{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:39:05Z","timestamp":1762004345588},"reference-count":8,"publisher":"Akademiai Kiado Zrt.","issue":"46","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p> Toll-like receptor 4, a central mediator of the innate immune response has been shown to play an important role not only in the defense mechanism against microorganism, but also other non-infectious inflammatory diseases such as atherosclerosis. The Asp299Gly and Thr399Ile, which are common co-segregation polymorphisms of the Toll-like receptor 4 gene have been shown to be associated with increased susceptibility for Gram-negative infections, but with a lower risk of carotid atherosclerosis and a reduced level of certain proinflammatory cytokines. Aim: The role of these polymorphisms in diabetes mellitus with its late microvascular complications, in ischemic stroke, and in chronic periodontitis was investigated in three independent studies. Methods: In all studies the alleles of both polymorphisms were detected by polymerase chain reaction and subsequent cleavage by restriction endonucleases followed by gel electrophoresis. Results: In patients with type 2 diabetes, heterozygote carriers of the Asp299Gly and Thr399Ile polymorphisms of the Toll-like receptor 4 gene had a significantly reduced prevalence of peripheral neuropathy, while there was no association with any other diabetic microvascular complication, or with cerebral ischemia or with chronic periodontitis. Conclusions: Toll-like receptor 4 gene polymorphisms are not enough sensitive genetic markers for risk stratification either in diabetes mellitus or in cerebral ischemia or in chronic periodontitis. Orv. Hetil., 2011, 152, 1855\u20131858. <\/jats:p>","DOI":"10.1556\/oh.2011.29243","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T01:06:14Z","timestamp":1319763974000},"page":"1855-1858","source":"Crossref","is-referenced-by-count":2,"title":["Study of the Toll-like receptor 4 gene polymorphisms in diseases presenting with subclinical and chronic inflammation"],"prefix":"10.1556","volume":"152","author":[{"given":"P\u00e9ter","family":"Reismann","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest Szentkir\u00e1lyi utca 46. 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1556\/OH.2008.28452","volume":"149","year":"2008","journal-title":"Orv. Hetil."},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1056\/NEJMoa012673","volume":"347","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/76048","volume":"25","year":"2000","journal-title":"Nat. Genet."},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.3748\/wjg.v11.i10.1489","volume":"11","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1161\/01.CIR.0000068311.40161.28","volume":"107","year":"2003","journal-title":"Circulation"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2337\/diacare.27.1.179","volume":"27","year":"2004","journal-title":"Diabetes Care"},{"key":"atypb7","first-page":"853","volume":"251","year":"2004","journal-title":"J. Neurol."},{"key":"atypb8","first-page":"41","volume":"4","year":"2007","journal-title":"Perio"}],"container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/OH.2011.29243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:50:37Z","timestamp":1590141037000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/oh.2011.29243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":8,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1556\/OH.2011.29243"],"URL":"https:\/\/doi.org\/10.1556\/oh.2011.29243","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}