{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:30:08Z","timestamp":1766068208230},"reference-count":71,"publisher":"Akademiai Kiado Zrt.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p>The coincidence of systemic autoimmune diseases and pregnancy may modify the outcome of the disease and the pregnancy due to the background immunologic and hormonal processes. The great majority of patients with autoimmune diseases are young females in their reproductive ages willing to have babies. Consequently we have to prepare for this special situation. Our concept on childbearing in autoimmune women has changed within the last 30 years. Earlier, systemic lupus erythematosus flared in about 50% of patients during pregnancy, but the flare rate has significantly decreased recently. This improvement can be attributed to increased attention to low diseases activity at the time of conception, which might reduce to the half of the risk for flare. Tight control of patients and appropriate use of corticosteroids also contribute to the better results. The adequate use of anti-thrombotic agents resulted in a significant amelioration of pregnancy outcome in antiphospholipid syndrome. The earlier use of methotrexate and the introduction of tumor necrosis factor-alpha inhibitors in the treatment of rheumatoid arthritis have changed the natural characteristics of the disease. The increase in remission rate indirectly has beneficial effect on the number of planned and carried out pregnancies. Authors review the connection between systemic autoimmune disorders and pregnancy as well as the possibilities of medical treatment of such diseases during pregnancy. Orv. Hetil., 2011, 152, 1715\u20131723.<\/jats:p>","DOI":"10.1556\/oh.2011.29216","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T01:06:47Z","timestamp":1318295207000},"page":"1715-1723","source":"Crossref","is-referenced-by-count":0,"title":["Systemic autoimmune disorders and pregnancy"],"prefix":"10.1556","volume":"152","author":[{"given":"Emese","family":"Kiss","sequence":"first","affiliation":[{"name":"Orsz\u00e1gos Reumatol\u00f3giai \u00e9s Fizioter\u00e1pi\u00e1s Int\u00e9zet Budapest Frankel Le\u00f3 \u00fat 38\u201340. 1023"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar III. Belgy\u00f3gy\u00e1szati Klinika, II. Reumatol\u00f3giai Tansz\u00e9ki Csoport Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba Gy\u00f6rgy","family":"Kiss","sequence":"additional","affiliation":[{"name":"Veszpr\u00e9m Megyei Csolnoky Ferenc K\u00f3rh\u00e1z Nonprofit Zrt. Veszpr\u00e9m"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyula","family":"Po\u00f3r","sequence":"additional","affiliation":[{"name":"Orsz\u00e1gos Reumatol\u00f3giai \u00e9s Fizioter\u00e1pi\u00e1s Int\u00e9zet Budapest Frankel Le\u00f3 \u00fat 38\u201340. 1023"},{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar III. Belgy\u00f3gy\u00e1szati Klinika, II. 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