{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T11:17:43Z","timestamp":1713352663810},"reference-count":46,"publisher":"Akademiai Kiado Zrt.","issue":"37","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:p>Sz\u00e1mos k\u00f6zlem\u00e9ny besz\u00e1mol tumoros betegek \u00e9letmin\u0151s\u00e9g\u00e9nek jav\u00edt\u00e1s\u00e1ra alkalmazott \u00e9trend-kieg\u00e9sz\u00edt\u0151k hat\u00e1s\u00e1r\u00f3l, de mindezek \u00e9lettani vizsg\u00e1lata szeg\u00e9nyes. A c\u00e9kla sz\u00e1mos, a szervezetben lezajl\u00f3 biok\u00e9miai reakci\u00f3utat, enzim- \u00e9s metabolitszint\u00e9zist befoly\u00e1sol.<jats:italic>M\u00f3dszer:<\/jats:italic>A szerz\u0151k hormonrezisztens \u00e9s metasztatikus prosztatar\u00e1k miatt tax\u00e1n-kemoter\u00e1pi\u00e1ban r\u00e9szes\u00fcl\u0151 betegek \u00e9letmin\u0151s\u00e9g\u00e9nek jav\u00edt\u00e1sa \u00e9rdek\u00e9ben kereskedelmi forgalomb\u00f3l sz\u00e1rmaz\u00f3 term\u00e9szetes c\u00e9klak\u00e9sz\u00edtm\u00e9nyt adtak egy h\u00f3napon \u00e1t 2\u00d710 g d\u00f3zisban 24 (\u00e9letkor: 68\u00b18 \u00e9v) betegnek, akik 3,6\u00b12,8 \u00e9ve jelentkeztek el\u0151sz\u00f6r panaszaikkal. A kezel\u00e9st k\u00f6vet\u0151en 18 f\u0151 eset\u00e9ben tudt\u00e1k az adatokat ki\u00e9rt\u00e9kelni. A rutin laborat\u00f3riumi vizsg\u00e1latok mellett a betegek PSA-, HbA<jats:sub>1c<\/jats:sub>-\u00e9rt\u00e9keit, 9 citokin- \u00e9s 3 n\u00f6veked\u00e9sifaktor-szintet, a redox-homeoszt\u00e1zis glob\u00e1lis param\u00e9tereit, f\u00e9mionh\u00e1ztart\u00e1suk n\u00e9h\u00e1ny elem\u00e9t, Zn- \u00e9s szabadprotoporfirin-szintj\u00e9t, transzmetil\u00e1l\u00f3 k\u00e9pess\u00e9g\u00e9t a kezel\u00e9s megkezd\u00e9se el\u0151tt \u00e9s egy h\u00f3nap m\u00falva hat\u00e1rozt\u00e1k meg.<jats:italic>Eredm\u00e9nyek:<\/jats:italic>Eredm\u00e9nyeik azt mutatt\u00e1k, hogy a betegek d\u00f6nt\u0151 t\u00f6bbs\u00e9g\u00e9ben a c\u00e9kla kedvez\u0151 hat\u00e1sa \u00e9rv\u00e9nyre jutott, \u00e9s a tumoros betegekre jellemz\u0151 szignifik\u00e1nsan magas Zn- \u00e9s szabadprotoporfirin-szintek cs\u00f6kkentek, valamint a transzmetilez\u00e9si folyamatok felgyorsultak.<jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>Eredm\u00e9nyeik alapj\u00e1n \u00fagy t\u0171nik, hogy az \u00e1ltaluk alkalmazott c\u00e9klak\u00e9sz\u00edtm\u00e9ny m\u00e9rs\u00e9kelt \u00e9s tart\u00f3s fogyaszt\u00e1sa kedvez\u0151en befoly\u00e1solja a betegek \u00e9letmin\u0151s\u00e9g\u00e9t, de t\u00f6bb esetben megfigyelhet\u0151 n\u00f6vekv\u0151 EGF-\u00e9rt\u00e9k miatt szoros orvosi kontroll sz\u00fcks\u00e9ges kemoter\u00e1pi\u00e1ban r\u00e9szes\u00fcl\u0151 prosztatar\u00e1kos betegekn\u00e9l. Orv. Hetil., 2010, 37, 1495\u20131503.<\/jats:p>","DOI":"10.1556\/oh.2010.28918","type":"journal-article","created":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T02:56:10Z","timestamp":1283309770000},"page":"1495-1503","source":"Crossref","is-referenced-by-count":5,"title":["Effects of bioactive molecules of Beta vulgaris L. ssp. esculenta var. rubra on metastatic prostate cancer"],"prefix":"10.1556","volume":"151","author":[{"given":"P\u00e9ter","family":"Nyir\u00e1dy","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Urol\u00f3giai Klinika \u00e9s Uroonkol\u00f3giai Centrum Budapest \u00dcll\u0151i \u00fat 78\/B 1082"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"S\u00e1rdi","sequence":"additional","affiliation":[{"name":"4 Corvinus Egyetem, Kert\u00e9szettudom\u00e1nyi Kar Genetika \u00e9s N\u00f6v\u00e9nynemes\u00edt\u00e9si Tansz\u00e9k Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Bek\u0151","sequence":"additional","affiliation":[{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar K\u00f6zponti Laborat\u00f3rium Pest Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Sz\u0171cs","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Urol\u00f3giai Klinika \u00e9s Uroonkol\u00f3giai Centrum Budapest \u00dcll\u0151i \u00fat 78\/B 1082"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Urol\u00f3giai Klinika \u00e9s Uroonkol\u00f3giai Centrum Budapest \u00dcll\u0151i \u00fat 78\/B 1082"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edit","family":"Sz\u00e9kely","sequence":"additional","affiliation":[{"name":"5 Semmelweis Egyetem, Gy\u00f3gyszer\u00e9sztudom\u00e1nyi Kar Farmakogn\u00f3ziai Int\u00e9zet Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kl\u00e1ra","family":"Szentmih\u00e1lyi","sequence":"additional","affiliation":[{"name":"6 Magyar Tudom\u00e1nyos Akad\u00e9mia K\u00e9miai Kutat\u00f3k\u00f6zpont Anyag- \u00e9s K\u00f6rnyezetk\u00e9miai Int\u00e9zet Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imre","family":"Romics","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Urol\u00f3giai Klinika \u00e9s Uroonkol\u00f3giai Centrum Budapest \u00dcll\u0151i \u00fat 78\/B 1082"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bl\u00e1zovics","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","first-page":"5","volume":"171","year":"2004","journal-title":"J. 