{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:58:42Z","timestamp":1789340322695,"version":"build-2803163510"},"reference-count":37,"publisher":"Akademiai Kiado Zrt.","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Ectopic pregnancy is a high-risk condition that occurs in 2% of reported pregnancies. This percentage is fivefold higher than that registered in the 1970s. Since 1970 there has been a two-fold increase in the ratio of ectopic pregnancies to all reported pregnancies in Hungary and in 2012 7.4 ectopic pregnancies per thousand registered pregnancies were reported. Recently, the majority (80%) of cases can be diagnosed in early stage, and the related mortality objectively decreased in the past few decades to 3.8\/10,000 ectopic pregnancies. If a woman with positive pregnancy test has abdominal pain and\/or vaginal bleeding the physician should perform a work-up to safely exclude the possibility of ectopic pregnancy. The basis of diagnosis is ultrasonography, especially vaginal ultrasound examination and measurement of the \u03b2-subunit of human chorionic gonadotropin. The ultrasound diagnosis is based on the visualization of an ectopic mass rather than the inability to visualize an intrauterine pregnancy. In some questionable cases the diagnostic uterine curettage or laparoscopy may be useful. The actuality of this topic is justified by practical difficulties in obtaining correct diagnosis, especially in the early gestational time. Orv. Hetil., 2014, 155(29), 1158\u20131166.<\/jats:p>","DOI":"10.1556\/oh.2014.29933","type":"journal-article","created":{"date-parts":[[2014,7,13]],"date-time":"2014-07-13T01:01:02Z","timestamp":1405213262000},"page":"1158-1166","source":"Crossref","is-referenced-by-count":17,"title":["Early diagnosis of ectopic pregnancy"],"prefix":"10.1556","volume":"155","author":[{"given":"Zoran","family":"Belics","sequence":"first","affiliation":[{"name":"Jahn Ferenc D\u00e9l-pesti K\u00f3rh\u00e1z \u00e9s Rendel\u0151int\u00e9zet Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest K\u00f6ves u. 1. 1204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"G\u00e9recz","sequence":"additional","affiliation":[{"name":"Jahn Ferenc D\u00e9l-pesti K\u00f3rh\u00e1z \u00e9s Rendel\u0151int\u00e9zet Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest K\u00f6ves u. 1. 1204"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Gy\u00f6rgy","family":"Cs\u00e1k\u00e1ny","sequence":"additional","affiliation":[{"name":"Jahn Ferenc D\u00e9l-pesti K\u00f3rh\u00e1z \u00e9s Rendel\u0151int\u00e9zet Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly Budapest K\u00f6ves u. 1. 1204"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"<i>Honemeyer, U., Alkatout, I., Kupesic-Plavsic, S., et al.:<\/i> The value of color and power Doppler in the diagnosis of ectopic pregnancy. Donald School J. Ultrasound Obstet. Gynecol., 2013, <i>7<\/i>(4), 429\u2013439.","DOI":"10.5005\/jp-journals-10009-1314"},{"key":"2","doi-asserted-by":"crossref","unstructured":"<i>Creanga, A. A., Shapiro-Mendoza, C. K., Bish, C. L., et al.:<\/i> Trends in ectopic pregnancy mortality in the United States: 1980\u20132007. Obstet. Gynecol., 2011, <i>117<\/i>(4), 837\u2013843.","DOI":"10.1097\/AOG.0b013e3182113c10"},{"key":"3","unstructured":"<i>Gervaise, A., Masson, L., de Tayrac, R., et al.:<\/i> Reproductive outcome after methotrexate treatment of tubal pregnancies. Fertil. Steril. 2004, <i>82<\/i>(2), 304\u2013308."},{"key":"4","unstructured":"<i>Lozeau, A. M., Potter, B.:<\/i> Diagnosis and management of ectopic pregnancy. Am. Fam. Physician, 2005, <i>72<\/i>(9), 1707\u20131714."},{"key":"5","unstructured":"<i>Goldner, T. E., Lawson, H. W., Xia, Z., et al.:<\/i> Surveillance for ectopic pregnancy \u2013 United States, 1970\u20131989. MMWR CDC Surveill. Summ., 1993, <i>42<\/i>(6), 73\u201385."