{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T11:57:52Z","timestamp":1715169472018},"reference-count":14,"publisher":"Akademiai Kiado Zrt.","issue":"49","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p> Introduction: Tumor necrosis factor-alpha inhibitors are increasingly used in the treatment of severe Crohn\u2019s disease. Aim: The aim of the authors was to assess retrospectively the short and long term efficacy of tumor necrosis factor-alpha inhibitors in fistulising Crohn\u2019s disease. Method: Responses to therapy was determined using Crohn\u2019s Disease Activity Index, Perianal Disease Activity Index, the rate of complete fistula closure and the additional surgical procedures during biological therapy. Results: After 12 weeks the perianal activity was decreased in more than 80% of the cases, and the complete remission rate was about 60%. After one year of therapy about one third of the patients had fistula closure, but after cessation of the biological therapy recurrence of fistulas was detected in every second patient. In most cases additional immunosuppressive therapy was necessary during biological treatment. During the one-year therapy period additional surgical treatments were performed in 45% of patients; seton insertion and abscess drainage were the most frequent procedures. Conclusions: Tumor necrosis factor-alpha inhibitor therapy is effective in the treatment of perianal Crohn\u2019s disease, however, additional immunosuppressive drugs and rectum sparing surgical procedures were necessary during the one-year treatment period. Because of the high rate of fistula recurrence, long term tumor necrosis factor-alpha treatment may be useful. Orv. Hetil., 154(49), 1943\u20131948. <\/jats:p>","DOI":"10.1556\/oh.2013.29770","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T02:00:51Z","timestamp":1385949651000},"page":"1943-1948","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy of tumor necrosis factor-alpha inhibitors in fistulising perianal Crohn\u2019s disease"],"prefix":"10.1556","volume":"154","author":[{"given":"Ren\u00e1ta","family":"Bor","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Belgy\u00f3gy\u00e1szati Klinika Szeged Kor\u00e1nyi fasor 8\u201310. 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaudia","family":"Farkas","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. 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