{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:18:40Z","timestamp":1740147520795,"version":"3.37.3"},"reference-count":32,"publisher":"Akademiai Kiado Zrt.","issue":"27","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Introduction: MicroRNAs play a role in carcinogenesis through their genome regulatory function. Aim: The aim of the authors was to identify and compare microRNA expression signatures of meso- and hypopharynx squamous cell cancers on the basis of the cancer field hypothesis. Method: Using standard mapping biopsy (tumour tissue and macroscopically normal tissues obtained 1, 2 and 3 cm from margin) 13 snap frozen sample series were analysed for microRNA expression with quantitative real-time polymerase chain reaction. Results: MiR-221 was significantly overexpressed in mesopharynx cancers, whole miR-21, miR-143 and miR-155 showed significant overexpression in hypopharynx cancers. Conclusions: Using microRNA expression profiles the authors were able to distinguish peritumoural tissues according to distance from the primary tumour site. Future application of the method may prove to be useful in early detection of the altered epigenetic regulation in tissue fields representing normal phenotype. This may be helpful in cancer risk assessment and prevention. Orv. Hetil., 2014, 155(27), 1063\u20131070.<\/jats:p>","DOI":"10.1556\/oh.2014.29945","type":"journal-article","created":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T01:04:23Z","timestamp":1404090263000},"page":"1063-1070","source":"Crossref","is-referenced-by-count":0,"title":["MicroRNA expression profiles in squamous cell carcinomas of the meso- and hypopharynx"],"prefix":"10.1556","volume":"155","author":[{"given":"\u00c9va","family":"Orosz","sequence":"first","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar F\u00fcl-Orr-G\u00e9g\u00e9szeti \u00e9s Fej-Nyakseb\u00e9szeti Klinika, Klinikai K\u00f6zpont P\u00e9cs Munk\u00e1csy M. u. 2. 7621"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Gombos","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Orvosi N\u00e9peg\u00e9szs\u00e9gtani Int\u00e9zet P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"R\u00e9v\u00e9sz","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar F\u00fcl-Orr-G\u00e9g\u00e9szeti \u00e9s Fej-Nyakseb\u00e9szeti Klinika, Klinikai K\u00f6zpont P\u00e9cs Munk\u00e1csy M. u. 2. 7621"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Kiss","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Orvosi N\u00e9peg\u00e9szs\u00e9gtani Int\u00e9zet P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Pytel","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar F\u00fcl-Orr-G\u00e9g\u00e9szeti \u00e9s Fej-Nyakseb\u00e9szeti Klinika, Klinikai K\u00f6zpont P\u00e9cs Munk\u00e1csy M. u. 2. 7621"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imre","family":"Gerlinger","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar F\u00fcl-Orr-G\u00e9g\u00e9szeti \u00e9s Fej-Nyakseb\u00e9szeti Klinika, Klinikai K\u00f6zpont P\u00e9cs Munk\u00e1csy M. u. 2. 7621"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Szanyi","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar F\u00fcl-Orr-G\u00e9g\u00e9szeti \u00e9s Fej-Nyakseb\u00e9szeti Klinika, Klinikai K\u00f6zpont P\u00e9cs Munk\u00e1csy M. u. 2. 7621"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"unstructured":"Ember, I., Kiss, I., Cseh, K.:<\/i> Public health medicine. 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