{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T10:58:38Z","timestamp":1648810718210},"reference-count":15,"publisher":"Akademiai Kiado Zrt.","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Introduction: Nearly 6000 autoptic studies were carried out during the last 50 years at the Laboratory of Neuropathology, Markusovszky University Teaching Hospital, Hungary, Aim: The aim of the authors was to present those previously frequent and often fatal conditions that can be prevented or treated today. Method: Retrospective analyses of the neuropathological documentations. Results: Measles-related subacute sclerosing panencephalitis caused death in 13 cases, the last occurred in 1991. The mandatory vaccination against the causative virus has eliminated this severe neurological complication. Fourteen lives were lost due to herpes simplex encephalitis, including the last case seen in 1999. Feasibility of early diagnosis and the availability of acyclovir therapy resulted in better outcome without fatality. Tuberculous meningitis still occurred in most recent years, although only sporadically. Recognition of this condition is not straightforward due to its rarity, and considerations for this disease are often omitted from the routine differential diagnosis. The generally low mortality rates in tick borne encephalitis further dropped after the introduction of vaccination. Altogether only 8 such cases were documented. The last fatal cases of neurolues were seen in the 1990s. However, syphilis itself has not disappeared, and the number of cases with newly acquired infection continues to rise. The introduction of intrathecal methotrexate and radiotherapy made possible the prevention or effective treatment of meningeal leukosis. A careful coordination of these treatment modalities, however, is important as nervous system complications may develop in the form of disseminated necrotizing leukoencephalopathy that is also reflected in the records. Conclusions: The 50-year neuropathology documentation reflects changes in the occurrence of diseases, and it calls attention to those disorders which can be prevented or treated today, but may represent diagnostic challenges. Orv. Hetil., 2014, 155(43), 1722\u20131728.<\/jats:p>","DOI":"10.1556\/oh.2014.29996","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T01:01:16Z","timestamp":1413766876000},"page":"1722-1728","source":"Crossref","is-referenced-by-count":0,"title":["Changing times \u2013 changing diseases. Review of the neuropathological autopsy documentations at the Markusovszky University Teaching Hospital (1964\u20132014)"],"prefix":"10.1556","volume":"155","author":[{"given":"Ferenc","family":"Garzuly","sequence":"first","affiliation":[{"name":"Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Patol\u00f3giai Oszt\u00e1ly Szombathely Markusovszky u. 5. 9700"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Schneider","sequence":"additional","affiliation":[{"name":"Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Infektol\u00f3giai Oszt\u00e1ly Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos L\u00e1szl\u00f3","family":"Iv\u00e1nyi","sequence":"additional","affiliation":[{"name":"Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Haematol\u00f3giai \u00e9s Haemosztazeol\u00f3giai Oszt\u00e1ly Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Nagy","sequence":"additional","affiliation":[{"name":"Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Neurol\u00f3giai Oszt\u00e1ly Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariann","family":"Varga","sequence":"additional","affiliation":[{"name":"Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z B\u0151rgy\u00f3gy\u00e1szati Oszt\u00e1ly Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kriszti\u00e1n","family":"S\u00fct\u0151","sequence":"additional","affiliation":[{"name":"Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z K\u00f6zponti Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Betegell\u00e1t\u00f3 Oszt\u00e1ly Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Tolvaj","sequence":"additional","affiliation":[{"name":"Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Patol\u00f3giai Oszt\u00e1ly Szombathely Markusovszky u. 5. 