{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T20:06:21Z","timestamp":1648929981820},"reference-count":44,"publisher":"Akademiai Kiado Zrt.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p> Anorexia nervosa is a serious, chronical state of illness which often starts in childhood or adolescence and has serious consequences on the quality of life. This review focuses on the heterogenity of the disease with emphasis on special diagnostic implications in case of childhood onset. Research findings of the last decade showed that genetic and neurobiological vulnerabilities are at least as potent risk factors as psychological, family constellations and sociocultural preferences. The heritability of eating disorders levels those of diseases predominantly influenced by biological factors. The authors give a summary of the most investigated neurobiologic and neurocognitive factors which could be the fundaments of a biological vulnerablilty. To date, no common risk factor could be identified, but some existing adversities can clearly be related to distinct subgroups with the disorder. The concept of endo- and subphenotypes leads to more specific and more efficiant methods of therapy in other somatic and psychiatric diseases. Orv. Hetil., 2014, 155(4), 124\u2013131. <\/jats:p>","DOI":"10.1556\/oh.2014.29812","type":"journal-article","created":{"date-parts":[[2014,1,19]],"date-time":"2014-01-19T02:01:57Z","timestamp":1390096917000},"page":"124-131","source":"Crossref","is-referenced-by-count":0,"title":["The challenging heterogenity of anorexia nervosa. Neurobiological risk factors and possible endophenotypes"],"prefix":"10.1556","volume":"155","author":[{"given":"Bea","family":"P\u00e1szthy","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Gyermekgy\u00f3gy\u00e1szati Klinika, Gyermek- \u00e9s Ifj\u00fas\u00e1gpszichi\u00e1triai Oszt\u00e1ly Budapest B\u00f3kay J. u. 53. 1086"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ria","family":"T\u00f6rzs\u00f6k-Sonnevend","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Gyermekgy\u00f3gy\u00e1szati Klinika, Gyermek- \u00e9s Ifj\u00fas\u00e1gpszichi\u00e1triai Oszt\u00e1ly Budapest B\u00f3kay J. u. 53. 1086"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1556\/OH.2007.27945","volume":"148","year":"2007","journal-title":"Orv. 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