},{"key":"6","doi-asserted-by":"crossref","unstructured":"<i>Jurkovic, D., Wilkinson, H.:<\/i> Diagnosis and management of ectopic pregnancy. BMJ, 2011, <i>342,<\/i> d3397.","DOI":"10.1136\/bmj.d3397"},{"key":"7","doi-asserted-by":"crossref","unstructured":"<i>Kirk, E., Bottomley, C., Bourne, T.:<\/i> Diagnosing ectopic pregnancy and current concepts in the management of pregnancy of unknown location. Hum. Reprod. Update, 2014, <i>20<\/i>(2), 250\u2013261.","DOI":"10.1093\/humupd\/dmt047"},{"key":"8","doi-asserted-by":"crossref","unstructured":"<i>Cagnacci, A., Landi, S., Volpe, A.:<\/i> Rhythmic variation in the rate of ectopic pregnancy throughout the year. Am. J. Obstet. Gynecol., 1999, <i>180<\/i>(5), 1067\u20131071.","DOI":"10.1016\/S0002-9378(99)70596-X"},{"key":"9","unstructured":"<i>Papp, Z.<\/i> (ed.): Textbook of obstetrics and gynecology. 3rd edition. [A sz\u00fcl\u00e9szet-n\u0151gy\u00f3gy\u00e1szat tank\u00f6nyve. 3. kiad\u00e1s.] Semmelweis Kiad\u00f3, Budapest, 2007. [Hungarian]"},{"key":"10","doi-asserted-by":"crossref","unstructured":"<i>Sziller, I., Babula, O., Ujh\u00e1zy, A., et al.:<\/i> Chlamydia trachomatis infection. Fallopian tube damage and a mannose-binding lectin codon 54 gene polymorphism. Hum. Reprod., 2007, <i>22<\/i>(7), 1861\u20131865.","DOI":"10.1093\/humrep\/dem107"},{"key":"11","unstructured":"<i>Speroff, L., Glass, R. H., Kase, N. G.:<\/i> Clinical gynecologic endocrinology and infertility. 6th edition. Lippincott Williams & Wilkins, Philadelphia, 1999."},{"key":"12","unstructured":"<i>Hietala, S. O., Andersson, M., Emdin, S. O.:<\/i> Ectopic pregnancy in the liver. Report of a case and angiographic findings. Acta Chir. Scand., 1983, <i>149<\/i>(6), 633\u2013635."},{"key":"13","doi-asserted-by":"crossref","unstructured":"<i>Lau, S., Tulandi, T.:<\/i> Conservative medical and surgical management of interstitial ectopic pregnancy. Fertil. 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Medical management of tubal pregnancy. Number 3, December 1998. Clinical management guidelines for obstetrician-gynecologists. American College of Obstetricians and Gynecologists. Int. J. Gynaecol. Obstet., 1999, <i>65<\/i>(1), 97\u2013103."},{"key":"18","doi-asserted-by":"crossref","unstructured":"Clinical policy: Critical issues in the initial evaluation and management of patients presenting to the emergency department in early pregnancy. ACEP Clinical Policies Committee and the Clinical Policies Subcommittee on Early Pregnancy. Ann. Emerg. Med., 2003, <i>41<\/i>(1), 123\u2013133.","DOI":"10.1067\/mem.2003.13"},{"key":"19","unstructured":"<i>B\u00f3dis, J.:<\/i> Ectopic pregnancy. In: P\u00e1l, A. (ed.): University textbook of obstetrics and gynecology. [M\u00e9hen k\u00edv\u00fcli terhess\u00e9g. In: P\u00e1l, A. (szerk.): A sz\u00fcl\u00e9szet-n\u0151gy\u00f3gy\u00e1szat egyetemi tank\u00f6nyve.] Medicina K\u00f6nyvkiad\u00f3, Budapest, 2012. 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C.:<\/i> Demonstration of ectopic pregnancy by transvaginal ultrasound. Br. J. Obstet. Gynaecol., 1988, <i>95<\/i>(12), 1253\u20131256.","DOI":"10.1111\/j.1471-0528.1988.tb06814.x"},{"key":"27","unstructured":"<i>Hern\u00e1di, L.:<\/i> Early diagnosis and treatment of ectopic pregnancy. In: T\u00f3th, Z., Papp, Z. (eds.): Ultrasound in obstetrics and gynecology. [A m\u00e9hen k\u00edv\u00fcli terhess\u00e9g diagnosztik\u00e1ja \u00e9s kezel\u00e9se. In: T\u00f3th, Z., Papp, Z. (szerk.): Sz\u00fcl\u00e9szet-n\u0151gy\u00f3gy\u00e1szati ultrahang-diagnosztika.] White Golden Book Kft., Budapest, 2006. [Hungarian]"},{"key":"28","doi-asserted-by":"crossref","unstructured":"<i>Kirk, E., Daemen, A., Papageorghiou, A. T., et al.:<\/i> Why are some ectopic pregnancies characterized as pregnancies of unknown location at the initial transvaginal ultrasound examination? Acta Obstet. Gynecol. 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Steril., 1995, <i>63<\/i>(1), 15\u201319.","DOI":"10.1016\/S0015-0282(16)57289-6"}],"container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/OH.2014.29933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:55:45Z","timestamp":1590141345000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/oh.2014.29933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":37,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1556\/OH.2014.29933"],"URL":"https:\/\/doi.org\/10.1556\/oh.2014.29933","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}