9700"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"K\u00e1lm\u00e1n","sequence":"additional","affiliation":[{"name":"Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Kutat\u00e1si \u00e9s Oktat\u00e1si Centrum Szombathely"},{"name":"P\u00e9csi Tudom\u00e1ny Egyetem Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","unstructured":"Garzuly, F.:<\/i> Black water, turbulent times \u2013 1920\u20131956. [Fekete v\u00edz, \u00f6rv\u00e9nyl\u0151 id\u0151 \u2013 1920\u20131956.] Magyar Nyugat K\u00f6nyvkiad\u00f3, Vasszilv\u00e1gy, 2006. [Hungarian]"},{"key":"2","unstructured":"Kunt\u00e1r, L.:<\/i> Atypical panencephalitis. [Atypusos panencephalitis.] Ideggy\u00f3gy. Szle, 1991, 44<\/i>(3), 124\u2013129. [Hungarian]"},{"key":"3","unstructured":"Tariska, I.:<\/i> Neurological consequences of slow virus infections. In: Lapis, K.<\/i> (ed.): Current questions in medical virology. [A lass\u00fa v\u00edrusfert\u0151z\u00e9sek idegrendszeri k\u00f6vetkezm\u00e9nyei. In: Az orvosi virol\u00f3gia aktu\u00e1lis k\u00e9rd\u00e9sei.] Medicina K\u00f6nyvkiad\u00f3, Budapest, 1978. [Hungarian]"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Edlich, R. F., Winters, K. L., Long, W. B. 3rd., et al.:<\/i> Rubella and congenital rubella (German measles). J. Long. Term. Eff. Med. Implants, 2005, 15<\/i>(3), 319\u2013328.","DOI":"10.1615\/JLongTermEffMedImplants.v15.i3.80"},{"key":"5","unstructured":"Nyuli, L., Garzuly, F., Andits, M., et al.:<\/i> Observations regarding the clinical and pathological presentations of encephalitis associated with rubella infection. [Adatok a rubeol\u00e1hoz t\u00e1rsul\u00f3 encephalitis klinikum\u00e1hoz \u00e9s pathologi\u00e1j\u00e1hoz.] Orv. Hetil., 1981, 122<\/i>(27), 1635\u20131639. [Hungarian]"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Jagtap, S. A., Nair, M. D., Kambale, H. J.:<\/i> Subacute sclerosing panencephalitis: A clinical appraisal. Ann. Indian Acad. Neurol., 2013, 16<\/i>(4), 631\u2013633.","DOI":"10.4103\/0972-2327.120497"},{"key":"7","unstructured":"Csonka, T. S., Szepesi, R., Bidiga, L., et al.:<\/i> Diagnostics of herpes simplex encephalitis highlighted by a case discussion. [A herpesencephalitis diagnosztik\u00e1j\u00e1r\u00f3l egy esetismertet\u00e9s kapcs\u00e1n.] Ideggy\u00f3gy. Szle, 2013, 66<\/i>(9\u201310), 337\u2013342. [Hungarian]"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Gelpi, E., Preusser, M., Garzuly, F., et al.:<\/i> Visualization of Central European tick-borne encephalitis infection in fatal human cases. J. Neuropathol. Exp. Neurol., 2005, 64<\/i>(6), 506\u2013512.","DOI":"10.1093\/jnen\/64.6.506"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Gelpi, E., Preusser, M., Laggner, U., et al.:<\/i> Inflammatory response in human tick-borne encephalitis: analysis of postmortem brain tissue. J. Neurovirol., 2006, 12<\/i>(4), 322\u2013327.","DOI":"10.1080\/13550280600848746"},{"key":"10","unstructured":"Sexually transmitted infectious diseases. \u2013 Hungary, 2013, I\u2013II\u2013III. [Szexu\u00e1lis \u00faton terjed\u0151 fert\u0151z\u00e9sek \u2013 Magyarorsz\u00e1g, 2013. I\u2013II\u2013III. negyed\u00e9v. Epinfo, 2013, 20<\/i>, 301\u2013307. [Hungarian]"},{"key":"11","unstructured":"Garzuly, F., Baltav\u00e1ri, L., Ruzsa, \u00c1., et al.:<\/i> Histopathological classification of neuroleukemia. [A neuroleukaemia histopathologiai oszt\u00e1lyoz\u00e1sa.] Orvosk\u00e9pz\u00e9s, 1982, 57<\/i>(Suppl. 5), 63\u201375. [Hungarian]"},{"key":"12","unstructured":"Garzuly, F., Brittig, F., Baltav\u00e1ri, L., et al.:<\/i> Occurrence of certain subtypes of neuroleukemia in our five-year autoptic documentation. [A neuroleukaemia egyes t\u00edpusainak el\u0151fordul\u00e1sa 5 \u00e9ves secti\u00f3s anyagunkban.] Orv. Hetil., 1984, 125<\/i>(28), 1685\u20131690. [Hungarian]"},{"key":"13","unstructured":"Garzuly, F., Brittig, F., Gyenes, \u00c9., et al.:<\/i> Clinical and pathological characteristics of the disseminated necrotizing leukoencephalopathy (\u201emethotrexate encephalopathy\u201d). [A disszemin\u00e1lt nekrotiz\u00e1l\u00f3 leukoencephalopathia. (\u201eMethotrexat encephalopathia\u201d) klinikai \u00e9s patol\u00f3giai jellemz\u0151i.] Idggy\u00f3gy Szle, 1988, 41<\/i>, 173\u2013180. [Hungarian]"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Kim, J. Y., Kim, S. T., Nam, D. H., et al.:<\/i> Leukoencephalopathy and disseminated necrotizing leukoencephalopathy following intrathecal methotrexate chemotherapy and radiation therapy for central nerve system lymphoma or leukemia. J. Korean Neurosurg. Soc., 2011, 50<\/i>(4), 304\u2013310.","DOI":"10.3340\/jkns.2011.50.4.304"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Matsubayashi, J., Tsuchiya, K., Matsunaga, T., et al.:<\/i> Methotrexate-related leukoencephalopathy without radiation therapy: distribution of brain lesions and pathological heterogeneity on two autopsy cases. 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