mell\u00e9khat\u00e1sokat, a sz\u00f6v\u0151dm\u00e9nyeket \u00e9s a kezel\u00e9s megszak\u00edt\u00e1s\u00e1nak az okait. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n A botulinum toxin kezel\u00e9s 92%-ban volt hat\u00e1sos. Ezen bel\u00fcl klinikailag jelent\u0151s javul\u00e1st a betegek 56%-a \u00e9rt el. A hat\u00e1soss\u00e1g tekintet\u00e9ben nem volt statisztikai k\u00fcl\u00f6nbs\u00e9g sem a dystoni\u00e1k t\u00edpusai (torticollis spastica 87%, blepharospasmus 93% \u00e9s hemifacialis spasmus 96%), sem az alkalmazott k\u00e9sz\u00edtm\u00e9nyek k\u00f6z\u00f6tt (Botox 92%, Dysport 92%). Hat betegn\u00e9l fordult el\u0151 \u00e1tmeneti gyenges\u00e9g. Jelent\u0151s mell\u00e9khat\u00e1st vagy sz\u00f6v\u0151dm\u00e9nyt nem \u00e9szlelt\u00fcnk. \n <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>\n A vizsg\u00e1lat eredm\u00e9nyei azt igazolj\u00e1k, hogy a botulinum toxin injekci\u00f3 hat\u00e9kony \u00e9s biztons\u00e1gos kezel\u00e9s torticollis spastica, blepharospasmus \u00e9s hemifacialis spasmus eset\u00e9n.<\/jats:p>","DOI":"10.1556\/oh.2009.28640","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T01:15:38Z","timestamp":1247188538000},"page":"1381-1384","source":"Crossref","is-referenced-by-count":0,"title":["Botulinum toxin therapy for focal dystonia"],"prefix":"10.1556","volume":"150","author":[{"given":"Katalin","family":"Hahn","sequence":"first","affiliation":[{"name":"1 Vas Megyei Markusovszky K\u00f3rh\u00e1z Nonprofit Zrt. Neurol\u00f3giai Oszt\u00e1ly Szombathely Markusovszky utca 3. 9700"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet","family":"Niklai","sequence":"additional","affiliation":[{"name":"2 Vas Megyei Markusovszky K\u00f3rh\u00e1z Nonprofit Zrt. K\u00f6zponti Rehabilit\u00e1ci\u00f3s Oszt\u00e1ly Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Garzuly","sequence":"additional","affiliation":[{"name":"3 Vas Megyei Markusovszky K\u00f3rh\u00e1z Nonprofit Zrt. Patol\u00f3giai Oszt\u00e1ly Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Szupera","sequence":"additional","affiliation":[{"name":"1 Vas Megyei Markusovszky K\u00f3rh\u00e1z Nonprofit Zrt. 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