{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T09:34:12Z","timestamp":1648978452444},"reference-count":9,"publisher":"Akademiai Kiado Zrt.","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:p>A B-sejtes prolymphocyt\u00e1s leukaemia ritka k\u00f3rk\u00e9p, kifejezett splenomegalia, lymphocytosis \u00e9s a csontvel\u0151 lymphoid sejtes infiltr\u00e1ci\u00f3ja jellemzi. Az egy\u00e9b lymphoproliferativ k\u00f3rk\u00e9pekt\u0151l a kering\u0151 prolymphocyt\u00e1k morfol\u00f3gi\u00e1ja \u00e9s immunfenot\u00edpusa (CD19, CD20, CD22, FMC7, intenz\u00edv felsz\u00edni immunglobulin-pozitivit\u00e1s) alapj\u00e1n k\u00fcl\u00f6n\u00edthet\u0151 el. Progn\u00f3zisa t\u00f6bbnyire kedvez\u0151tlen, kezel\u00e9se megoldatlan. A szerz\u0151k egy t\u00edpusos B-PLL-es beteg\u00fck k\u00f3rt\u00f6rt\u00e9net\u00e9t ismertetik, akiben FCR-Lite (fludarabin, cyclophosphamid, rituximab) protokoll alkalmaz\u00e1s\u00e1val komplett hematol\u00f3giai (\u00e9s flow citometriai) remisszi\u00f3 volt el\u00e9rhet\u0151. A kezel\u00e9st j\u00f3l toler\u00e1lta, infekci\u00f3, tumorlysis vagy egy\u00e9b sz\u00f6v\u0151dm\u00e9ny mostan\u00e1ig nem alakult ki. Tapasztalatuk szerint az FCR-Lite nemcsak a kr\u00f3nikus lymphoid leukaemia, hanem az (id\u0151sebb) B-PLL-es betegek kezel\u00e9s\u00e9re is aj\u00e1nlhat\u00f3. Az FCR-Lite sikeres alkalmaz\u00e1s\u00e1r\u00f3l B-PLL-ben tudom\u00e1suk szerint m\u00e9g nem sz\u00e1moltak be.<\/jats:p>","DOI":"10.1556\/oh.2010.28917","type":"journal-article","created":{"date-parts":[[2010,7,25]],"date-time":"2010-07-25T01:02:08Z","timestamp":1280019728000},"page":"1261-1263","source":"Crossref","is-referenced-by-count":1,"title":["Successful treatment of B-cell prolymphocytic leukemia (B-PLL) with FCR-Lite (fludarabine, cyclophosphamide, rituximab) protocol"],"prefix":"10.1556","volume":"151","author":[{"given":"B\u00e9la","family":"Telek","sequence":"first","affiliation":[{"name":"1 Debreceni Egyetem, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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