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The primarily affected molecular pathways are Ras-MAPK signalling, hypoxia induced factor 1\u03b1, and mTOR signalling that are also involved in sporadic tumours and may even represent potential molecular targets of therapy. In this review, the major characteristics of hereditary tumour syndromes, their molecular genetics and the pathophysiological mechanisms involved in sporadic tumours are discussed. Orv. Hetil., 2013, 154, 1541\u20131548.<\/jats:p>","DOI":"10.1556\/oh.2013.29706","type":"journal-article","created":{"date-parts":[[2013,9,22]],"date-time":"2013-09-22T01:01:29Z","timestamp":1379811689000},"page":"1541-1548","source":"Crossref","is-referenced-by-count":3,"title":["Genetics of neuroendocrine tumours, hereditary tumour syndromes"],"prefix":"10.1556","volume":"154","author":[{"given":"P\u00e9ter","family":"Igaz","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. 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