{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T20:31:07Z","timestamp":1769200267444,"version":"3.49.0"},"reference-count":22,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:p>A pyoderma gangraenosum a legismertebb IBD-vel asszoci\u00e1lt b\u0151rbetegs\u00e9g, leggyakrabban az IBD akt\u00edv f\u00e1zis\u00e1ban alakul ki. A visilizumab (Nuvion, PDL Bio Pharma, Amerikai Egyes\u00fclt \u00c1llamok) egy IgG2 t\u00edpus\u00fa monoklon\u00e1lis antitest, amely a T-lymphocyt\u00e1k felsz\u00edni CD3 receptor\u00e1nak epszilon-l\u00e1nc\u00e1hoz k\u00f6t\u0151dik, cs\u00f6kkenti a perif\u00e9ri\u00e1s v\u00e9rben l\u00e9v\u0151 nyugv\u00f3 T-sejteken a CXCR-3-medi\u00e1lt kemotaxist, valamint az aktiv\u00e1lt T-sejtek gyors apopt\u00f3zis\u00e1t id\u00e9zi el\u0151. \n <jats:italic>Esetismertet\u00e9s:<\/jats:italic>\n a 40 \u00e9ves f\u00e9rfi beteget az ut\u00f3bbi k\u00f6zel 20 \u00e9vben t\u00f6bb mint 30 alkalommal kezelt\u00e9k b\u0151rgy\u00f3gy\u00e1szaton ekzem\u00e1nak, illetve mycosisnak v\u00e9lt als\u00f3 v\u00e9gtagi b\u0151relv\u00e1ltoz\u00e1sok miatt. 1996 \u00f3ta ismert colitis ulceros\u00e1ja. Or\u00e1lis vagy sziszt\u00e9m\u00e1s szteroidkezel\u00e9sben 1997 \u00f3ta r\u00e9szes\u00fcl, amelynek az \u00e9vek sor\u00e1n sz\u00e1mos sz\u00f6v\u0151dm\u00e9nye alakult ki. A pyoderma gangraenosum diagn\u00f3zis\u00e1t 2005-ben \u00e1ll\u00edtott\u00e1k fel. 2006-ban a beteg egy gy\u00f3gyszervizsg\u00e1latban vett r\u00e9szt, amelynek sor\u00e1n k\u00e9t alkalommal 375 mcg visilizumabot kapott (5 mcg\/ttkg) intrav\u00e9n\u00e1san. Hat h\u00f3nappal a kezel\u00e9s ut\u00e1n a b\u0151relv\u00e1ltoz\u00e1sok csaknem teljesen beh\u00e1mosodtak. Pyoderm\u00e1s b\u0151rt\u00fcnetek az\u00f3ta sem jelentkeztek. \n <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n az eset alapj\u00e1n felmer\u00fcl, hogy a pyoderma gangraenosum etiol\u00f3gi\u00e1j\u00e1ban k\u00f3ros T-sejt-v\u00e1lasz j\u00e1tszhat szerepet. S\u00falyos colitis ulcerosa kezel\u00e9s\u00e9ben a visilizumab nem v\u00e1ltotta be a hozz\u00e1 f\u0171z\u00f6tt rem\u00e9nyeket, azonban a pyoderma gangraenosum eset\u00e9ben egy \u00faj ter\u00e1pi\u00e1s lehet\u0151s\u00e9get jelenthet.<\/jats:p>","DOI":"10.1556\/oh.2010.28786","type":"journal-article","created":{"date-parts":[[2010,4,9]],"date-time":"2010-04-09T01:56:24Z","timestamp":1270778184000},"page":"144-147","source":"Crossref","is-referenced-by-count":9,"title":["Pyoderma gangrenosum treated successfully with visilizumab in patients with ulcerative colitis"],"prefix":"10.1556","volume":"151","author":[{"given":"Magdolna","family":"L\u0151rincz","sequence":"first","affiliation":[{"name":"1 J\u00e1vorszky \u00d6d\u00f6n K\u00f3rh\u00e1z Gasztroenterol\u00f3giai Oszt\u00e1ly V\u00e1c Argenti D\u00f6me t\u00e9r 1\u20133. 2600"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Kleszky","sequence":"additional","affiliation":[{"name":"2 J\u00e1vorszky \u00d6d\u00f6n K\u00f3rh\u00e1z B\u0151r- \u00e9s Nemibeteg-gondoz\u00f3 V\u00e1c"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Szal\u00f3ki Jr.","sequence":"additional","affiliation":[{"name":"3 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar V. \u00e9vfolyam Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Szal\u00f3ki","sequence":"additional","affiliation":[{"name":"1 J\u00e1vorszky \u00d6d\u00f6n K\u00f3rh\u00e1z Gasztroenterol\u00f3giai Oszt\u00e1ly V\u00e1c Argenti D\u00f6me t\u00e9r 1\u20133. 2600"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","first-page":"1391","volume":"141","year":"2000","journal-title":"Orv. 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