{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:13:23Z","timestamp":1785464003768,"version":"3.56.0"},"reference-count":32,"publisher":"Akademiai Kiado Zrt.","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>Cardiac complications may present a particular problem following radiation treatment applied to the mediastinum and thoracic wall (and especially to the left breast). Exposure of the heart during radiotherapy increases the risk of ischemic heart disease occurring generally years after the treatment. The incidence of radiation cardiotoxicity depends on various factors related to oncological therapies and the patient (details of radiotherapy, age, gender, comorbidies, smoking habits, etc.). Until recently the majority of clinical studies reported increased cardiac morbidity in patients receiving radiation treatment of the chest wall and the breast. Due to modern methods, however, postoperative chest wall and left breast irradiation is much safer today than previously. In order to avoid cardiotoxity, adherance to clinical practice guidelines for chemo- and targeted therapy of breast cancer, use of the most advanced irradiation procedures, regular monitoring of patients, and close cooperation between cardiologists and ocologists are all recommended. Orv. Hetil., 2014, 155(23), 897\u2013902.<\/jats:p>","DOI":"10.1556\/oh.2014.29890","type":"journal-article","created":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T01:00:55Z","timestamp":1401584455000},"page":"897-902","source":"Crossref","is-referenced-by-count":3,"title":["Postoperative radiotherapy of breast cancer and cardiotoxicity"],"prefix":"10.1556","volume":"155","author":[{"given":"Tam\u00e1s","family":"Nagyk\u00e1lnai","sequence":"first","affiliation":[{"name":"XV. ker\u00fcleti Szakrendel\u0151 Onkol\u00f3gia Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Csaba","family":"Nagy","sequence":"additional","affiliation":[{"name":"Uzsoki utcai K\u00f3rh\u00e1z I. Belgy\u00f3gy\u00e1szat Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Landherr","sequence":"additional","affiliation":[{"name":"Uzsoki utcai K\u00f3rh\u00e1z Onkoradiol\u00f3giai K\u00f6zpont Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"1","unstructured":"<i>Steele, G. G.:<\/i> Basic clinical radiobiology. Arnold Press, London, 1997."},{"key":"2","doi-asserted-by":"crossref","unstructured":"<i>Byrd, B. F. 3rd, Mendes, L. A.:<\/i> Cardiac complications of mediastinal radiotherapy. The other side of the coin. J. Am. Coll. Cardiol., 2003, <i>42<\/i>(4), 750\u2013751.","DOI":"10.1016\/S0735-1097(03)00760-5"},{"key":"3","doi-asserted-by":"crossref","unstructured":"<i>Paszat, L. F., Mackillop, W. J., Groome, P. A., et al.:<\/i> Mortality from myocardial infarction after adjuvant radiotherapy for breast cancer in the surveillance, epidemiology, and end-results cancer registries. J. Clin. Oncol., 1998, <i>16<\/i>(8), 2625\u20132631.","DOI":"10.1200\/JCO.1998.16.8.2625"},{"key":"4","doi-asserted-by":"crossref","unstructured":"<i>Gaya, A. M., Ashford, R. F. U.:<\/i> Cardiac complications of radiation therapy. Clin. Oncol. (R. Coll. Radiol.), 2005, <i>17<\/i>(3), 153\u2013159.","DOI":"10.1016\/j.clon.2004.09.016"},{"key":"5","doi-asserted-by":"crossref","unstructured":"<i>Bovelli, D., Plataniotis, G., Roila, F., et al.:<\/i> Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO Clinical Practice Guidelines. Ann. Oncol., 2010, <i>21<\/i>(Suppl. 