{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T11:33:13Z","timestamp":1648985593856},"reference-count":52,"publisher":"Akademiai Kiado Zrt.","issue":"46","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:p>A szerz\u0151k a carcinoid tumorokkal kapcsolatos legfontosabb klinikai gyakorlati ismeretekr\u0151l adnak \u00e1ttekint\u00e9st. A carcinoid daganatok neuroendokrin sejtekb\u0151l sz\u00e1rmaz\u00f3, t\u00f6bbs\u00e9g\u00e9ben lassan n\u00f6vekv\u0151 ritka tumorok, azonban gyorsan metasztatiz\u00e1l\u00f3, agressz\u00edv form\u00e1ban is jelentkezhetnek. Epidemiol\u00f3giai adatok szerint gyakoris\u00e1guk n\u0151, amit r\u00e9szben a diagnosztikus m\u00f3dszerek fejl\u0151d\u00e9se okozhat. A daganatok gyakran t\u00fcnetmentesek, m\u00e1skor carcinoid szindr\u00f3ma vagy egy\u00e9b endokrin szindr\u00f3m\u00e1k t\u00fcnetei lehetnek jelen. A korai diagn\u00f3zist biok\u00e9miai markerek (sz\u00e9rum-kromogranin-A, vizelet-5-hidroxi-indolecetsav) \u00e9s speci\u00e1lis k\u00e9palkot\u00f3 m\u00f3dszerek seg\u00edtik. A daganatok jelent\u0151s r\u00e9sz\u00e9t a betegs\u00e9g el\u0151rehaladott st\u00e1dium\u00e1ban ismerik fel; ezekben az esetekben seb\u00e9szi m\u00f3dszerekkel nem \u00e9rhet\u0151 el teljes gy\u00f3gyul\u00e1s, b\u00e1r a daganat megkisebb\u00edt\u00e9s\u00e9nek seb\u00e9szi vagy intervenci\u00f3s radiol\u00f3giai lehet\u0151s\u00e9geit ilyenkor is sz\u00e1m\u00edt\u00e1sba kell venni. A carcinoid tumorokhoz t\u00e1rsul\u00f3 klinikai t\u00fcnetek kezel\u00e9s\u00e9nek jelenleg leghat\u00e1sosabb eszk\u00f6zei a szomatosztatin-anal\u00f3g k\u00e9sz\u00edtm\u00e9nyek, amelyek a t\u00fcnetek megsz\u00fcntet\u00e9s\u00e9n\/enyh\u00edt\u00e9s\u00e9n k\u00edv\u00fcl tumorg\u00e1tl\u00f3 hat\u00e1suk r\u00e9v\u00e9n ak\u00e1r hossz\u00fa \u00e9veken kereszt\u00fcl kiv\u00e9dhetik a daganatok n\u00f6veked\u00e9s\u00e9t vagy ritk\u00e1n daganatregresszi\u00f3t v\u00e1lthatnak ki. A kemoter\u00e1pi\u00e1s k\u00e9sz\u00edtm\u00e9nyeket els\u0151sorban metasztatikus, agressz\u00edv, gyorsan n\u00f6vekv\u0151, illetve pancreas neuroendokrin daganatok eset\u00e9n alkalmaznak, klinikai vizsg\u00e1latokban \u00faj kemoter\u00e1pi\u00e1s lehet\u0151s\u00e9gk\u00e9nt a temozolomid \u00e9s a thalidomid ad\u00e1s\u00e1val szereztek kedvez\u0151 kezdeti tapasztalatokat. Progressz\u00edv, el\u0151rehaladt st\u00e1dium\u00fa daganatban szenved\u0151 betegek r\u00e9sz\u00e9re hat\u00e9kony \u00faj ter\u00e1pi\u00e1s lehet\u0151s\u00e9g a \n <jats:sup>131<\/jats:sup>\n I-MIBG, \n <jats:sup>90<\/jats:sup>\n Y-DOTA-TOC \u00e9s \n <jats:sup>177<\/jats:sup>\n Lu-DOTA-TOC radionuklid kezel\u00e9s. Kezdeti tapasztalatok \u00e1llnak rendelkez\u00e9sre a tirozinkin\u00e1z-g\u00e1tl\u00f3k, tirozinkin\u00e1z-ellenes antitestek \u00e9s a \u201emammalian target of rapamycin\u201d (mTOR) g\u00e1tl\u00f3k alkalmaz\u00e1s\u00e1r\u00f3l, amelyek k\u00f6z\u00fcl a hat\u00e9konynak bizonyul\u00f3 k\u00e9sz\u00edtm\u00e9nyek a j\u00f6v\u0151ben sz\u00e9lesebb k\u00f6r\u0171 alkalmaz\u00e1st nyerhetnek. Orv. Hetil., 2010, \n <jats:italic>46,<\/jats:italic>\n 1885\u20131894.<\/jats:p>","DOI":"10.1556\/oh.2010.29000","type":"journal-article","created":{"date-parts":[[2010,11,16]],"date-time":"2010-11-16T02:08:26Z","timestamp":1289873306000},"page":"1885-1894","source":"Crossref","is-referenced-by-count":1,"title":["Carcinoid tumors"],"prefix":"10.1556","volume":"151","author":[{"given":"Istv\u00e1n","family":"Pregun","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Bodoky","sequence":"additional","affiliation":[{"name":"2 F\u0151v\u00e1rosi \u00d6nkorm\u00e1nyzat Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Onkol\u00f3giai Oszt\u00e1ly Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1roly","family":"R\u00e1cz","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Tulassay","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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