{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:11:25Z","timestamp":1769764285018,"version":"3.49.0"},"reference-count":34,"publisher":"Akademiai Kiado Zrt.","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Chronic pancreatitis is an inflammatory disease associated with structural and functional damage of the pancreas. In most cases pain, maldigestion and weight loss are the leading sympthoms, which significantly worsen the quality of life. Correct diagnosis and differential diagnosis of chronic pancreatitis and treatment of these patients requires up-to-date and evidence based treatment guidelines. The Hungarian Pancreatic Study Group proposed to prepare an evidence based guideline based on the available international guidelines and evidence. The preparatory and consultation task force appointed by the Hungarian Pancreatic Study Group translated and complemented and\/or modified the international guidelines if it was necessary. 123 relevant clinical questions in 11 topics were defined. Evidence was classified according to the UpToDate<jats:sup>\u00ae<\/jats:sup>grading system. The draft of the guidelines were presented and discussed at the consensus meeting in September 12, 2014. All clinial questions were accepted with total or strong agreement. The present guideline is the first evidence based chronic pancreatitis guideline in Hungary. This guideline provides very important and helpful data for tuition, everyday practice and proper financing of chronic pancreatitis. Therefore, the authors believe that these guidelines will widely become a basic reference in Hungary. Orv. Hetil., 2015, 156(7), 262\u2013288.<\/jats:p>","DOI":"10.1556\/oh.2015.30060","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T02:01:21Z","timestamp":1423447281000},"page":"262-288","source":"Crossref","is-referenced-by-count":19,"title":["Chronic pancreatitis.<i>Evidence based management guidelines of the Hungarian Pancreatic Study Group<\/i>"],"prefix":"10.1556","volume":"156","author":[{"given":"Tam\u00e1s","family":"Tak\u00e1cs","sequence":"first","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont I. Belgy\u00f3gy\u00e1szati Klinika Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Czak\u00f3","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont I. Belgy\u00f3gy\u00e1szati Klinika Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Dubravcsik","sequence":"additional","affiliation":[{"name":"B\u00e1cs-Kiskun Megyei K\u00f3rh\u00e1z Gasztroenterol\u00f3gia Kecskem\u00e9t"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyula","family":"Farkas","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont Seb\u00e9szeti Klinika Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont I. Belgy\u00f3gy\u00e1szati Klinika Szeged"},{"name":"MTA\u2013SZTE Lend\u00fclet Gasztroenterol\u00f3giai Multidiszciplin\u00e1ris Kutat\u00f3csoport Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Hritz","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont I. Belgy\u00f3gy\u00e1szati Klinika Szeged"},{"name":"B\u00e1cs-Kiskun Megyei K\u00f3rh\u00e1z Gasztroenterol\u00f3gia Kecskem\u00e9t"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dezs\u0151","family":"Kelemen","sequence":"additional","affiliation":[{"name":"P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Klinikai K\u00f6zpont, Seb\u00e9szeti Klinika P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia","family":"L\u00e1sztity","sequence":"additional","affiliation":[{"name":"Heim P\u00e1l Gyermekk\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zita","family":"Morvay","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont Radiol\u00f3giai Klinika Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Ol\u00e1h","sequence":"additional","affiliation":[{"name":"Petz Alad\u00e1r Megyei Oktat\u00f3 K\u00f3rh\u00e1z Seb\u00e9szeti Oszt\u00e1ly Gy\u0151r"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1kos","family":"Pap","sequence":"additional","affiliation":[{"name":"P\u00e9terfy S\u00e1ndor utcai K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"P\u00e1rniczky","sequence":"additional","affiliation":[{"name":"Heim P\u00e1l Gyermekk\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1rp\u00e1d","family":"Patai","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar II. Belgy\u00f3gy\u00e1szati Klinika Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Sahin-T\u00f3th","sequence":"additional","affiliation":[{"name":"Boston University Henry M. Goldman School of Dental Medicine Department of Molecular and Cell Biology Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Szentkereszti","sequence":"additional","affiliation":[{"name":"Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Orvos- \u00e9s Eg\u00e9szs\u00e9gtudom\u00e1nyi Centrum Seb\u00e9szeti Klinika Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rich\u00e1rd","family":"Szmola","sequence":"additional","affiliation":[{"name":"Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet Intervenci\u00f3s Gasztroenterol\u00f3giai R\u00e9szleg Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Tiszlavicz","sequence":"additional","affiliation":[{"name":"Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont Pathologiai Int\u00e9zet Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1kos","family":"Sz\u00fccs","sequence":"additional","affiliation":[{"name":"Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar I. Seb\u00e9szeti Klinika Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"1","unstructured":"<i>Hoffmeister, A., Mayerle, J., Beglinger, C., et al.:<\/i> S3-Consensus guidelines on definition, etiology, diagnosis and medical, endoscopic and surgical management of chronic pancreatitis. Z. Gastroenterol., 2012, <i>50<\/i>(11), 1176\u20131224."