{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T21:20:44Z","timestamp":1649193644889},"reference-count":38,"publisher":"Akademiai Kiado Zrt.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:p>A hepatocellularis carcinoma k\u00f3rj\u00f3slata rossz. A felismer\u00e9skor a betegek 85%-a nem alkalmas a kurat\u00edv kezel\u00e9sre, ezekben az esetekben a palliat\u00edv m\u00f3dozatok, a transarterialis kemoembolisatio, a r\u00e1di\u00f3frekvenci\u00e1s ablatio \u00e9s a sziszt\u00e9m\u00e1s kemoter\u00e1pia alkalmazhat\u00f3ak. A sziszt\u00e9m\u00e1s kemoter\u00e1pia eredm\u00e9nyei ki\u00e1br\u00e1nd\u00edt\u00f3ak. Molekul\u00e1ris biol\u00f3giai ismereteink a c\u00e9lzott kezel\u00e9si lehet\u0151s\u00e9gek t\u00e1r\u00e1t b\u0151v\u00edthetik a j\u00f6v\u0151ben. Jelenleg a multikin\u00e1zg\u00e1tl\u00f3 sorafenib van csak t\u00f6rzsk\u00f6nyvezve haz\u00e1nkban, de \u00edg\u00e9retesek lehetnek m\u00e9g a VEGF-g\u00e1tl\u00f3k (bevacizumab, sunitinib), az EGFR-\u00fatvonal g\u00e1tl\u00e1sa (erlotinib), valamint az mTOR-g\u00e1tl\u00f3k (rapamycin \u00e9s sz\u00e1rmaz\u00e9kai). El\u0151ny\u00f6s lehet a sorafenib vagy m\u00e1s \u00e9rk\u00e9pz\u0151d\u00e9st g\u00e1tl\u00f3 egy\u00fcttes ad\u00e1sa helyi ablat\u00edv elj\u00e1r\u00e1sokkal (transarterialis kemoembolisatio, r\u00e1di\u00f3frekvenci\u00e1s ablatio) vagy kurat\u00edv hepatectomi\u00e1val. A j\u00f6v\u0151 tov\u00e1bbi lehet\u0151s\u00e9gei k\u00f6z\u00e9 tartoznak a Wnt-\u00fatvonalat m\u00f3dos\u00edt\u00f3k, a retinoid vegy\u00fcletek, a sejtciklusg\u00e1tl\u00f3k, a proteosz\u00f3mag\u00e1tl\u00f3k \u00e9s az epigenetikus kezel\u00e9s. Orv. 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