{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:13:25Z","timestamp":1785464005188,"version":"3.56.0"},"reference-count":37,"publisher":"Akademiai Kiado Zrt.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"abstract":"<jats:p>Az adjuv\u00e1ns gy\u00f3gyszeres ter\u00e1pia sikeres alkalmaz\u00e1s\u00e1val els\u0151sorban a t\u00e1voli metaszt\u00e1zisok kialakul\u00e1s\u00e1nak es\u00e9lye cs\u00f6kkenthet\u0151, a diagn\u00f3zis idej\u00e9n fenn\u00e1ll\u00f3 mikrometaszt\u00e1zisok megsz\u00fcntet\u00e9se r\u00e9v\u00e9n. \n <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>\n A korai eml\u0151r\u00e1k posztoperat\u00edv sziszt\u00e9m\u00e1s gy\u00f3gyszeres kezel\u00e9si lehet\u0151s\u00e9geinek \u00e1ttekint\u00e9se. \n <jats:italic>M\u00f3dszer:<\/jats:italic>\n A szerz\u0151 az irodalmi adatok \u00e9s saj\u00e1t tapasztalata alapj\u00e1n \u00f6sszefoglalja a korai eml\u0151r\u00e1k m\u0171t\u00e9ti megold\u00e1s\u00e1t k\u00f6vet\u0151 sziszt\u00e9m\u00e1s ter\u00e1pia legfontosabb szempontjait. \n <jats:italic>Eredm\u00e9nyek:<\/jats:italic>\n Az adjuv\u00e1ns kezel\u00e9s sor\u00e1n citotoxikus kezel\u00e9s, hormonter\u00e1pia \u00e9s HER2 receptort c\u00e9lz\u00f3 biol\u00f3giai ter\u00e1pia, illetve ezek kombin\u00e1ci\u00f3ja ker\u00fcl alkalmaz\u00e1sra. Az endokrin kezel\u00e9sben fontos szerepe van a tamoxifenter\u00e1pi\u00e1nak, amelyet mind a premenopauz\u00e1lis, mind a posztmenopauz\u00e1lis eml\u0151r\u00e1k kezel\u00e9s\u00e9ben alkalmaznak. Premenopauz\u00e1ban az elfogadott standard hormonter\u00e1pi\u00e1t az LH-RH anal\u00f3ggal v\u00e9gzett petef\u00e9szek-szuppresszi\u00f3 \u00e9s\/vagy tamoxifenkezel\u00e9s k\u00e9pezi. Posztmenopauz\u00e1ban az adjuv\u00e1ns endokrin kezel\u00e9sben ma m\u00e1r a harmadik gener\u00e1ci\u00f3s aromat\u00e1zg\u00e1tl\u00f3k is szerepet kapnak, b\u00e1r m\u00e9g nem tiszt\u00e1zott, hogy az inici\u00e1lis, a szekvenci\u00e1lis vagy a meghosszabb\u00edtott ter\u00e1pia jelenti-e az optim\u00e1lis strat\u00e9gi\u00e1t. Az adjuv\u00e1ns polikemoter\u00e1pia els\u0151sorban a nyirokcsom\u00f3\u00e1tt\u00e9tes esetekben ker\u00fcl alkalmaz\u00e1sra, emellett a magas rizik\u00f3j\u00fa nyirokcsom\u00f3-negat\u00edv betegek posztoperat\u00edv kezel\u00e9s\u00e9ben is egyre gyakrabban alkalmazz\u00e1k. Az alkil\u00e1l\u00f3k \u00e9s antraciklinek mellett a tax\u00e1nok (docetaxel \u00e9s paclitaxel) bevezet\u00e9se komoly el\u0151rehalad\u00e1st hozott az adjuv\u00e1ns kemoter\u00e1pi\u00e1ban. Ma m\u00e1r biol\u00f3giai c\u00e9lzott ter\u00e1pia, a trastuzumabter\u00e1pia is fontos r\u00e9sz\u00e9t k\u00e9pezi a m\u0171t\u00e9t ut\u00e1ni kezel\u00e9snek, amelynek id\u0151tartama a jelenlegi szakmai aj\u00e1nl\u00e1sok alapj\u00e1n egy \u00e9v. \n <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>\n Az elm\u00falt \u00e9vekben bevezetett tax\u00e1ntartalm\u00fa kemoter\u00e1pi\u00e1k, a posztmenopauz\u00e1lis eml\u0151r\u00e1kban alkalmazott harmadik gener\u00e1ci\u00f3s aromat\u00e1zg\u00e1tl\u00f3k \u00e9s az adjuv\u00e1ns trastuzumab alkalmaz\u00e1sa mind l\u00e9nyegesen hozz\u00e1j\u00e1rulnak a korai eml\u0151r\u00e1kban szenved\u0151 betegek gy\u00f3gyul\u00e1si es\u00e9lyeihez.<\/jats:p>","DOI":"10.1556\/oh.2010.28824","type":"journal-article","created":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T02:04:40Z","timestamp":1266372280000},"page":"344-353","source":"Crossref","is-referenced-by-count":3,"title":["Adjuvant systemic therapy of early stage breast cancer"],"prefix":"10.1556","volume":"151","author":[{"given":"Katalin","family":"Bo\u00e9r","sequence":"first","affiliation":[{"name":"1 F\u0151v\u00e1rosi \u00d6nkorm\u00e1nyzat Szent J\u00e1nos K\u00f3rh\u00e1za \u00e9s \u00c9szak-budai Egyes\u00edtett K\u00f3rh\u00e1zai Budapest Szent Margit K\u00f3rh\u00e1z Telephely, Onkol\u00f3giai Oszt\u00e1ly Budapest B\u00e9csi \u00fat 132. 1032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3322\/CA.2007.0010","volume":"58","year":"2008","journal-title":"CA. 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