{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:14:57Z","timestamp":1760577297204},"reference-count":50,"publisher":"Akademiai Kiado Zrt.","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,1]]},"abstract":"<jats:p>Az imikimod, az imidazol-kinolin-aminok csal\u00e1dj\u00e1ba tartoz\u00f3, kis, szintetikus, nukleotidszer\u0171 molekula. Ismert immunv\u00e1lasz-m\u00f3dos\u00edt\u00f3, v\u00edrusellenes \u00e9s tumorellenes hat\u00e1sa, amelyet a Toll-like receptorok (TLR7 \u00e9s TLR8) k\u00f6zvet\u00edtenek. Az imikimod f\u0151k\u00e9nt a TLR7-et kifejez\u0151 plazmacitoid dendritikus sejteket \u00e9s a Langerhans-sejteket c\u00e9lozza meg, \u00e9s csak m\u00e1sodlagosan vesz r\u00e9szt egy\u00e9b gyullad\u00e1sos sejtek aktiv\u00e1l\u00e1s\u00e1ban. A TLR7 stimul\u00e1ci\u00f3jakor induk\u00e1l\u00f3d\u00f3 jel\u00e1tviteli mechanizmusok mind a velesz\u00fcletett, mind a szerzett immunrendszert aktiv\u00e1lj\u00e1k, k\u00fcl\u00f6n\u00f6s tekintettel a sejt \u00e1ltal k\u00f6zvet\u00edtett immunreakci\u00f3kra. Az 5%-os imikimodkr\u00e9m (Aldara, MEDA Pharma) lok\u00e1lis alkalmaz\u00e1sa hat\u00e9konynak bizonyult az aktinikus keratosisok, a superficialis basaliom\u00e1k \u00e9s a k\u00fcls\u0151 nemi szerveken \u00e9s perianalisan elhelyezked\u0151 condylom\u00e1k kezel\u00e9s\u00e9ben. Az imikimod k\u00fcl\u00f6n\u00f6sen alkalmas kiterjedt, l\u00e1tsz\u00f3lag t\u00fcnetmentes, de daganatsejteket tartalmaz\u00f3 mez\u0151k (\u201efield cancerization\u201d) kezel\u00e9s\u00e9re. A beteg \u00e1ltal alkalmazott otthoni kezel\u00e9s kiv\u00e1l\u00f3 kozmetikai eredm\u00e9nyt ad. Irodalmi adatok utalnak tov\u00e1bb\u00e1 az imikimod hat\u00e9konys\u00e1g\u00e1ra nodularis basalioma \u00e9s egy\u00e9b, nem melanomat\u00edpus\u00fa b\u0151rdaganat kezel\u00e9s\u00e9ben. Az imikimod lok\u00e1lis alkalmaz\u00e1sa j\u00f3l toler\u00e1lhat\u00f3, a kr\u00e9m az alkalmaz\u00e1s hely\u00e9n enyhe vagy k\u00f6zepesen s\u00falyos gyullad\u00e1sos reakci\u00f3t okozhat. Ez a dolgozat \u00e1tfog\u00f3 k\u00e9pet ad az imikimod alkalmaz\u00e1s\u00e1val kapcsolatos eddigi tapasztalatokr\u00f3l \u00e9s a potenci\u00e1lis j\u00f6v\u0151beli felhaszn\u00e1l\u00e1si lehet\u0151s\u00e9gekr\u0151l.<\/jats:p>","DOI":"10.1556\/oh.2010.28866","type":"journal-article","created":{"date-parts":[[2010,4,29]],"date-time":"2010-04-29T02:12:46Z","timestamp":1272507166000},"page":"774-783","source":"Crossref","is-referenced-by-count":6,"title":["New perspective in immunotherapy: local imiquimod treatment"],"prefix":"10.1556","volume":"151","author":[{"given":"Lajos","family":"Kem\u00e9ny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikoletta","family":"Nagy","sequence":"additional","affiliation":[{"name":"1 Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika Szeged Kor\u00e1nyi fasor 6. 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1067\/mjd.2002.125579","volume":"47","year":"2002","journal-title":"J. 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