{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:14:58Z","timestamp":1761765298892},"reference-count":34,"publisher":"Akademiai Kiado Zrt.","issue":"28","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,1]]},"abstract":"<jats:p>A kr\u00f3nikus v\u00edrushepatitisek jelentik ma a legismertebb okokat a hepatocellularis carcinoma (HCC) kialakul\u00e1s\u00e1ban. A kr\u00f3nikus B- \u00e9s C-v\u00edrus-hepatitis a m\u00e1jr\u00e1kok k\u00f6r\u00fclbel\u00fcl 40-50%-\u00e1t okozza. A nyugati t\u00edpus\u00fa t\u00e1rsadalmakban a HCC el\u0151fordul\u00e1sa folyamatosan n\u00f6vekv\u0151 tendenci\u00e1t mutat. Az alkohol sz\u00e1m\u00edt a k\u00f6rnyezeti t\u00e9nyez\u0151k k\u00f6z\u00fcl a legfontosabbnak, b\u00e1r az alkoholfogyaszt\u00e1s a legt\u00f6bb orsz\u00e1gban cs\u00f6kken. Ez al\u00e1h\u00fazza az egy\u00e9b k\u00f6rnyezeti t\u00e9nyez\u0151k fontoss\u00e1g\u00e1t is. Az elfogyasztott alkoholmennyis\u00e9ggel egyenes ar\u00e1nyban n\u00f6vekszik a cirrhosis \u00e9s a k\u00f6vetkezm\u00e9nyes HCC gyakoris\u00e1ga n\u0151kben \u00e9s f\u00e9rfiakban egyar\u00e1nt. A k\u00e9miai anyagok k\u00f6z\u00fcl a legismertebb a K\u00edn\u00e1ban \u00e9s Afrik\u00e1ban elterjedt aflatoxin, amely a gabonaf\u00e9l\u00e9ket szennyez\u0151 mycotoxin. Hasonl\u00f3 ter\u00fcleteken end\u00e9mi\u00e1s, mint a hepatitis B-v\u00edrus, egy\u00fctt szinergista hat\u00e1st fejtenek ki. A doh\u00e1nyz\u00e1s is egy\u00e9rtelm\u0171en bizony\u00edtott hepatocarcinogen hat\u00e1ssal rendelkezik. Ez is jelent\u0151sen fokoz\u00f3dik, ha alkoholfogyaszt\u00e1ssal vagy v\u00edrushepatitisszel t\u00e1rsul. T\u00e1rsadalmilag tal\u00e1n a legfontosabb az elh\u00edz\u00e1s, a k\u00f6vetkezm\u00e9nyes nem alkoholos zs\u00edrm\u00e1j, illetve steatohepatitis \u00e9s a 2-es t\u00edpus\u00fa cukorbetegs\u00e9g, amelyek prevalenci\u00e1ja egyre fokoz\u00f3dik. Feltehet\u0151en ezek \u00e1llnak a n\u00f6vekv\u0151 HCC-gyakoris\u00e1g h\u00e1tter\u00e9ben. Az inzulinrezisztencia \u00e9s az oxidat\u00edv stressz k\u00e9pezik a legfontosabb patogenetikai l\u00e9p\u00e9seket a m\u00e1jsejtk\u00e1rosod\u00e1sban. Tov\u00e1bbi fontos rizik\u00f3t\u00e9nyez\u0151 az or\u00e1lis fogamz\u00e1sg\u00e1tl\u00f3k elterjedt haszn\u00e1lata. Egyes foglalkoz\u00e1sok eset\u00e9n a tart\u00f3s szervesold\u00f3szer-expoz\u00edci\u00f3 is n\u00f6veli a HCC rizik\u00f3j\u00e1t. V\u00e9delmet jelenthetnek az antioxid\u00e1nsok, a szel\u00e9n, a gy\u00f3gyszerek k\u00f6z\u00fcl a statinok \u00e9s a feketek\u00e1v\u00e9-fogyaszt\u00e1s.<\/jats:p>","DOI":"10.1556\/oh.2010.28913","type":"journal-article","created":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T02:51:14Z","timestamp":1277261474000},"page":"1132-1136","source":"Crossref","is-referenced-by-count":8,"title":["Role of environmental factors in the etiology of hepatocellular carcinoma"],"prefix":"10.1556","volume":"151","author":[{"given":"Istv\u00e1n","family":"Tornai","sequence":"first","affiliation":[{"name":"1 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum Belgy\u00f3gy\u00e1szati Int\u00e9zet, Gasztroenterol\u00f3giai Tansz\u00e9k Debrecen Nagyerdei krt. 98. 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1470-2045(01)00486-7","volume":"2","year":"2001","journal-title":"Lancet Oncol."},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","volume":"132","year":"2007","journal-title":"Gastroenterology"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1053\/j.gastro.2004.09.008","volume":"127","year":"2004","journal-title":"Gastroenterology"},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1001\/archinte.160.21.3227","volume":"160","year":"2000","journal-title":"Arch. Int. Med."},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1053\/j.gastro.2004.09.020","volume":"127","year":"2004","journal-title":"Gastroenterology"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1053\/jhep.2002.36780","volume":"36","year":"2002","journal-title":"Hepatology"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/alcalc\/agh057","volume":"39","year":"2004","journal-title":"Alcohol & Alcoholism"},{"key":"atypb8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/aje\/155.4.323","volume":"155","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.7326\/0003-4819-133-6-200009190-00008","volume":"133","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1053\/jhep.2002.32101","volume":"35","year":"2002","journal-title":"Hepatology"},{"key":"atypb11","first-page":"2114s","volume":"52","year":"1992","journal-title":"Cancer Res."