{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:10:11Z","timestamp":1785888611725,"version":"3.56.0"},"reference-count":75,"publisher":"Akademiai Kiado Zrt.","issue":"48","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Human adenoviruses function as genetic models and vectors for gene therapy. Upper respiratory, gastrointestinal or ocular infections usually have mild course without any major complication in immuncompetent individuals. However, reactivation from latency in immuncompromised patients may lead to death. Depending on the underlying diseases, different adenovirus serotypes damage different organs. In children with severe combined immunodeficiency syndrome, serotypes of species A and C induce lung, liver or bladder inflammation. Paediatric hematopoietic stem cell transplantation is frequently followed by serotype 31-induced pneumonia, enteritis, cystitis. B serotypes can destroy transplanted organs. In AIDS patients, D and novel F serotypes cause enteritis. Recombinants of B serotypes induce urinary tract infections. Progression of lymphomas, tumours, and systemic lupus erythematosus might be facilitated by immunsuppressive effects of adenoviruses. As far as the diagnostic work-up of adenoviruses, detection of viral DNA and virus copy number is predictive, while serology testing is quite unrealiable. For treatment, cidofovir derivates, ribavirin, ganciclovir, vidarabine and microRNA have been used. Orv. Hetil., 2012, 153, 1896\u20131904.<\/jats:p>","DOI":"10.1556\/oh.2012.29496","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T18:11:04Z","timestamp":1354039864000},"page":"1896-1904","source":"Crossref","is-referenced-by-count":10,"title":["Adenovirus infections in immuncompromised patients"],"prefix":"10.1556","volume":"153","author":[{"given":"Bal\u00e1zs","family":"Stercz","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Orvosi Mikrobiol\u00f3giai Int\u00e9zet Budapest Nagyv\u00e1rad t\u00e9r 4. 1089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1roly","family":"Nagy","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Orvosi Mikrobiol\u00f3giai Int\u00e9zet Budapest Nagyv\u00e1rad t\u00e9r 4. 1089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Ongr\u00e1di","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Orvosi Mikrobiol\u00f3giai Int\u00e9zet Budapest Nagyv\u00e1rad t\u00e9r 4. 1089"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"e24491","DOI":"10.1371\/journal.pone.0024491","volume":"6","year":"2011","journal-title":"PLoS One"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/rmv.386","volume":"13","year":"2003","journal-title":"Rev. Med. Virol."},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2217\/fvl.11.6","volume":"6","year":"2011","journal-title":"Future Virol."},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1365-2141.2004.05218.x","volume":"128","year":"2005","journal-title":"Br. J. Haematol."},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.virol.2011.12.006","volume":"424","year":"2012","journal-title":"Virology"},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1128\/JVI.02392-08","volume":"83","year":"2009","journal-title":"J. Virol."},{"key":"atypb7","first-page":"173","volume":"41","year":"1994","journal-title":"Acta Microbiol. Immunol. Hung."},{"key":"atypb8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000149201","volume":"14","year":"1980","journal-title":"Intervirology"},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1586\/eri.11.113","volume":"9","year":"2011","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ymgme.2003.08.016","volume":"80","year":"2003","journal-title":"Mol. Genet. Metab."},{"key":"atypb11","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1097\/TP.0b013e31818b6548","volume":"86","year":"2008","journal-title":"Transplantation"},{"key":"atypb12","first-page":"1463","volume":"60","year":"1999","journal-title":"Am. J. Vet. Res."},{"key":"atypb13","first-page":"515","volume":"52","year":"2006","journal-title":"Clin. Lab."},{"key":"atypb14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1309\/AWXDGNC5D70EN7YT","volume":"120","year":"2003","journal-title":"Am. J. Clin. Pathol."},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1128\/CMR.5.3.262","volume":"5","year":"1992","journal-title":"Clin. Microbiol. Rev."},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/BF02887577","volume":"32","year":"1987","journal-title":"Folia Microbiol. (Praha)"},{"key":"atypb17","first-page":"51","volume":"41","year":"1994","journal-title":"Acta Microbiol. Immunol. Hung."