{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T07:56:11Z","timestamp":1648886171302},"reference-count":10,"publisher":"Akademiai Kiado Zrt.","issue":"51","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p> When multiple endocrine tumors are detected more tests are required to diagnose endocrine tumor syndromes. The authors report the case history of a patient with clinical manifestation of multiplex endocrine neoplasia type 1 (parathyroid adenoma, pancreatic neuroendocrine tumor, pituitary tumor, adrenal gland tumors and thymic neuroendocrine carcinoma). Genetic screening proved a novel stop codon mutation of the MEN1 gene in the patient and in two other members of the family. The son of the index patient showed clinical symptoms of pancreatic neuroendocrine tumor (insulinoma) and parathyroid adenoma. One of the two daughters was also positive for the same mutation, however, she had no clinical symptoms. The authors review current knowledge on the genetic background of multiple endocrine syndrome type 1, the role of menin and the usefulness of gene mutation screening. Orv. Hetil., 2013, 154(51), 2037\u20132042. <\/jats:p>","DOI":"10.1556\/oh.2013.29772","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T02:00:48Z","timestamp":1387159248000},"page":"2037-2042","source":"Crossref","is-referenced-by-count":0,"title":["Various neuroendocrine tumors in a multiple endocrine neoplasia type 1 family"],"prefix":"10.1556","volume":"154","author":[{"given":"Kriszti\u00e1n","family":"Sepp","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Belgy\u00f3gy\u00e1szati Klinika Szeged Kor\u00e1nyi fasor 8\u201310. 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Valkusz","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Belgy\u00f3gy\u00e1szati Klinika Szeged Kor\u00e1nyi fasor 8\u201310. 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","volume-title":"Practical handbook of endocrinology and metabolic disorders. [Az endokrin \u00e9s anyagcsere-betegs\u00e9gek gyakorlati k\u00e9zik\u00f6nyve.]","year":"2011"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/ajco.12046","volume":"9","year":"2013","journal-title":"Asia Pac. J. Clin. Oncol."},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/humu.20605","volume":"29","year":"2008","journal-title":"Hum. Mutat."},{"key":"atypb4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1053\/j.seminoncol.2012.11.005","volume":"40","year":"2013","journal-title":"Semin. Oncol."},{"key":"atypb5","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1210\/jc.2012-1230","volume":"97","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"atypb6","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1111\/j.1349-7006.2011.02055.x","volume":"102","year":"2011","journal-title":"Cancer Sci."},{"key":"atypb7","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1507\/endocrj.EJ12-0145","volume":"59","year":"2012","journal-title":"Endocr. J."},{"key":"atypb8","doi-asserted-by":"crossref","first-page":"E282","DOI":"10.1210\/jc.2011-0241","volume":"97","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tibs.2013.05.005","volume":"38","year":"2013","journal-title":"Trends Biochem. Sci."},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4158\/EP10379.RA","volume":"17","year":"2011","journal-title":"Endocr. Pract."}],"container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/OH.2013.29772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:54:26Z","timestamp":1590141266000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/oh.2013.29772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":10,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1556\/OH.2013.29772"],"URL":"https:\/\/doi.org\/10.1556\/oh.2013.29772","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]}}}