5), v277\u2013v282.","DOI":"10.1093\/annonc\/mdq200"},{"key":"6","doi-asserted-by":"crossref","unstructured":"<i>Constine, L. S., Schwartz, R. G., Savage, D. E., et al.:<\/i> Cardiac function, perfusion, and morbidity in irradiated long-term survivors of Hodgkin-disease. Int. J. Radiat. Oncol. Biol. Phys., 1997, <i>39<\/i>(4), 897\u2013906.","DOI":"10.1016\/S0360-3016(97)00467-7"},{"key":"7","doi-asserted-by":"crossref","unstructured":"<i>Hancock, S. L., Tucker, M. A., Hoppe, R. T.:<\/i> Factors affecting late mortality from heart disease after treatment of Hodgkin\u2019s disease. JAMA, 1993, <i>270<\/i>(16), 1949\u20131955.","DOI":"10.1001\/jama.270.16.1949"},{"key":"8","doi-asserted-by":"crossref","unstructured":"<i>Early Breast Cancer Trialists\u2019 Collaborative Gruop:<\/i> Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet, 2000, <i>355<\/i>(9217), 1757\u20131770.","DOI":"10.1016\/S0140-6736(00)02263-7"},{"key":"9","doi-asserted-by":"crossref","unstructured":"<i>Cuzick, J., Stewart, H., Rutqvist, L., et al.:<\/i> Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy [see comment]. J. Clin. Oncol., 1994, <i>12<\/i>(3), 447\u2013453.","DOI":"10.1200\/JCO.1994.12.3.447"},{"key":"10","doi-asserted-by":"crossref","unstructured":"<i>Clarke, M., Collins, R., Darby, S., et al.:<\/i> Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival. An overview of the randomised trials. Lancet, 2005, <i>366<\/i>(9503), 2087\u20132106.","DOI":"10.1016\/S0140-6736(05)67887-7"},{"key":"11","unstructured":"<i>Kah\u00e1n, Zs.:<\/i> Radiotherapy. In: Bodoky, Gy., Kopper, L. (eds.): Breast- and gynecologic oncology. [Sug\u00e1rkezel\u00e9s. In: Bodoky, Gy., Kopper, L. (szerk.): Eml\u0151- \u00e9s n\u0151gy\u00f3gy\u00e1szati onkol\u00f3gia.] Medicina K\u00f6nyvkiad\u00f3, Budapest, 2012. [Hungarian]"},{"key":"12","doi-asserted-by":"crossref","unstructured":"<i>Harris, E. E., Correa, C., Hwang, W. T., et al.:<\/i> Late cardiac mortality and morbidity in early-stage breast cancer patients after breast conservation treatment. J. Clin. Oncol., 2006, <i>24<\/i>(25), 4100\u20134106.","DOI":"10.1200\/JCO.2005.05.1037"},{"key":"13","unstructured":"National Heart, Lung and Blood Institute: Risk assessment tool for estimating vour 10-year risk of having a heart attack. <a href=\"http:\/\/cvdrisk.nhlbi.nih.gov\/calculator.asp\">http:\/\/cvdrisk.nhlbi.nih.gov\/calculator.asp<\/a>"},{"key":"14","doi-asserted-by":"crossref","unstructured":"<i>Heidenreich, P. A., Hancock, S. L., Lee, B. K., et al.:<\/i> Asymptomatic cardiac disease following mediastinal irradiation. J. Am. Coll. Cardiol., 2003, <i>42<\/i>(4), 743\u2013749.","DOI":"10.1016\/S0735-1097(03)00759-9"},{"key":"15","doi-asserted-by":"crossref","unstructured":"<i>Giordano, S. H., Kuo, Y. F., Freeman, J. L., et al.:<\/i> Risk of cardiac death after adjuvant radiotherapy for breast cancer. J. Natl. Cancer Inst., 2005, <i>97<\/i>(6), 419\u2013424.","DOI":"10.1093\/jnci\/dji067"},{"key":"16","doi-asserted-by":"crossref","unstructured":"<i>Patt, D. A., Goodwin, J. S., Kuo, Y. F., et al.:<\/i> Cardiac morbidity of adjuvant radiotherapy for breast cancer. J. Clin. Oncol., 2005, <i>23<\/i>(30), 7475\u20137482.","DOI":"10.1200\/JCO.2005.13.755"},{"key":"17","doi-asserted-by":"crossref","unstructured":"<i>Henson, K. E., McGale, P., Taylor, C., et al.:<\/i> Radiation-related mortality from heart disease and lung cancer more than 20 years after radiotherapy for breast cancer. Br. J. Cancer, 2013, <i>108<\/i>(1), 179\u2013182.","DOI":"10.1038\/bjc.2012.575"},{"key":"18","doi-asserted-by":"crossref","unstructured":"<i>McGale, P., Darby, S. C., Hall, P., et al.:<\/i> Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden. Radiother. Oncol., 2011, <i>100<\/i>(2), 167\u2013175.","DOI":"10.1016\/j.radonc.2011.06.016"},{"key":"19","doi-asserted-by":"crossref","unstructured":"<i>Darby, S. C., Ewertz, M., McGale, P., et al.:<\/i> Risk of ischemic heart disease in women after radiotherapy for breast cancer. N. Engl. J. Med., 2013, <i>368<\/i>(11), 987\u2013998.","DOI":"10.1056\/NEJMoa1209825"},{"key":"20","doi-asserted-by":"crossref","unstructured":"<i>Boekel, N. B., Schaapveld, M., Gietema, J. A., et al.:<\/i> Cardiovascular morbidity and mortality in patients treated for ductal carcinoma in situ of the breast. Breast Cancer Symposium, 2013. San Francisco, CA, Abstract 58.","DOI":"10.1200\/jco.2013.31.26_suppl.58"},{"key":"21","doi-asserted-by":"crossref","unstructured":"<i>Nixon, A. J., Manola, J., Gelman, R., et al.:<\/i> No long-term increase in cardiac related mortality after breast-conserving surgery and radiation therapy using modern