{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T21:23:03Z","timestamp":1694640183174},"reference-count":35,"publisher":"Akademiai Kiado Zrt.","issue":"37","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:p>A hepatocellularis carcinoma (HCC) gyakoris\u00e1ga vil\u00e1gszerte n\u00f6vekszik. Haz\u00e1nkban \u00e9vente k\u00f6r\u00fclbel\u00fcl 600 \u00faj esettel lehetne sz\u00e1molni, de a rendelkez\u00e9sre \u00e1ll\u00f3 adatok szerint enn\u00e9l sokkal kevesebb jut a hepatol\u00f3giai gondoz\u00e1s rendszer\u00e9be. A sorafenib megjelen\u00e9se \u00e9s az ablat\u00edv kezel\u00e9sek terjed\u00e9se mellett a legjobb eredm\u00e9nyek a seb\u00e9szi m\u00f3dszerekt\u0151l v\u00e1rhat\u00f3k. Az orthotopicus m\u00e1j\u00e1t\u00fcltet\u00e9s (OTLX) szelekt\u00e1lt korai HCC-esetekben igen b\u00edztat\u00f3 eredm\u00e9nyeket \u00edg\u00e9r ugyan, de a hazai transzplant\u00e1ci\u00f3s kapacit\u00e1s \u00e9s az \u00e9szlelt HCC-esetek st\u00e1diuma kiz\u00e1rja, hogy az OTLX legyen az egyed\u00fcli megold\u00e1s. A seb\u00e9szi reszekci\u00f3t a funkcion\u00e1lis m\u00e1jt\u00e9rfogat hat\u00e1rozza meg. A ballebeny-reszekci\u00f3t a betegek t\u00f6bbnyire j\u00f3l t\u0171rik. A jobb lebeny tumorai a portaf\u0151t\u00f6rzs okkl\u00fazi\u00f3ja ut\u00e1n \u2013 megfelel\u0151 bal oldali regener\u00e1ci\u00f3 eset\u00e9n \u2013 cirrhoticus m\u00e1jban is reszek\u00e1lhat\u00f3k. Az intraoperat\u00edv prekondicion\u00e1l\u00e1s jelent\u0151sen cs\u00f6kkenteni k\u00e9pes az ischaemi\u00e1s-reperf\u00fazi\u00f3s k\u00e1rosod\u00e1st jelz\u0151 faktorok sz\u00e9rumszintj\u00e9t \u00e9s a m\u0171t\u00e9ti kock\u00e1zatot. A Semmelweis Egyetem I. Seb\u00e9szeti Klinik\u00e1j\u00e1n 1996\u20132009 k\u00f6z\u00f6tt oper\u00e1lt 2167 m\u00e1jtumor k\u00f6z\u00f6tt 254 HCC fordult el\u0151. K\u00e9tsz\u00e1ztizenegy esetben t\u00f6rt\u00e9nt radik\u00e1lis m\u0171t\u00e9t, ez 82,7%-os reszekci\u00f3s r\u00e1t\u00e1nak felel meg. Vil\u00e1gszerte elterjed\u0151ben van a laparoszk\u00f3pos m\u00e1jreszekci\u00f3, amely kisebb m\u0171t\u00e9ti megterhel\u00e9st jelent, mint a nyitott m\u0171t\u00e9t, ez\u00e9rt cirrhoticus m\u00e1j eset\u00e9ben a javallat fokozottan \u00e9rv\u00e9nyes. Orv. Hetil., 2010, 37, 1483\u20131487.<\/jats:p>","DOI":"10.1556\/oh.2010.28905","type":"journal-article","created":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T02:56:10Z","timestamp":1283309770000},"page":"1483-1487","source":"Crossref","is-referenced-by-count":0,"title":["Surgical oncology of hepatocellular carcinoma (HCC)"],"prefix":"10.1556","volume":"151","author":[{"given":"P\u00e9ter","family":"Kupcsulik","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Seb\u00e9szeti Klinika Budapest \u00dcll\u0151i \u00fat 78. 1082"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1245\/s10434-007-9727-7","volume":"15","year":"2008","journal-title":"Ann. Surg. Oncology"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1200\/JCO.2005.01.3441","volume":"24","year":"2006","journal-title":"J. Clin. 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