},{"key":"atypb18","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/CMR.00052-07","volume":"21","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"atypb19","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/sj.bmt.1702656","volume":"26","year":"2000","journal-title":"Bone Marrow Transplant."},{"key":"atypb20","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/BF00442482","volume":"147","year":"1988","journal-title":"Eur. J. Pediatr."},{"key":"atypb21","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/0002-9343(81)90343-0","volume":"71","year":"1981","journal-title":"Am. J. Med."},{"key":"atypb22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/01.md.0000229482.27398.ad","volume":"85","year":"2006","journal-title":"Medicine (Baltimore)"},{"key":"atypb23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/mgme.1997.2651","volume":"63","year":"1998","journal-title":"Mol. Genet. Metab."},{"key":"atypb24","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/infdis\/169.4.775","volume":"169","year":"1994","journal-title":"J. Infect. Dis."},{"key":"atypb25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/sj.bmt.1705389","volume":"38","year":"2006","journal-title":"Bone Marrow Transplant."},{"key":"atypb26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jcv.2007.01.001","volume":"38","year":"2007","journal-title":"J. Clin. Virol."},{"key":"atypb27","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1182\/blood-2002-07-2152","volume":"102","year":"2003","journal-title":"Blood"},{"key":"atypb28","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1086\/341770","volume":"35","year":"2002","journal-title":"Clin. Infect. Dis."},{"key":"atypb29","first-page":"(Suppl. 4), S16","volume":"9","year":"2009","journal-title":"Am. J. Transplant."},{"key":"atypb30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1600-6143.2010.03408.x","volume":"11","year":"2011","journal-title":"Am. J. Transplant."},{"key":"atypb31","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1056\/NEJM200105173442002","volume":"344","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"atypb32","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1056\/NEJM200105173442010","volume":"344","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"atypb33","first-page":"106","volume":"114","year":"1990","journal-title":"Arch. Pathol. Lab. Med."},{"key":"atypb34","first-page":"787","volume":"53","year":"1978","journal-title":"S. Afr. Med. J."},{"key":"atypb35","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1399-3062.2010.00577.x","volume":"13","year":"2011","journal-title":"Transpl. Infect. Dis."},{"key":"atypb36","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5694\/j.1326-5377.1982.tb124174.x","volume":"1","year":"1982","journal-title":"Med. J. Aust."},{"key":"atypb37","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1600-6143.2011.03479.x","volume":"11","year":"2011","journal-title":"Am. J. Transplant."},{"key":"atypb38","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1097\/00007890-200104150-00029","volume":"71","year":"2001","journal-title":"Transplantation"},{"key":"atypb39","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1016\/j.transproceed.2004.10.090","volume":"36","year":"2004","journal-title":"Transplant. Proc."},{"key":"atypb40","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1148\/radiology.213.3.r99dc25735","volume":"213","year":"1999","journal-title":"Radiology"},{"key":"atypb41","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.healun.2007.06.009","volume":"26","year":"2007","journal-title":"J. Heart Lung Transplant."},{"key":"atypb42","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/01.TP.0000154911.15693.80","volume":"79","year":"2005","journal-title":"Transplantation"},{"key":"atypb43","first-page":"198","volume":"90","year":"2010","journal-title":"Transplantation"},{"key":"atypb44","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/infdis\/172.3.629","volume":"172","year":"1995","journal-title":"J. Infect. Dis."},{"key":"atypb45","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1128\/JCM.37.12.3940-3945.1999","volume":"37","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"atypb46","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1128\/JVI.63.11.4616-4625.1989","volume":"63","year":"1989","journal-title":"J. Virol."},{"key":"atypb47","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/infdis\/158.4.804","volume":"158","year":"1988","journal-title":"J. Infect. Dis."},{"key":"atypb48","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF02768003","volume":"26","year":"1994","journal-title":"Int. Urol. Nephrol."