{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T23:56:36Z","timestamp":1649030196630},"reference-count":22,"publisher":"Akademiai Kiado Zrt.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:p>A hepcidin a vasfelsz\u00edv\u00f3d\u00e1st \u00e9s a plazmavasszintet k\u00f6zvetlen\u00fcl cs\u00f6kkent\u0151 endog\u00e9n vegy\u00fclet. Technikai okok miatt meghat\u00e1roz\u00e1sa nem terjedt el, klinikai jelent\u0151s\u00e9g\u00e9re vonatkoz\u00f3an korl\u00e1tozottak az adatok. Munk\u00e1nk sor\u00e1n n\u0151 gy\u00f3gy\u00e1szati m\u0171t\u00e9tek kapcs\u00e1n elemezt\u00fck a bek\u00f6vetkez\u0151 hepcidinszint-v\u00e1ltoz\u00e1st. Vizsg\u00e1latunk sor\u00e1n 17 n\u0151gy\u00f3gy\u00e1 szati m\u0171t\u00e9ten \u00e1tesett n\u0151 eset\u00e9ben a m\u0171t\u00e9t el\u0151tt k\u00f6zvetlen\u00fcl, majd azt k\u00f6vet\u0151en 3 nappal vett v\u00e9rmint\u00e1ban hat\u00e1roztuk meg t\u00f6megspektrometri\u00e1val a hepcidinszintet, valamint ELISA-m\u00f3dszerrel a legfontosabb hepcidininduktor, az interleukin-6 szintj\u00e9t. A m\u0171t\u00e9t ut\u00e1n cs\u00f6kkent a sz\u00e9rumvasszint [medi\u00e1n, interkvartilis (17,85 [15,25\u201324,9] versus 10,1 [7,6\u201315,0] \u03bcmol\/L, p&lt;0,01)] \u00e9s transzferrinszint [60,3 (55,93\u201367,18) versus 53,1 (49,7\u201360,0) \u03bcmol\/L, p&lt;0,01], m\u00edg n\u0151tt a hepcidinszint [2,75 (2,24\u20133,51) versus 8,01 (6,8\u20139,67) \u03bcg\/L, p&lt;0,01) \u00e9s az interleukin-6-szint (ND \u2013 nem detekt\u00e1lhat\u00f3) [ND [ND \u2013 2.2] versus 8,15 (2,31\u201312,86), p&lt;0,01]. \n <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n A m\u0171t\u00e9tet k\u00f6vet\u0151 vasanyagcsere-v\u00e1ltoz\u00e1sokkal egyidej\u0171leg a hepcidinszint \u2013 hasonl\u00f3an m\u00e1s akutf\u00e1zis-feh\u00e9rj\u00e9khez \u2013 gyorsan emelkedik. Eredm\u00e9nyeink alapj\u00e1n a hepcidinszint emelked\u00e9se \u00e9s a vasszint cs\u00f6kken\u00e9se k\u00f6z\u00f6tti ok-okozati kapcsolat val\u00f3sz\u00edn\u0171s\u00edthet\u0151. A hepcidinszint m\u00e9r\u00e9s\u00e9nek a mindennapos gyakorlatban a m\u0171t\u00e9tet k\u00f6vet\u0151 vasanyagcsere-v\u00e1ltoz\u00e1s monitoroz\u00e1s\u00e1ban, esetleges el\u0151rejelz\u00e9s\u00e9ben lehet szerepe. Elterjed\u00e9se azonban rutin laborat\u00f3riumi tesztek hi\u00e1ny\u00e1ban egyel\u0151re nem val\u00f3sz\u00edn\u0171. Orv. Hetil., 2010, \n <jats:italic>43,<\/jats:italic>\n 1790\u20131794.<\/jats:p>","DOI":"10.1556\/oh.2010.28922","type":"journal-article","created":{"date-parts":[[2010,10,13]],"date-time":"2010-10-13T07:05:08Z","timestamp":1286953508000},"page":"1790-1794","source":"Crossref","is-referenced-by-count":0,"title":["Increased hepcidin levels three days after gynecological interventions"],"prefix":"10.1556","volume":"151","author":[{"given":"B\u00e9la","family":"Gyarmati","sequence":"first","affiliation":[{"name":"1 F\u0151v\u00e1rosi \u00d6nkorm\u00e1nyzat Uzsoki Utcai K\u00f3rh\u00e1z Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. 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