{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:48:52Z","timestamp":1648763332140},"reference-count":23,"publisher":"Akademiai Kiado Zrt.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Introduction: Measurement of plasma aldosterone\/renin ratio is the key step in the diagnosis of primary aldosteronism. Aim: The aim of the authors was to analyze and compare the diagnostic utility of plasma aldosterone\/renin activity and plasma aldosterone\/renin concentration ratios. Methods: Plasma aldosterone and plasma renin activity were determined by radioimmunoassays and plasma renin concentration was measured by immunoradiometric assay in 134 subjects (80 women and 54 men, aged 46\u00b115.5 years) including 49 healthy blood donors (control group), 59 patients with hypertension (25 treated and 34 untreated) and 26 patients with incidentally discovered adrenal adenomas. Results: There was a weak correlation (r = 0.59) between plasma renin activity and plasma renin concentration in the lower range (plasma renin activity, 0.63\u00b10.41 ng\/ml\/h; plasma renin concentration, 8.1\u00b14.9 ng\/l). Considering the cut-off value of plasma aldosterone\/renin ratios determined in controls (plasma aldosterone\/renin activity ratio, 30 ng\/dl\/ng\/ml\/h; plasma aldosterone\/renin concentration ratio, 3.0 ng\/dl\/ng\/l), high proportion of falsely positive results were found among patients on beta-receptor blocker therapy (plasma aldosterone\/renin activity ratio, 22.2%; plasma aldosterone\/renin concentration ratio, 44.4%) Conclusion: The widely used plasma aldosterone\/renin activity ratio can only be replaced with plasma aldosterone\/renin concentration ratio with precaution on different clinical conditions. Orv. Hetil., 2012, 153, 1701\u20131710.<\/jats:p>","DOI":"10.1556\/oh.2012.29476","type":"journal-article","created":{"date-parts":[[2012,10,23]],"date-time":"2012-10-23T02:19:30Z","timestamp":1350958770000},"page":"1701-1710","source":"Crossref","is-referenced-by-count":1,"title":["Clinical evaluation of the renin-aldosterone system: Comparison of two methods in different clinical conditions"],"prefix":"10.1556","volume":"153","author":[{"given":"D\u00f3ra","family":"Horv\u00e1th","sequence":"first","affiliation":[{"name":"Vas Megyei Markusovszky K\u00f3rh\u00e1z, Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Nonprofit Zrt. \u00c1ltal\u00e1nos Belgy\u00f3gy\u00e1szati Oszt\u00e1ly Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"L\u0151csei","sequence":"additional","affiliation":[{"name":"Vas Megyei Markusovszky K\u00f3rh\u00e1z, Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Nonprofit Zrt. \u00c1ltal\u00e1nos Belgy\u00f3gy\u00e1szati Oszt\u00e1ly Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Csizmadia","sequence":"additional","affiliation":[{"name":"Vas Megyei Markusovszky K\u00f3rh\u00e1z, Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Nonprofit Zrt. K\u00f6zponti Laborat\u00f3rium Szombathely Markusovszky L. u. 5. 9700"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet","family":"Toldy","sequence":"additional","affiliation":[{"name":"Vas Megyei Markusovszky K\u00f3rh\u00e1z, Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Nonprofit Zrt. K\u00f6zponti Laborat\u00f3rium Szombathely Markusovszky L. u. 5. 9700"},{"name":"P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar Diagnosztikai Int\u00e9zet, Gyakorlati Diagnosztikai Tansz\u00e9ki Csoport Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Szabolcs","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1roly","family":"R\u00e1cz","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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