{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:34:51Z","timestamp":1648762491139},"reference-count":18,"publisher":"Akademiai Kiado Zrt.","issue":"50","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12,1]]},"abstract":"<jats:p>A k\u00f6penysejtes lymphoma egyes\u00edti az indolens \u00e9s az agressz\u00edv lymphom\u00e1k rossz tulajdons\u00e1gait, azaz az agressz\u00edv lymphom\u00e1khoz hasonl\u00f3an gyors lefoly\u00e1s\u00fa \u00e9s progressz\u00edv, \u00e9s az indolens lymphom\u00e1khoz hasonl\u00f3an kemoter\u00e1pi\u00e1val, illetve immunokemoter\u00e1pi\u00e1val nem gy\u00f3gy\u00edthat\u00f3. Az elm\u00falt \u00e9vekben sz\u00e1mos olyan el\u0151rel\u00e9p\u00e9s t\u00f6rt\u00e9nt, amely nagyban jav\u00edtja a k\u00f6penysejtes lymphom\u00e1s betegek \u00e9letkil\u00e1t\u00e1sait. Az intenzifik\u00e1lt immunokemoter\u00e1pi\u00e1ra j\u00f3l v\u00e1laszol\u00f3 betegek els\u0151 komplett remisszi\u00f3j\u00e1ban konszolid\u00e1ci\u00f3s kezel\u00e9st kell v\u00e9gezni. A konszolid\u00e1ci\u00f3: rituximab \u00e9s citozin-arabinosidal intenzifik\u00e1lt kezel\u00e9st k\u00f6vet\u0151en a lehet\u0151leg sug\u00e1rter\u00e1pi\u00e1t is alkalmaz\u00f3 kondicion\u00e1l\u00f3 kezel\u00e9s \u00e9s autol\u00f3g transzplant\u00e1ci\u00f3, amely a v\u00e1rhat\u00f3 \u00e1tlagos t\u00fal\u00e9l\u00e9st minden kor\u00e1bbi adathoz k\u00e9pest l\u00e9nyegesen meghosszabb\u00edtja (\u00e1tlag 2,5\u20133 \u00e9v helyett val\u00f3sz\u00edn\u0171leg 7\u201310 \u00e9v k\u00f6z\u00f6tt). A visszaes\u0151 betegek kezel\u00e9s\u00e9re pedig sz\u00e1mos \u00faj lehet\u0151s\u00e9g k\u00edn\u00e1lkozik, amelyek k\u00f6z\u00fcl az egyik legfontosabbat az Egyes\u00fclt \u00c1llamokban m\u00e1r erre a betegs\u00e9gre is t\u00f6rzsk\u00f6nyvezt\u00e9k. Az \u00faj ter\u00e1pi\u00e1s lehet\u0151s\u00e9gek \u00e1ttekint\u00e9s\u00e9vel foglalkozik a k\u00f6zlem\u00e9ny.<\/jats:p>","DOI":"10.1556\/oh.2009.28763","type":"journal-article","created":{"date-parts":[[2009,12,2]],"date-time":"2009-12-02T06:15:59Z","timestamp":1259734559000},"page":"2253-2257","source":"Crossref","is-referenced-by-count":0,"title":["Therapy of mantle cell lymphoma"],"prefix":"10.1556","volume":"150","author":[{"given":"Mikl\u00f3s","family":"Udvardy","sequence":"first","affiliation":[{"name":"1 Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum II. 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