techniques. J. Clin. Oncol., 1998, <i>16<\/i>(4), 1374\u20131379.","DOI":"10.1200\/JCO.1998.16.4.1374"},{"key":"22","doi-asserted-by":"crossref","unstructured":"<i>Remouchamps, V. M., Vicini, F. A., Sharpe, M. B., et al.:<\/i> Significant reductions in heart and lung doses using deep inspiration breath hold with active breathing control and intensity-modulated radiation therapy for patients treated with locoregional breast irradiation. Int. J. Radiat. Oncol. Biol. Phys., 2003, <i>55<\/i>(2), 392\u2013406.","DOI":"10.1016\/S0360-3016(02)04143-3"},{"key":"23","unstructured":"<i>Polg\u00e1r, C., Major, T., Somogyi, A., et al.:<\/i> Sole brachytherapy of the tumor bed after breast conserving surgery: a new radiotherapeutic strategy for patients at low-risk of local relapse. Neoplasma, 1999, <i>46<\/i>(3), 182\u2013189."},{"key":"24","doi-asserted-by":"crossref","unstructured":"<i>Vu, K. N., Dragun, A. E., Cole, D. J., et al.:<\/i> Accelerated partial breast irradiation using the MammoSite breast brachytherapy technique: a multidisciplinary approach to breast-conservation therapy. Commun. Oncol., 2005, <i>2<\/i>(6), 477\u2013490.","DOI":"10.1016\/S1548-5315(11)70628-3"},{"key":"25","unstructured":"<i>Fodor, J.:<\/i> Evidence-based radiotherapy in the treatment of early-stage invasive breast cancer: traditional risk factors and biomarkers. [Evidenci\u00e1k a korai invaz\u00edv eml\u0151r\u00e1k sug\u00e1rkezel\u00e9s\u00e9ben: hagyom\u00e1nyos klinikai jellemz\u0151k \u00e9s biomarkerek.] Magy. Onkol., 2009, <i>53<\/i>(1), 7\u201314. [Hungarian]"},{"key":"26","doi-asserted-by":"crossref","unstructured":"<i>Recht, A.:<\/i> Which breast cancer patients should <i>really<\/i> worry about radiation-induced heart disease \u2013 and how much? J. Clin. Oncol., 2006, <i>24<\/i>(25), 4059\u20134061.","DOI":"10.1200\/JCO.2006.07.7909"},{"key":"27","doi-asserted-by":"crossref","unstructured":"<i>Lonardi, F., Gioga, G., Coeli, M., et al.:<\/i> Heart exposure in 100 consecutive, unselected patients treated with adjuvant 3D conformal radiotherapy for left-sided breast cancer. Breast Cancer Symposium, 2013. San Francisco, CA, Abstract 103.","DOI":"10.1200\/jco.2013.31.26_suppl.103"},{"key":"28","doi-asserted-by":"crossref","unstructured":"<i>Jacobson, G. M., Wen, S., Zhang, J., et al.:<\/i> Mean radiation dose to the heart in patients with breast cancer. Breast Cancer Symposium, 2013. San Francisco, CA, Abstract 56.","DOI":"10.1200\/jco.2013.31.26_suppl.56"},{"key":"29","doi-asserted-by":"crossref","unstructured":"<i>Erven, K., Florian, A., Slagmolen, P., et al.:<\/i> Subclinical cardiotoxicity detected by strain rate imaging up to 14 months after breast radiation therapy. Int. J. Radiat. Oncol. Biol. Phys., 2013, <i>85<\/i>(5), 1172\u20131178.","DOI":"10.1016\/j.ijrobp.2012.09.022"},{"key":"30","doi-asserted-by":"crossref","unstructured":"<i>Chung, E., Corbett, J. R., Moran, J. M., et al.:<\/i> Is there a dose-response relationship for heart disease with low-dose radiation therapy? Int. J. Radiat. Oncol. Biol. Phys., 2013, <i>85<\/i>(4), 959\u2013964.","DOI":"10.1016\/j.ijrobp.2012.08.002"},{"key":"31","unstructured":"<i>Helwick, C.:<\/i> Breast cancer radiotherapy and cardiotoxicity: what is the true risk? The ASCO Post, 2013, <i>4,<\/i>(16)."},{"key":"32","doi-asserted-by":"crossref","unstructured":"<i>Early Breast Cancer Trialists\u2019 Collaborative Group:<\/i> Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10 801 women in 17 randomised trials. Lancet, 2011, <i>378<\/i>(9804), 1707\u20131716.","DOI":"10.1016\/S0140-6736(11)61629-2"}],"container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/OH.2014.29890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:55:29Z","timestamp":1590141329000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/oh.2014.29890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":32,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1556\/OH.2014.29890"],"URL":"https:\/\/doi.org\/10.1556\/oh.2014.29890","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}