{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:43:22Z","timestamp":1762375402723},"reference-count":48,"publisher":"Akademiai Kiado Zrt.","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:p>Az emberi 7-es herpeszv\u00edrus 1990 \u00f3ta ismert, k\u00f6zeli rokons\u00e1gban \u00e1ll a 6-os herpeszv\u00edrussal, annak B v\u00e1ltozat\u00e1val. Csak emberi sejtekben szaporodik, receptora a CD4 molekula. A fert\u0151z\u00f6tt sejtek egy r\u00e9sz\u00e9ben \u00e9lethossziglan lappang, gyakran reaktiv\u00e1l\u00f3dik \u00e9s a ny\u00e1lban t\u00fcnetmentesen \u00fcr\u00fcl. Gyermekek egy r\u00e9sze 3\u20134 \u00e9ves kor\u00e1ra t\u00fcnetmentesen fert\u0151z\u0151dik, de minden \u00e9letkorban tal\u00e1lhat\u00f3k szeronegat\u00edv egy\u00e9nek, akik fog\u00e9konyak a fert\u0151z\u00e9s ir\u00e1nt. Gyermekekben ritk\u00e1n exanthema subitum, m\u00fal\u00f3 l\u00e1zas-g\u00f6rcs\u00f6s \u00e1llapotok, fiatal feln\u0151ttekben r\u00f3zsah\u00e1ml\u00e1s, immunszuppressz\u00e1lt egy\u00e9nekben a reaktiv\u00e1l\u00f3dott 6-os B herpeszv\u00edrussal \u00e9s cytomegalovirussal egyetemben hal\u00e1los sz\u00f6v\u0151dm\u00e9nyek alakulhatnak ki. Egy\u00e9b v\u00edrusokat is aktiv\u00e1lhat m\u00e1s k\u00f3rk\u00e9pekben. A v\u00edrus patogenezis\u00e9ben a legfontosabb, hogy megv\u00e1ltozik a fert\u0151z\u00f6tt lymphocyt\u00e1kb\u00f3l ki\u00e1raml\u00f3 citokinek \u00e9s n\u00f6veked\u00e9si faktorok egyens\u00falya, amely l\u00e1ncreakci\u00f3k\u00e9nt hat az immunrendszer \u00e9s egy\u00e9b szervek sejtjeire. A v\u00edrusellenes antitestek kimutat\u00e1sa kereskedelmi forgalomban kaphat\u00f3 k\u00e9szletekkel (immunfluoreszcencia, ELISA, immunoblot), a nukleinsav kimutat\u00e1sa f\u00e9szkes polimer\u00e1z l\u00e1ncreakci\u00f3val lehets\u00e9ges. A fert\u0151z\u00e9s k\u00f6vetkezt\u00e9ben kialakult betegs\u00e9gek legt\u00f6bbje nem ig\u00e9nyel kezel\u00e9st, de s\u00falyos sz\u00f6v\u0151dm\u00e9nyek eset\u00e9n ganciclovir \u00e9s sz\u00e1rmaz\u00e9kai, valamint foscarnet \u00e9s cidofovir alkalmazhat\u00f3.<\/jats:p>","DOI":"10.1556\/oh.2010.28856","type":"journal-article","created":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T01:11:25Z","timestamp":1269997885000},"page":"645-651","source":"Crossref","is-referenced-by-count":5,"title":["Human herpesvirus 7"],"prefix":"10.1556","volume":"151","author":[{"given":"J\u00f3zsef","family":"Ongr\u00e1di","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar K\u00f6zeg\u00e9szs\u00e9gtani Int\u00e9zet Budapest Nagyv\u00e1rad t\u00e9r 4. 1089"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria","family":"K\u00f6vesdi","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar K\u00f6zeg\u00e9szs\u00e9gtani Int\u00e9zet Budapest Nagyv\u00e1rad t\u00e9r 4. 1089"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enik\u0151","family":"Kov\u00e1ts","sequence":"additional","affiliation":[{"name":"2 Einstein Pediatrics Jenkintown PA Amerikai Egyes\u00fclt \u00c1llamok"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.87.2.748","volume":"87","year":"1990","journal-title":"Proc. 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