},{"key":"atypb49","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jcv.2010.09.021","volume":"50","year":"2011","journal-title":"J. Clin. Virol."},{"key":"atypb50","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/BOR.0b013e32833c6297","volume":"22","year":"2010","journal-title":"Curr. Opin. Rheumatol."},{"key":"atypb51","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1086\/313514","volume":"29","year":"1999","journal-title":"Clin. Infect. Dis."},{"key":"atypb52","first-page":"196","volume":"18","year":"2008","journal-title":"AIDS Read."},{"key":"atypb53","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1128\/JCM.41.2.810-812.2003","volume":"41","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"atypb54","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1128\/JCM.28.12.2659-2667.1990","volume":"28","year":"1990","journal-title":"J. Clin. Microbiol."},{"key":"atypb55","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1086\/340502","volume":"185","year":"2002","journal-title":"J. Infect. Dis."},{"key":"atypb56","first-page":"74","volume":"13","year":"2007","journal-title":"Biol. Blood Marrow Transplant."},{"key":"atypb57","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jviromet.2008.10.014","volume":"155","year":"2009","journal-title":"J. Virol. Methods"},{"key":"atypb58","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bbmt.2010.09.010","volume":"17","year":"2011","journal-title":"Biol. Blood Marrow Transplant."},{"key":"atypb59","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1053\/bbmt.2001.v7.pm11529489","volume":"7","year":"2001","journal-title":"Biol. Blood Marrow Transplant."},{"key":"atypb60","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1399-3062.2009.00452.x","volume":"12","year":"2010","journal-title":"Transpl. Infect. Dis."},{"key":"atypb61","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.3390\/ph3103343","volume":"3","year":"2010","journal-title":"Pharmaceuticals"},{"key":"atypb62","doi-asserted-by":"crossref","first-page":"7293","DOI":"10.1073\/pnas.0800200105","volume":"105","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"atypb63","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jcv.2010.10.016","volume":"50","year":"2011","journal-title":"J. Clin. Virol."},{"key":"atypb64","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.bbmt.2011.09.007","volume":"18","year":"2012","journal-title":"Biol. Blood Marrow Transplant."},{"key":"atypb65","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/135965350501000204","volume":"10","year":"2005","journal-title":"Antivir. Ther."},{"key":"atypb66","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1097\/00006454-200011000-00016","volume":"19","year":"2000","journal-title":"Pediatr. Infect. Dis. J."},{"key":"atypb67","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/sj.bmt.1701788","volume":"23","year":"1999","journal-title":"Bone Marrow Transplant."},{"key":"atypb68","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S1083-8791(03)00102-2","volume":"9","year":"2003","journal-title":"Biol. Blood Marrow Transplant."},{"key":"atypb69","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/095632020401500507","volume":"15","year":"2004","journal-title":"Antivir. Chem. Chemother."},{"key":"atypb70","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/sj.bmt.1700923","volume":"20","year":"1997","journal-title":"Bone Marrow Transplant."},{"key":"atypb71","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1086\/319984","volume":"32","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"atypb72","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/jac\/dki168","volume":"56","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"atypb73","doi-asserted-by":"crossref","first-page":"e1000440","DOI":"10.1371\/journal.ppat.1000440","volume":"5","year":"2009","journal-title":"PLoS Pathog."},{"key":"atypb74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.11.1.1","volume":"11","year":"1998","journal-title":"Clin. Microbiol. Rev."},{"key":"atypb75","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.exphem.2003.12.009","volume":"32","year":"2004","journal-title":"Exp. Hematol."}],"container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/OH.2012.29496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T04:58:24Z","timestamp":1687841904000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/oh.2012.29496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":75,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1556\/OH.2012.29496"],"URL":"https:\/\/doi.org\/10.1556\/oh.2012.29496","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}