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J."},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1021\/tx0200663","volume":"15","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0171-2985(97)80025-3","volume":"198","year":"1997","journal-title":"Immunbiol."},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0009-2797(94)90029-9","volume":"91","year":"1994","journal-title":"Chem. Biol. Interact."},{"key":"atypb12","first-page":"329","volume":"38","year":"1997","journal-title":"Adv. Pharmacol."},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1006\/bbrc.2000.3585","volume":"276","year":"2000","journal-title":"Biochem. Biophys. Res. 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Urol."},{"key":"atypb20","volume-title":"Protein methylation","year":"1990"},{"key":"atypb21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/25779","volume":"395","year":"1998","journal-title":"Nature"},{"key":"atypb22","first-page":"1410","volume":"12","year":"2003","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"atypb23","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1182\/blood.V92.3.996","volume":"92","year":"1998","journal-title":"Blood"},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1054\/plef.2000.0174","volume":"63","year":"2000","journal-title":"Prostaglandins, Leukotrienes and Essential Fatty Acids"},{"key":"atypb25","first-page":"335","volume":"7","year":"1998","journal-title":"Cancer Epidemol. Biomarkers Prev."},{"key":"atypb26","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1006\/abbi.2000.1742","volume":"376","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"atypb27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.nut.2006.11.004","volume":"23","year":"2007","journal-title":"Nutrition"},{"key":"atypb28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1556\/AAlim.38.2009.3.1","volume":"38","year":"2009","journal-title":"Acta Alim."},{"key":"atypb29","first-page":"3","volume":"5","year":"1999","journal-title":"Int. J. Horticult. Sci."},{"key":"atypb30","first-page":"175","volume":"44","year":"2006","journal-title":"Clin. Chem. Lab. Med."},{"key":"atypb31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.5264\/eiyogakuzashi.44.307","volume":"44","year":"1986","journal-title":"Jpn. J. Nutr."},{"key":"atypb32","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1248\/cpb.36.2090","volume":"36","year":"1988","journal-title":"Chem. Pharm. Bull."},{"key":"atypb33","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/clinchem\/45.6.895","volume":"45","year":"1999","journal-title":"Clin. Chem."},{"key":"atypb34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/bmc.1130080614","volume":"8","year":"1994","journal-title":"Biomed. Chromatogr."},{"key":"atypb35","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1093\/clinchem\/21.11.1669","volume":"21","year":"1975","journal-title":"Clin. Chem."},{"key":"atypb36","volume-title":"Trace elements in the food chain, Vol. 3. Deficiency or excess of trace elements in the environment as a risk of health","year":"2009"},{"key":"atypb37","volume-title":"Elements and their compounds in the environment (Vol. 2)","year":"2004"},{"key":"atypb38","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1074\/jbc.M307649200","volume":"279","year":"2004","journal-title":"J. Biol. Chem."},{"key":"atypb39","first-page":"179","volume":"46","year":"2005","journal-title":"Rom. J. Morphol. Embryol."},{"key":"atypb40","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1038\/sj.bjc.6601814","volume":"90","year":"2004","journal-title":"Br. J. Cancer"},{"key":"atypb41","volume-title":"Trace elements in the food chain, Vol. 3. Deficiency or excess of trace elements in the environment as a risk of health","year":"2009"},{"key":"atypb42","first-page":"141","volume":"72","year":"1998","journal-title":"Adv. Cancer Res."},{"key":"atypb43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nrc1799","volume":"6","year":"2006","journal-title":"Nat. Rev. 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