{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:15:51Z","timestamp":1787022951117,"version":"build-2736575974"},"reference-count":10,"publisher":"Akademiai Kiado Zrt.","issue":"35","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,1]]},"abstract":"<jats:p>A hepatocellularis carcinoma korai st\u00e1dium\u00e1ban t\u00fcnetszeg\u00e9ny betegs\u00e9g. A daganatsz\u00f6vet n\u00f6veked\u00e9se \u00e9s az erekbe t\u00f6rt\u00e9n\u0151 bet\u00f6r\u00e9se okoz \u00e1ltal\u00e1nos \u00e9s lok\u00e1lis t\u00fcneteket. Hasi diszkomfort, cachexia, az addig kompenz\u00e1lt cirrhosis ter\u00e1piarezisztens dekompenz\u00e1ci\u00f3ja, s\u00falyos esetben a vena portae vagy a hepaticus v\u00e9n\u00e1k thrombosisa jelzi a betegs\u00e9g progresszi\u00f3j\u00e1t. A laborat\u00f3riumi leletek k\u00f6z\u00fcl a v\u00e9rk\u00e9p a m\u00e1jfunkci\u00f3, a haemostasis, a sz\u00e9nhidr\u00e1t- \u00e9s a kalciumanyagcsere eredm\u00e9nyek gyors roml\u00e1sa jellemz\u0151. Az etiol\u00f3gia tiszt\u00e1z\u00e1s\u00e1hoz \u00e9s a magas rizik\u00f3j\u00fa betegek kisz\u0171r\u00e9s\u00e9hez az alkohol, a gy\u00f3gyszer- \u00e9s a vegyszer\u00e1rtalom, a B-, C-, delta v\u00edrushepatitisek, az anyagcsere-betegs\u00e9gek \u00e9s a nem alkoholos steatohepatitis vizsg\u00e1latai vezetnek. M\u00e1jg\u00f3c eset\u00e9n diagnosztikus \u00e9rt\u00e9k\u0171 a perziszt\u00e1l\u00f3an magas alfa-foetoprotein, 200 ng\/ml felett &gt;90% a pozit\u00edv predikt\u00edv \u00e9rt\u00e9ke. A mindennapi gyakorlatban ritk\u00e1bban m\u00e9rt biomarkerek a glikozil\u00e1lt alfa-foetoprotein-L3 \u00e9s a K-vitamin-hi\u00e1ny induk\u00e1lta des-gamma-karboxi-protrombin. HBeAg-pozit\u00edv kr\u00f3nikus B-hepatitises betegekben t\u00f6bbsz\u00f6r\u00f6s a tumormegjelen\u00e9s val\u00f3sz\u00edn\u0171s\u00e9ge, ha C genot\u00edpus\u00fa, a precore r\u00e9gi\u00f3j\u00e1ban az 1762 \u00e9s az 1764 helyen kett\u0151s mut\u00e1ci\u00f3t tartalmaz\u00f3 B v\u00edrussal fert\u0151z\u00f6ttek. A magas rizik\u00f3j\u00fa betegekn\u00e9l 6 havonta, tiszt\u00e1zatlan dignit\u00e1s\u00fa, 1 cm alatti m\u00e1jg\u00f3c eset\u00e9n 18\u201324 h\u00f3napon kereszt\u00fcl 3-4 havonta hasi ultrahangvizsg\u00e1lat \u00e9s alfa-foetoprotein-m\u00e9r\u00e9s javasolt.<\/jats:p>","DOI":"10.1556\/oh.2010.28945","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T21:06:29Z","timestamp":1282165589000},"page":"1415-1417","source":"Crossref","is-referenced-by-count":7,"title":["Symptoms of hepatocellular carcinoma. Laboratory tests used for its diagnosis and screening"],"prefix":"10.1556","volume":"151","author":[{"given":"Judit","family":"Gervain","sequence":"first","affiliation":[{"name":"1 Feh\u00e9r Megyei Szent Gy\u00f6rgy K\u00f3rh\u00e1z IV. Belgy\u00f3gy\u00e1szat \u00e9s Molekul\u00e1ris Diagnosztikai Laborat\u00f3rium Sz\u00e9kesfeh\u00e9rv\u00e1r Sereg\u00e9lyesi \u00fat 3. 8000"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"atypb1","volume-title":"Principles and Practice of Gastrointestinal Oncology","year":"2008"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"S223","DOI":"10.1016\/S1590-8658(10)60509-9","volume":"42","year":"2010","journal-title":"Dig Liv Dis."},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0168-8278(00)00053-2","volume":"34","year":"2001","journal-title":"J. Hepatol."},{"key":"atypb4","volume-title":"Principles and practice of gastrointestinal oncology","year":"2008"},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1056\/NEJMoa013215","volume":"347","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/hep.20365","volume":"40","year":"2004","journal-title":"Hepatology"},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1136\/gut.2003.033324","volume":"53","year":"2004","journal-title":"Gut"},{"key":"atypb8","first-page":"417","volume":"130","year":"2004","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0002-9343(96)00197-0","volume":"101","year":"1996","journal-title":"Am. J. Med."},{"key":"atypb10","first-page":"1159","volume":"19","year":"2004","journal-title":"Ther"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/151\/35\/article-p1415.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/151\/35\/article-p1415.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T06:20:10Z","timestamp":1590560410000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/151\/35\/article-p1415.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,1]]},"references-count":10,"journal-issue":{"issue":"35"},"URL":"https:\/\/doi.org\/10.1556\/oh.2010.28945","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,1]]}}}