{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:59:51Z","timestamp":1760061591246},"reference-count":34,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:p>Az elektrokemoter\u00e1pia daganatok b\u0151r\u00e1tt\u00e9teinek palliat\u00edv kezel\u00e9s\u00e9re alkalmas elj\u00e1r\u00e1s, amelynek sor\u00e1n nagy energi\u00e1j\u00fa elektromos impulzusok hat\u00e1s\u00e1ra a sejtek membr\u00e1nja \u00e1tereszt\u0151v\u00e9 v\u00e1lik olyan anyagok, \u00edgy kemoterapeutikumok sz\u00e1m\u00e1ra, amelyek egy\u00e9bk\u00e9nt nem vagy csak kism\u00e9rt\u00e9kben ker\u00fcln\u00e9nek a sejt belsej\u00e9be, ez\u00e1ltal megn\u00f6velve azok citotoxikus hat\u00e1s\u00e1t. \n <jats:italic>M\u00f3dszer:<\/jats:italic>\n Klinik\u00e1nkon 7, el\u0151rehaladott melanom\u00e1ban szenved\u0151 beteg 81 b\u0151r\u00e1tt\u00e9t\u00e9nek elektrokemoter\u00e1pi\u00e1s kezel\u00e9s\u00e9t v\u00e9gezt\u00fck el. A beavatkoz\u00e1sokat altat\u00e1sban, intrav\u00e9n\u00e1s bleomycin ad\u00e1s\u00e1val v\u00e9gezt\u00fck. Az \u00e1tlagos k\u00f6vet\u00e9si id\u0151 218 nap volt. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n A kezel\u00e9s hat\u00e1s\u00e1ra 25%-ban \u00e9szlelt\u00fcnk teljes, m\u00edg 43%-ban r\u00e9szleges remisszi\u00f3t. A kezelt metaszt\u00e1zisok 26%-\u00e1n\u00e1l nem t\u00f6rt\u00e9nt v\u00e1ltoz\u00e1s, m\u00edg 6%-ban a tumor n\u00f6vekedett. \n <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>\n Eredm\u00e9nyeink al\u00e1t\u00e1masztj\u00e1k azokat az irodalmi adatokat, amelyek szerint az elektrokemoter\u00e1pia egyszer\u0171en kivitelezhet\u0151, hat\u00e1sos m\u00f3dszer a melanoma t\u00f6bbsz\u00f6r\u00f6s b\u0151r\u00e1tt\u00e9teinek palliat\u00edv kezel\u00e9s\u00e9re. Az \u00faj elj\u00e1r\u00e1s kev\u00e9s mell\u00e9khat\u00e1ssal j\u00e1r, \u00e9s jav\u00edtja a betegek \u00e9letmin\u0151s\u00e9g\u00e9t.<\/jats:p>","DOI":"10.1556\/oh.2010.28781","type":"journal-article","created":{"date-parts":[[2010,1,10]],"date-time":"2010-01-10T02:01:35Z","timestamp":1263088895000},"page":"99-101","source":"Crossref","is-referenced-by-count":3,"title":["Electrochemotherapy of melanoma cutaneous metastases"],"prefix":"10.1556","volume":"151","author":[{"given":"Erika","family":"Kis","sequence":"first","affiliation":[{"name":"1 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged Kor\u00e1nyi fasor 6. 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Szegesdi","sequence":"additional","affiliation":[{"name":"2 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriette","family":"\u00d3csai","sequence":"additional","affiliation":[{"name":"1 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged Kor\u00e1nyi fasor 6. 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolland","family":"Gyulai","sequence":"additional","affiliation":[{"name":"1 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged Kor\u00e1nyi fasor 6. 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Kem\u00e9ny","sequence":"additional","affiliation":[{"name":"1 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged Kor\u00e1nyi fasor 6. 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Ol\u00e1h","sequence":"additional","affiliation":[{"name":"1 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged Kor\u00e1nyi fasor 6. 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0302-4598(00)00112-4","volume":"53","year":"2001","journal-title":"Bioelectrochemistry"},{"key":"atypb2","first-page":"45","volume":"4","year":"2006","journal-title":"Eur. 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