},{"key":"atypb12","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0140-6736(92)91528-G","volume":"339","year":"1992","journal-title":"Lancet"},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/350429a0","volume":"350","year":"1991","journal-title":"Nature"},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/oxfordjournals.aje.a009452","volume":"147","year":"1998","journal-title":"Am. J. Epidemiol."},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1002\/ijc.23730","volume":"123","year":"2008","journal-title":"Int. J. Cancer"},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1053\/j.gastro.2004.09.021","volume":"127","year":"2004","journal-title":"Gastroenterology"},{"key":"atypb17","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","volume":"348","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/hep.21103","volume":"43","year":"2006","journal-title":"Hepatology"},{"key":"atypb19","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/hep.21327","volume":"44","year":"2006","journal-title":"Hepatology"},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1111\/j.1572-0241.2001.04054.x","volume":"96","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"atypb21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1053\/j.gastro.2003.10.065","volume":"126","year":"2004","journal-title":"Gastroenterology"},{"key":"atypb22","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.5858\/132.11.1761","volume":"132","year":"2008","journal-title":"Arch. Pathol. Lab. Med."},{"key":"atypb23","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.3748\/wjg.14.5695","volume":"14","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0002-9440(10)63489-X","volume":"163","year":"2003","journal-title":"Am. J. Pathol."},{"key":"atypb25","first-page":"1301","volume":"55","year":"1995","journal-title":"Cancer Res."},{"key":"atypb26","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/oxfordjournals.aje.a009862","volume":"149","year":"1999","journal-title":"Am. J. Epidemiol."},{"key":"atypb27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/carcin\/17.1.145","volume":"17","year":"1996","journal-title":"Carcinogenesis"},{"key":"atypb28","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1016\/j.gastro.2004.09.018","volume":"127","year":"2004","journal-title":"Gastroenterology"},{"key":"atypb29","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jhep.2007.03.015","volume":"47","year":"2007","journal-title":"J. Hepatol."},{"key":"atypb30","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1002\/ijc.24309","volume":"124","year":"2009","journal-title":"Int. J. Cancer"},{"key":"atypb31","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1053\/j.gastro.2007.03.044","volume":"132","year":"2007","journal-title":"Gastroenterology"},{"key":"atypb32","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/hep.23097","volume":"50","year":"2009","journal-title":"Hepatology"},{"key":"atypb33","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1053\/j.gastro.2009.01.043","volume":"136","year":"2009","journal-title":"Gastroenterology"},{"key":"atypb34","first-page":"1601","volume":"138","year":"2009","journal-title":"Gastroenterology"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/151\/28\/article-p1132.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/151\/28\/article-p1132.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:29:54Z","timestamp":1635553794000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/151\/28\/article-p1132.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,1]]},"references-count":34,"journal-issue":{"issue":"28"},"URL":"https:\/\/doi.org\/10.1556\/oh.2010.28913","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,1]]}}}