{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T10:28:32Z","timestamp":1649068112397},"reference-count":30,"publisher":"Akademiai Kiado Zrt.","issue":"44","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,1]]},"abstract":"<jats:p>Magyarorsz\u00e1gon 1993 \u00e9s 2006 k\u00f6z\u00f6tt a sz\u00fclet\u00e9skor v\u00e1rhat\u00f3 \u00e9lettartam 4,14 \u00e9vvel n\u0151tt, \u00e9s ehhez a cardiovascularis haland\u00f3s\u00e1g javul\u00e1sa 1,85 \u00e9vvel j\u00e1rult hozz\u00e1. A lipidszintcs\u00f6kkent\u0151 kezel\u00e9s, a lipidc\u00e9l\u00e9rt\u00e9kek el\u00e9r\u00e9se az ut\u00f3bbi \u00e9vekben a cardiovascularis prevenci\u00f3 egyik s\u00falyponti k\u00e9rd\u00e9se lett. A javul\u00f3 tendencia ellen\u00e9re az LDL-koleszterin-szint c\u00e9l\u00e9rt\u00e9k\u00e9nek el\u00e9r\u00e9si ar\u00e1nya nem nagyobb egyharmadn\u00e1l, \u00e9s ebben legink\u00e1bb az j\u00e1tszik szerepet, hogy a nem megfelel\u0151 szint\u0171 lipidcs\u00f6kkent\u00e9st igazol\u00f3 eredm\u00e9nybe az orvosok nagyobb r\u00e9sze (2007-ben 56%-a) belet\u00f6r\u0151dik, nem igyekszik m\u00f3dos\u00edtani a kezel\u00e9sen, pedig egyre t\u00f6bb adat igazolja, hogy az alacsonyabb LDL-koleszterin-szint el\u00e9r\u00e9se nemcsak a klinikai kimenetelt jav\u00edtja szignifik\u00e1nsan, hanem k\u00f6lts\u00e9ghat\u00e9kony is. Az ut\u00f3bbi id\u0151szak legjelent\u0151sebb, statinnal v\u00e9gzett \u00faj vizsg\u00e1lata a JUPITER, amely lipidszintjeik miatt statinkezel\u00e9st nem ig\u00e9nyl\u0151, magas hs-CRP-szint\u0171, nem ismert \u00e9rbetegeken igazolta, hogy 20 mg rosuvastatin ad\u00e1s\u00e1val szignifik\u00e1nsan, 44%-kal cs\u00f6kkenthet\u0151 a primer v\u00e9gpont (a cardiovascularis hal\u00e1loz\u00e1s, nem hal\u00e1los stroke \u00e9s sz\u00edvinfarktus, instabil angina vagy revascularisatio) \u00e9s 20%-kal az \u00f6sszhal\u00e1loz\u00e1s el\u0151fordul\u00e1sa. Egy primer v\u00e9gpont megel\u0151z\u00e9s\u00e9hez 23 beteg 5 \u00e9ves kezel\u00e9se sz\u00fcks\u00e9ges. Az eredm\u00e9nyek felvetik a primer prevenci\u00f3 elvei \u00e9s c\u00e9l\u00e9rt\u00e9kei \u00e1tgondol\u00e1s\u00e1nak sz\u00fcks\u00e9gess\u00e9g\u00e9t, valamint azt, hogy minden lipidcs\u00f6kkent\u0151 kezel\u00e9sben nagyobb figyelmet kellene ford\u00edtani a betegek hs-CRP szintj\u00e9re.<\/jats:p>","DOI":"10.1556\/oh.2009.28740","type":"journal-article","created":{"date-parts":[[2009,10,28]],"date-time":"2009-10-28T01:05:33Z","timestamp":1256691933000},"page":"2012-2018","source":"Crossref","is-referenced-by-count":1,"title":["From lipid target values to JUPITER study. Importance of the achievement of lipid levels specified by the guidelines and deficiencies in the present practice"],"prefix":"10.1556","volume":"150","author":[{"given":"L\u00e1szl\u00f3","family":"M\u00e1rk","sequence":"first","affiliation":[{"name":"1 B\u00e9k\u00e9s Megyei K\u00e9pvisel\u0151-test\u00fclet P\u00e1ndy K\u00e1lm\u00e1n K\u00f3rh\u00e1z II. Belgy\u00f3gy\u00e1szat-Kardiol\u00f3gia Gyula Semmelweis u. 1. 5700"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Katona","sequence":"additional","affiliation":[{"name":"1 B\u00e9k\u00e9s Megyei K\u00e9pvisel\u0151-test\u00fclet P\u00e1ndy K\u00e1lm\u00e1n K\u00f3rh\u00e1z II. Belgy\u00f3gy\u00e1szat-Kardiol\u00f3gia Gyula Semmelweis u. 1. 5700"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","volume-title":"V\u00e1ls\u00e1g \u00e9s meg\u00fajul\u00e1s a m\u00e1sodik vil\u00e1gh\u00e1bor\u00fa ut\u00e1ni epidemiol\u00f3giai fejl\u0151d\u00e9sben Magyarorsz\u00e1gon","year":"2008"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/CIRCULATIONAHA.107.693879","volume":"119","year":"2009","journal-title":"Circulation"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1056\/NEJMsa035507","volume":"349","year":"2003","journal-title":"N. Engl. 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