{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T06:10:52Z","timestamp":1685859052092},"reference-count":32,"publisher":"Akademiai Kiado Zrt.","issue":"47","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:p>Sz\u00e1mos neuropeptidr\u0151l felt\u00e9telezik, hogy r\u00e9szt vesz a gyomorny\u00e1lkah\u00e1rtya v\u00e9delm\u00e9ben \u00e9s szerepet j\u00e1tszik a kr\u00f3nikus gastritis kialak\u00edt\u00e1s\u00e1ban.<jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic>Arra kerest\u00fcnk v\u00e1laszt, hogy van-e morfol\u00f3giai kapcsolat az idegrostok \u00e9s az immunkompetens sejtek k\u00f6z\u00f6tt, termelnek-e az immunsejtek is neuropeptideket, valamint l\u00e9tezik-e kolokaliz\u00e1ci\u00f3 TNF-\u03b1-val \u00e9s NF-\u03ba-B-vel.<jats:italic>M\u00f3dszer:<\/jats:italic>Immunhisztok\u00e9miai, konfok\u00e1lis l\u00e9zer- \u00e9s elektronmikroszk\u00f3ppal vizsg\u00e1ltuk az idegrostokat \u00e9s immunkompetens sejteket \u00e9p \u00e9s gastritises ny\u00e1lkah\u00e1rty\u00e1ban.<jats:italic>Eredm\u00e9nyek:<\/jats:italic>Gyullad\u00e1s hat\u00e1s\u00e1ra a neuropeptid-tartalm\u00fa idegrostok sz\u00e1ma szignifik\u00e1nsan megemelkedett. Az \u00e9p gyomorny\u00e1lkah\u00e1rty\u00e1ban a lymphocyt\u00e1k, plazmasejtek, h\u00edz\u00f3sejtek mennyis\u00e9ge alacsony \u00e9s soha sem mutatott immunfest\u00e9st ezen neuropeptid-ellenanyagokra. Azonban gastritisben az immunkompetens sejtek egy r\u00e9sze SP- \u00e9s NPY-immunreaktivit\u00e1st mutatott. Ezen sejtekben az SP kolokaliz\u00e1ci\u00f3ban fordult el\u0151 a TNF-\u03b1-val \u00e9s NF-\u03ba-B-vel. Az immunsejtek \u00e9s a jelzett idegrostok k\u00f6z\u00f6tti t\u00e1vols\u00e1g 1 \u00b5m vagy enn\u00e9l is kevesebb volt.<jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic>Az idegrostokb\u00f3l \u00e9s az immunkompetens sejtekb\u0151l felszabadul\u00f3 medi\u00e1torok r\u00e9szt vesznek a neurog\u00e9n gyullad\u00e1s kialakul\u00e1s\u00e1ban, a kr\u00f3nikus gastritis fenntart\u00e1s\u00e1ban. Orv. 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