{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:15:50Z","timestamp":1777526150705,"version":"3.51.4"},"reference-count":40,"publisher":"Akademiai Kiado Zrt.","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:p>A hepatocellularis carcinoma (HCC) vil\u00e1gviszonylatban a hal\u00e1lhoz vezet\u0151 rosszindulat\u00fa daganatos betegs\u00e9gek k\u00f6z\u00f6tt a harmadik leggyakoribb megbeteged\u00e9s. Az esetek d\u00f6nt\u0151 r\u00e9sz\u00e9ben (80\u201390%) m\u00e1jcirrhosis talaj\u00e1n alakul ki. A cirrhosis f\u0151 oka a kr\u00f3nikus B- \u00e9s C-v\u00edrus-fert\u0151z\u00e9s, valamint a tart\u00f3s alkoholfogyaszt\u00e1s. Alkoholos eredet\u0171 m\u00e1jcirrhosisos betegekben a hepatocellularis carcinoma el\u0151fordul\u00e1si gyakoris\u00e1ga 3\u201315% k\u00f6r\u00fcl van. Egy\u00e9b kiv\u00e1lt\u00f3 okok lehetnek tov\u00e1bb\u00e1 a nem alkoholos steatohepatitis (NASH), az obesitas, diabetes mellitus, autoimmun hepatitis, m\u00e1jon bel\u00fcli epe\u00fatgyullad\u00e1s (primer biliaris cirrhosis, primer sclerotiz\u00e1l\u00f3 cholangitis), r\u00e9z- \u00e9s vasanyagcsere-betegs\u00e9gek (Wilson-k\u00f3r, haemochromatosis), velesz\u00fcletett alfa-1-antitripszin-hi\u00e1ny. Tov\u00e1bbi k\u00f3roki t\u00e9nyez\u0151k\u00e9nt a doh\u00e1nyz\u00e1s \u00e9s k\u00fcl\u00f6nb\u00f6z\u0151 k\u00e9miai anyagok j\u00f6hetnek sz\u00e1m\u00edt\u00e1sba. M\u00edg kor\u00e1bban a HCC-s betegek csak szupport\u00edv, palliat\u00edv kezel\u00e9sben r\u00e9szes\u00fclhettek, manaps\u00e1g a ter\u00e1pia sz\u00e9les sk\u00e1l\u00e1ja ismert. A seb\u00e9szeti beavatkoz\u00e1sok (reszekci\u00f3, m\u00e1jtranszplant\u00e1ci\u00f3) mellett az invaz\u00edv radioter\u00e1pia is sz\u00e9les k\u00f6rben elterjedt. \u00dajabban bizony\u00edtott\u00e1k a monoklon\u00e1lis antitestekkel v\u00e9gzett c\u00e9lzott ter\u00e1pia hat\u00e1soss\u00e1g\u00e1t, valamint a kis molekul\u00e1j\u00fa kin\u00e1zinhibitorok eredm\u00e9nyess\u00e9g\u00e9t. 2007-ben ker\u00fclt forgalomba a t\u00f6bb ter\u00fcleten hat\u00f3 kin\u00e1zinhibitor, a sorafenib, amely jelent\u0151s m\u00e9rt\u00e9kben n\u00f6velte az el\u0151rehaladott HCC-s betegek t\u00fal\u00e9l\u00e9si idej\u00e9t.<\/jats:p>","DOI":"10.1556\/oh.2010.28900","type":"journal-article","created":{"date-parts":[[2010,5,23]],"date-time":"2010-05-23T01:01:49Z","timestamp":1274576509000},"page":"933-940","source":"Crossref","is-referenced-by-count":8,"title":["Hepatocellular carcinoma: occurrence, risk factors, biomarkers"],"prefix":"10.1556","volume":"151","author":[{"given":"J\u00e1nos","family":"Feh\u00e9r","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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