{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:16:45Z","timestamp":1785363405076,"version":"3.55.0"},"reference-count":7,"publisher":"Akademiai Kiado Zrt.","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:p>\n          <jats:italic>Esetismertet\u00e9s<\/jats:italic>\n : Genetikai tan\u00e1csad\u00f3nkban egy 47 \u00e9ves, komplex v\u00e9gtaghi\u00e1nyos rendelleness\u00e9gben szenved\u0151 n\u0151 jelentkezett \u00e9s szakv\u00e9lem\u00e9nyben k\u00e9rte annak igazol\u00e1s\u00e1t, hogy v\u00e9gtaghi\u00e1nyos rendelleness\u00e9g\u00e9t a thalidomid (Contergan) nev\u0171 gy\u00f3gyszer okozta. \u00c9desanyja az \u0151 sz\u00fclet\u00e9s\u00e9vel v\u00e9gz\u0151d\u0151 terhess\u00e9g\u00e9ben \u00e1ll\u00edt\u00f3lag szedte ezt a gy\u00f3gyszert, amit Nyugat-N\u00e9metorsz\u00e1gban \u00e9l\u0151 n\u0151v\u00e9r\u00e9t\u0151l kapott. A thalidomid radialis-tibialis t\u00edpus\u00fa v\u00e9gtaghi\u00e1nyos rendelleness\u00e9get id\u00e9z el\u0151, amely gyakran t\u00e1rsul f\u00fclkagyl\u00f3- \u00e9s m\u00e1s rendelleness\u00e9gekkel. A thalidomidra jellemz\u0151 v\u00e9gtaghi\u00e1nyos \u00e9s m\u00e1s fejl\u0151d\u00e9si rendelleness\u00e9g azonban n\u00e1la nem volt \u00e9szlelhet\u0151. A n\u0151 komplex v\u00e9gtag-rendelleness\u00e9ge az \u00fagynevezett FFU-komplexnek felelt meg, mivel femurhypoplasia (F), fibulahypoplasia (F) az V. \u00e9s IV.\u00a0l\u00e1bujj hi\u00e1ny\u00e1val mindk\u00e9t als\u00f3 v\u00e9gtagj\u00e1n, valamint ulnaris hypoplasia (U) az V. \u00e9s IV. ujj hi\u00e1ny\u00e1val a jobb fels\u0151 v\u00e9gtagon volt \u00e9szlelhet\u0151, m\u00e1s fejl\u0151d\u00e9si rendelleness\u00e9g n\u00e9lk\u00fcl. Emellett schizophrenia miatt kezelt\u00e9k. \u00cdgy az a kor\u00e1bban elfogadott felt\u00e9telez\u00e9s, hogy v\u00e9gtaghi\u00e1nyos rendelleness\u00e9g\u00e9t a thalidomid okozta, kiz\u00e1rhat\u00f3 volt.<\/jats:p>","DOI":"10.1556\/oh.2009.28641","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T01:03:36Z","timestamp":1244163816000},"page":"1179-1181","source":"Crossref","is-referenced-by-count":1,"title":["Thalidomide (Contergan) induced limb deficiency in Hungary?"],"prefix":"10.1556","volume":"150","author":[{"given":"J\u00e1nos","family":"Gidai","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"B\u00e1cs","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre","family":"Czeizel","sequence":"additional","affiliation":[{"name":"2 Budapest II. Ker\u00fcleti \u00d6nkorm\u00e1nyzat Eg\u00e9szs\u00e9g\u00fcgyi Szolg\u00e1lat R\u00f6ntgen \u00e9s \u201eGenetikai \u00c1rtalmak T\u00e1rsadalmi Megel\u0151z\u00e9se\u201d Alap\u00edtv\u00e1ny Budapest T\u00f6r\u00f6kv\u00e9sz lejt\u0151 32. 1026"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"atypb1","volume-title":"Congenital limb deficiencies in Hungary","year":"1994"},{"key":"atypb2","first-page":"244","volume":"3","year":"1967","journal-title":"Humangenetik"},{"key":"atypb3","first-page":"347","volume":"91","year":"1993","journal-title":"Hum. Genet."},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ajmg.1320460416","volume":"46","year":"1993","journal-title":"Am. J. Med. Genet."},{"key":"atypb5","first-page":"271","year":"1962","journal-title":"Lancet"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1055\/s-0028-1111892","volume":"87","year":"1962","journal-title":"Dtsch. Med. Wschr."},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/tera.1420460505","volume":"46","year":"1992","journal-title":"Teratology"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/150\/25\/article-p1179.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/150\/25\/article-p1179.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T10:17:23Z","timestamp":1590574643000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/150\/25\/article-p1179.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,1]]},"references-count":7,"journal-issue":{"issue":"25"},"URL":"https:\/\/doi.org\/10.1556\/oh.2009.28641","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,1]]}}}