{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T17:18:13Z","timestamp":1776187093095,"version":"3.50.1"},"reference-count":36,"publisher":"Akademiai Kiado Zrt.","issue":"36","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Introduction: Assessment of the impact of pneumococcal conjugate vaccines on the burden of pneumonia, meningitis, and septicemia in Hungary is limited. Aim: The aim of this retrospective study was to quantify rates of hospitalized multi-cause and pneumococcal pneumonia, meningitis, and septicemia in all age groups in Hungary between 2006 and 2011. Method: Aggregate data were obtained from the Hungarian National Healthcare Fund using pre-specified ICD-10 codes. Comparisons included average rates pre-vaccine (2006\u20132007) versus post-vaccine (2010\u20132011) using a \u03c72<\/jats:sup>test. Results: Hospitalization rates among children aged 0\u20134 years significantly declined for multi-cause pneumonia and meningitis, but increased for septicemia. There were significant increases in multi-cause pneumonia and septicemia in other age groups. In-hospital mortality rates increased with age. Limited use of pneumococcal-specific codes led to inconclusive findings for pneumococcal diseases. Conclusions: Declines in multi-cause pneumonia and meningitis in children aged 0\u20134 years suggest direct effects of pneumococcal conjugate vaccination on hospitalization rates. Orv. Hetil., 2014, 155(36), 1426\u20131436.<\/jats:p>","DOI":"10.1556\/oh.2014.29990","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T01:01:04Z","timestamp":1409533264000},"page":"1426-1436","source":"Crossref","is-referenced-by-count":4,"title":["Clinical burden of multi-cause and pneumococcal pneumonia, meningitis, and septicemia in Hungary. Results of a retrospective study (2006\u20132011)"],"prefix":"10.1556","volume":"155","author":[{"given":"Endre","family":"Ludwig","sequence":"first","affiliation":[{"name":"Semmelweis Egyetem II. Belgy\u00f3gy\u00e1szati Klinika, Infektol\u00f3giai Tansz\u00e9ki Csoport Budapest Gy\u00e1li \u00fat 5\u20137. 1097"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Via Research Princeton Junction NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Gray","sequence":"additional","affiliation":[{"name":"Pfizer, Inc. Collegeville PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Munson","sequence":"additional","affiliation":[{"name":"Pfizer, Inc. Collegeville PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Chou","sequence":"additional","affiliation":[{"name":"Via Research Princeton Junction NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elane M.","family":"Gutterman","sequence":"additional","affiliation":[{"name":"Via Research Princeton Junction NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","unstructured":"World Health Organization:<\/i> Streptococcus pneumoniae (Pneumococcus). http:\/\/www.who.int\/nuvi\/pneumococcus\/en\/<\/a>"},{"key":"2","unstructured":"World Health Organization:<\/i> Pneumococcal vaccines. Wkly Epidemiol. Rec., 2000, 78,<\/i> 110\u2013119."},{"key":"3","doi-asserted-by":"crossref","unstructured":"Lynch, J. P. 3rd, Zhanel, G. G.:<\/i> Streptococcus pneumoniae: epidemiology, risk factors, and strategies for prevention. Semin. Respir. Crit. 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Dis., 2010, 14<\/i>(3), e197\u2013e209.","DOI":"10.1016\/j.ijid.2009.05.010"},{"key":"6","unstructured":"Iv\u00e1dy, B., Liptai, Z., Ujhelyi, E., et al.:<\/i> Pneumococcal meningitis in children \u2013 9 1\/2-year-experience at Szent Laszlo Hospital, Budapest, Hungary. [Pneumococcus-meningitis gyermekkorban \u2013 kilenc \u00e9s f\u00e9l \u00e9v tapasztalata a Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1zban.] Ideggyogy. Sz., 2008, 61<\/i>(11\u201312), 385\u2013390. [Hungarian]"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Prymula, R., Chlibek, R., Ivaskeviciene, I., et al.:<\/i> Paediatric pneumococcal disease in Central Europe. Eur. J. Clin. Microbiol. Infect. Dis., 2011, 30<\/i>(11), 1311\u20131320.","DOI":"10.1007\/s10096-011-1241-y"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Pebody, R. G., Hellenbrand, W., D\u2019Ancona, F., et al.:<\/i> Pneumococcal disease surveillance in Europe. 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