{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T21:09:39Z","timestamp":1694639379862},"reference-count":49,"publisher":"Akademiai Kiado Zrt.","issue":"26","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:p>A de novo diabetes mellitus a m\u00e1j\u00e1t\u00fcltet\u00e9s gyakori sz\u00f6v\u0151dm\u00e9nye.<jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>A de novo diabetes gyakoris\u00e1g\u00e1t, jelent\u0151s\u00e9g\u00e9t \u00e9s a kock\u00e1zati t\u00e9nyez\u0151k szerep\u00e9t vizsg\u00e1ltuk.<jats:italic>M\u00f3dszer:<\/jats:italic>1995 \u00e9s 2009 k\u00f6z\u00f6tt 310 m\u00e1j\u00e1t\u00fcltetett beteg adatait dolgoztuk fel retrospekt\u00edv m\u00f3dszerrel. De novo diabetest \u00e1llap\u00edtottunk meg, ha az \u00e9homi v\u00e9rcukor a 3. posztoperat\u00edv h\u00f3napon t\u00fal ism\u00e9telten &gt;6,8 mmol\/l volt, \u00e9s\/vagy a m\u00e1j\u00e1t\u00fcltet\u00e9s ut\u00e1n tart\u00f3s, a 3. posztoperat\u00edv h\u00f3napot meghalad\u00f3an is fenntartott antidiabetikus ter\u00e1pia indult.<jats:italic>Eredm\u00e9nyek:<\/jats:italic>De novo diabetes a betegek 20%-\u00e1n\u00e1l (63 beteg) alakult ki. A de novo \u00e9s a kontrollcsoport k\u00f6z\u00f6tt az al\u00e1bbiakban tal\u00e1ltunk k\u00fcl\u00f6nbs\u00e9get. Donor-testt\u00f6megindex (24\u00b13 vs. 22,4\u00b13,6 kg\/m<jats:sup>2<\/jats:sup>, p = 0,003), f\u00e9rfi nem (58% vs. 33%, p = 0,002). Recipiens\u00e9letkor (47,6\u00b17,2 vs. 38,3\u00b114,6 \u00e9v, p&lt;0,001), -testt\u00f6megindex (26,7\u00b13,8 vs. 23,3\u00b15,6 kg\/m<jats:sup>2<\/jats:sup>, p&lt;0,001), f\u00e9rfi nem (60% vs. 44%, p = 0,031). A de novo diabetesesek csoportj\u00e1ban a betegek 66%-\u00e1t HCV talaj\u00e1n kialakult cirrhosis miatt transzplant\u00e1lt\u00e1k, a kontrollcsoportban ez csak 23% volt (p&lt;0,001). Az 1, 3, 5 \u00e9s 8 \u00e9ves kumulat\u00edv betegt\u00fal\u00e9l\u00e9s a kontrollcsoportban 95%, 91%, 88% \u00e9s 88%, a de novo csoportban a megfelel\u0151 \u00e9rt\u00e9kek 87%, 79%, 79% \u00e9s 64% (p = 0,011). Az 1, 3, 5 \u00e9s 8 \u00e9ves kumulat\u00edv graftt\u00fal\u00e9l\u00e9s a kontrollcsoportban 92%, 87%, 86% \u00e9s 79%, a de novo csoportban a megfelel\u0151 \u00e9rt\u00e9kek 87%, 79%, 79%, 65% (p = NS). Azokn\u00e1l a betegekn\u00e9l, akikn\u00e9l a C-v\u00edrus korai (6 h\u00f3napon bel\u00fcli) ki\u00fajul\u00e1s\u00e1t \u00e9szlelt\u00fck, t\u00f6bbs\u00e9gben de novo diabetes is kialakult (74% vs. kontroll 26%, p = 0,03). A betegek 53%-\u00e1ban \u00e9szlelt\u00fcnk t\u00edzszeres v\u00edrustiter-emelked\u00e9st a m\u0171t\u00e9t ut\u00e1ni 6 h\u00f3napon bel\u00fcl a preoperat\u00edv \u00e9rt\u00e9khez viszony\u00edtva diabetes kialakul\u00e1sa eset\u00e9n, a kontrolln\u00e1l ez 20% volt (p = 0,028). A de novo csoportban magasabb volt az \u00e1tlagos (Ishak-Knodell) fibrosis score az antivir\u00e1lis kezel\u00e9s megkezd\u00e9s\u00e9t k\u00f6vet\u0151en 1 \u00e9vvel (2,05\u00b11,53 vs. 1,00\u00b11,08, p = 0,039).<jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>M\u00e1j\u00e1t\u00fcltet\u00e9st k\u00f6vet\u0151 de novo diabetes kock\u00e1zati t\u00e9nyez\u0151i az id\u0151skor, elh\u00edz\u00e1s, f\u00e9rfi nem \u00e9s a C-v\u00edrus okozta cirrhosis. V\u00edruspozit\u00edv betegek k\u00f6r\u00e9ben a korai rekurrencia, s\u00falyosabb viraemia \u00e9s az antivir\u00e1lis kezel\u00e9s ellen\u00e9re kialakul\u00f3 s\u00falyosabb fibrosis \u00f6sszef\u00fcgg a de novo diabetes kialakul\u00e1s\u00e1val.<\/jats:p>","DOI":"10.1556\/oh.2010.28902","type":"journal-article","created":{"date-parts":[[2010,6,18]],"date-time":"2010-06-18T02:38:48Z","timestamp":1276828728000},"page":"1062-1071","source":"Crossref","is-referenced-by-count":5,"title":["New-onset diabetes mellitus after liver transplantation"],"prefix":"10.1556","volume":"151","author":[{"given":"Bal\u00e1zs","family":"Nemes","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Transzplant\u00e1ci\u00f3s \u00e9s Seb\u00e9szeti Klinika Budapest Baross u. 23. 1082"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanni","family":"Gelley","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Transzplant\u00e1ci\u00f3s \u00e9s Seb\u00e9szeti Klinika Budapest Baross u. 23. 1082"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gergely","family":"Z\u00e1dori","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Transzplant\u00e1ci\u00f3s \u00e9s Seb\u00e9szeti Klinika Budapest Baross u. 23. 1082"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"F\u00f6ldes","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Transzplant\u00e1ci\u00f3s \u00e9s Seb\u00e9szeti Klinika Budapest Baross u. 23. 1082"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Firneisz","sequence":"additional","affiliation":[{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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