{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T20:23:58Z","timestamp":1694636638989},"reference-count":10,"publisher":"Akademiai Kiado Zrt.","issue":"28","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"abstract":"<jats:p>A Whipple-k\u00f3r egy kr\u00f3nikus, sziszt\u00e9m\u00e1s, relapsusokkal k\u00eds\u00e9rt, kezel\u00e9s n\u00e9lk\u00fcl hal\u00e1los kimenetel\u0171 bakteri\u00e1lis megbeteged\u00e9s, amely jelent\u0151s diagnosztikus kih\u00edv\u00e1st jelent mind a klinikusok, mind a patol\u00f3gusok sz\u00e1m\u00e1ra. A betegs\u00e9g az esetek 80%-\u00e1ban a k\u00f6z\u00e9pkor\u00fa, feh\u00e9r, kauk\u00e1zusi f\u00e9rfiakat \u00e9rinti.<jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>A szerz\u0151k h\u00e1rom eset kapcs\u00e1n mutatnak r\u00e1 a k\u00f3rk\u00e9p diagnosztik\u00e1j\u00e1nak neh\u00e9zs\u00e9geire, valamint irodalmi \u00e1ttekint\u00e9st adnak a betegs\u00e9g etiol\u00f3gi\u00e1j\u00e1r\u00f3l, klinikum\u00e1r\u00f3l, felt\u00e9telezett patomechanizmus\u00e1r\u00f3l, valamint a kezel\u00e9s lehet\u0151s\u00e9geir\u0151l.<jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>A k\u00f3rk\u00e9p kialakul\u00e1s\u00e1ban immunol\u00f3giai t\u00e9nyez\u0151k j\u00e1tszanak szerepet, azonban m\u00e9g nem tiszt\u00e1zott azok primer vagy szekunder jellege. Els\u0151sorban a b\u00e9lrendszer betegs\u00e9ge, azonban az extraintestinalis t\u00fcnetek gyakran \u00e9vekkel, \u00e9vtizedekkel megel\u0151zik az intestinalis t\u00fcnetek megjelen\u00e9s\u00e9t \u00e9s a diagn\u00f3zis fel\u00e1ll\u00edt\u00e1s\u00e1t. A betegs\u00e9g igazol\u00e1s\u00e1nak klasszikus eszk\u00f6ze a v\u00e9konyb\u00e9l-biopszi\u00e1s mint\u00e1k perj\u00f3dsav-Schiff fest\u00e9se, valamint a k\u00f3rokoz\u00f3 polimer\u00e1z l\u00e1ncreakci\u00f3val t\u00f6rt\u00e9n\u0151 igazol\u00e1sa. A megfelel\u0151 antibiotikum kiv\u00e1laszt\u00e1sa \u00e9s a ter\u00e1pia id\u0151tartama empirikus, azonban a kezel\u00e9sre a legt\u00f6bb esetben azonnali v\u00e1lasz k\u00f6vetkezik be. A relapsusok k\u00fcl\u00f6n\u00f6sen k\u00f6zponti idegrendszeri \u00e9rintetts\u00e9g eset\u00e9n gyakoriak.<\/jats:p>","DOI":"10.1556\/oh.2009.28668","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T01:15:43Z","timestamp":1247188543000},"page":"1313-1319","source":"Crossref","is-referenced-by-count":0,"title":["Whipple\u2019s disease. 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