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Az IL-17A epithel- \u00e9s endothelsejteken, fibroblastokon \u00e9s a leukocyt\u00e1kon tal\u00e1lhat\u00f3 sejtfelsz\u00edni receptor\u00e1n kereszt\u00fcl tov\u00e1bbi gyullad\u00e1sos medi\u00e1torok felszabad\u00edt\u00e1s\u00e1val \u00e9s neutrophil granulocyt\u00e1k aktiv\u00e1l\u00e1s\u00e1val vesz r\u00e9szt az immunv\u00e1lasz szab\u00e1lyoz\u00e1s\u00e1ban. Az immunregul\u00e1ci\u00f3 \u00e9rz\u00e9keny egyens\u00faly\u00e1nak megboml\u00e1sa gyullad\u00e1sos \u00e9s autoimmun betegs\u00e9gekhez vezet. A Th17 sejtek \u00e9s az \u00e1ltaluk termelt citokinek kiemelt szerep\u00e9t sz\u00e1mos hum\u00e1n autoimmun k\u00f3rk\u00e9pben, k\u00f6zt\u00fck a rheumatoid arthritisben is igazolt\u00e1k. 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Immunol."},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.20070663","volume":"204","year":"2007","journal-title":"J. Exp. Med."},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ni1467","volume":"8","year":"2007","journal-title":"Nat. Immunol."},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","volume":"6","year":"2005","journal-title":"Nat. Immunol."},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/ni.1610","volume":"9","year":"2008","journal-title":"Nat. Immunol."},{"key":"atypb7","first-page":"650","volume":"9","year":"2008","journal-title":"Nat. Immunol."},{"key":"atypb8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","volume":"441","year":"2006","journal-title":"Nature"},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/rheumatology\/kep028","volume":"48","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"26R","DOI":"10.1203\/PDR.0b013e31819e76c7","volume":"65","year":"2009","journal-title":"Pediatr. Res."},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"9358","DOI":"10.1074\/jbc.C600321200","volume":"282","year":"2007","journal-title":"J. Biol. Chem."},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","volume":"126","year":"2006","journal-title":"Cell"},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature05970","volume":"448","year":"2007","journal-title":"Nature"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature05969","volume":"448","year":"2007","journal-title":"Nature"},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","volume":"201","year":"2005","journal-title":"J. Exp. Med."},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"13447","DOI":"10.1074\/jbc.M700499200","volume":"282","year":"2007","journal-title":"J. Biol. Chem."},{"key":"atypb17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/cr.2007.35","volume":"17","year":"2007","journal-title":"Cell Res."},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4049\/jimmunol.175.1.404","volume":"175","year":"2005","journal-title":"J. Immunol."},{"key":"atypb19","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.4049\/jimmunol.178.7.4466","volume":"178","year":"2007","journal-title":"J. Immunol."},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.4049\/jimmunol.170.4.2106","volume":"170","year":"2003","journal-title":"J. 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Immunol."},{"key":"atypb27","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.4049\/jimmunol.179.8.5462","volume":"179","year":"2007","journal-title":"J. Immunol."},{"key":"atypb28","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/1074-7613(95)90070-5","volume":"3","year":"1995","journal-title":"Immunity"},{"key":"atypb29","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1189\/jlb.0904490","volume":"77","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"atypb30","doi-asserted-by":"crossref","first-page":"6504","DOI":"10.4049\/jimmunol.179.10.6504","volume":"179","year":"2007","journal-title":"J. Immunol."},{"key":"atypb31","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1186\/ar1470","volume":"7","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"atypb32","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","volume":"423","year":"2003","journal-title":"Nature"},{"key":"atypb33","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1097\/01.rhu.0000166673.34461.33","volume":"11","year":"2005","journal-title":"J. Clin. Rheumatol."},{"key":"atypb34","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1002\/art.24127","volume":"58","year":"2008","journal-title":"Arthritis Rheum."},{"key":"atypb35","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.4049\/jimmunol.171.11.6173","volume":"171","year":"2003","journal-title":"J. Immunol."},{"key":"atypb36","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/03009740701286813","volume":"36","year":"2007","journal-title":"Scand. J. 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Chem."},{"key":"atypb42","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/art.21211","volume":"52","year":"2005","journal-title":"Arthritis Rheum."},{"key":"atypb43","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1006\/bbrc.2000.3379","volume":"275","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"atypb44","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.coi.2006.09.008","volume":"18","year":"2006","journal-title":"Curr. Opin. Immunol."},{"key":"atypb45","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1172\/JCI7739","volume":"105","year":"2000","journal-title":"J. Clin. Invest."},{"key":"atypb46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1084\/jem.20061531","volume":"204","year":"2007","journal-title":"J. Exp. 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