},{"key":"2","doi-asserted-by":"crossref","unstructured":"<i>Hoffmeister, A., Mayerle, J., Dathe, K., et al.:<\/i> Method report to the S3 guideline chronic pancreatitis: definition, etiology, diagnostics and conservative, interventional endoscopic and surgical therapy of the chronic pancreatitis. Z. Gastroenterol., 2012, <i>50<\/i>(11), 1225\u20131236.","DOI":"10.1055\/s-0032-1325447"},{"key":"3","doi-asserted-by":"crossref","unstructured":"<i>Dufour, M. C., Adamson, M. D.:<\/i> The epidemiology of alcohol-induced pancreatitis. Pancreas, 2003, <i>27<\/i>(4), 286\u2013290.","DOI":"10.1097\/00006676-200311000-00002"},{"key":"4","doi-asserted-by":"crossref","unstructured":"<i>Mayerle, J., Hoffmeister, A., Werner, J., et al.:<\/i> Chronic pancreatitis \u2013 definition, etiology, investigation and treatment. Dtsch. Arztebl. Int., 2013, <i>110<\/i>(22), 387\u2013393.","DOI":"10.3238\/arztebl.2013.0387"},{"key":"5","doi-asserted-by":"crossref","unstructured":"<i>Lankisch, P. G., L\u00f6hr-Happe, A., Otto, J., et al.:<\/i> Natural course in chronic pancreatitis. Pain, exocrine and endocrine pancreatic insufficiency and prognosis of the disease. Digestion, 1993, <i>54<\/i>(3), 148\u2013155.","DOI":"10.1159\/000201029"},{"key":"6","doi-asserted-by":"crossref","unstructured":"<i>Gastard, J., Joubaud, F., Farbos, T., et al.:<\/i> Etiology and course of primary chronic pancreatitis in Western France. Digestion, 1973, <i>9<\/i>(5), 416\u2013428.","DOI":"10.1159\/000197470"},{"key":"7","unstructured":"<i>Lowenfels, A. B., Maisonneuve, P., Cavallini, G., et al.:<\/i> Prognosis of chronic pancreatitis: an international multicenter study. International Pancreatitis Study Group. Am. J. Gastroenterol., 1994, <i>89<\/i>(9), 1467\u20131471."},{"key":"8","doi-asserted-by":"crossref","unstructured":"<i>Maisonneuve, P., Lowenfels, A. B., M\u00fcllhaupt, B., et al.:<\/i> Cigarette smoking accelerates progression of alcoholic chronic pancreatitis. Gut, 2005, <i>54<\/i>(4), 510\u2013514.","DOI":"10.1136\/gut.2004.039263"},{"key":"9","doi-asserted-by":"crossref","unstructured":"<i>Howes, N., Lerch, M. M., Greenhalf, W., et al.:<\/i> Clinical and genetic characteristics of hereditary pancreatitis in Europe. Clin. Gastroenterol. Hepatol., 2004, <i>2<\/i>(3), 252\u2013261.","DOI":"10.1016\/S1542-3565(04)00013-8"},{"key":"10","doi-asserted-by":"crossref","unstructured":"<i>Rebours, V., Boutron-Ruault, M. C., Schnee, M., et al.:<\/i> The natural history of hereditary pancreatitis: a national series. Gut, 2009, <i>58<\/i>(1), 97\u2013103.","DOI":"10.1136\/gut.2008.149179"},{"key":"11","doi-asserted-by":"crossref","unstructured":"<i>Weiss, F. U., Simon, P., Bogdanova, N., et al.:<\/i> Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls. Gut, 2005, <i>54<\/i>(10), 1456\u20131460.","DOI":"10.1136\/gut.2005.064808"},{"key":"12","doi-asserted-by":"crossref","unstructured":"<i>Ellis, I., Lerch, M. M., Whitcomb, D. C.:<\/i> Genetic testing for hereditary pancreatitis: guidelines for indications, counselling, consent and privacy issues. Pancreatology, 2001, <i>1<\/i>(5), 405\u2013415.","DOI":"10.1159\/000055840"},{"key":"13","doi-asserted-by":"crossref","unstructured":"<i>DiMagno, E. P., Go, V. L., Summerskill, W. H.:<\/i> Relations between pancreatic enzyme ouputs and malabsorption in severe pancreatic insufficiency. N. Engl. J. Med., 1973, <i>288<\/i>(16), 813\u2013815.","DOI":"10.1056\/NEJM197304192881603"},{"key":"14","doi-asserted-by":"crossref","unstructured":"<i>Dumasy, V., Delhaye, M., Cotton, F., et al.:<\/i> Fat malabsorption screening in chronic pancreatitis. Am. J. Gastroenterol., 2004, <i>99<\/i>(7), 1350\u20131354.","DOI":"10.1111\/j.1572-0241.2004.30661.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"<i>Siegmund, E., L\u00f6hr, J. M., Schuff-Werner, P.:<\/i> The diagnostic validity of non-invasive pancreatic function tests \u2013 a meta-analysis. Z. Gastroenterol., 2004, <i>42<\/i>(10), 1117\u20131128.","DOI":"10.1055\/s-2004-813604"},{"key":"16","doi-asserted-by":"crossref","unstructured":"<i>Catalano, M. F., Sahai, A., Levy, M., et al.:<\/i> EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification. Gastrointest. Endosc., 2009, <i>69<\/i>(7), 1251\u20131261.","DOI":"10.1016\/j.gie.2008.07.043"},{"key":"17","doi-asserted-by":"crossref","unstructured":"<i>Lerch, M. M., Stier, A., Wahnschaffe, U., et al.:<\/i> Pancreatic pseudocysts: observation, endoscopic drainage, or resection? Dtsch. Arztebl. Int., 2009, <i>106<\/i>(38), 614\u2013621.","DOI":"10.3238\/arztebl.2009.0614"},{"key":"18","doi-asserted-by":"crossref","unstructured":"<i>Cahen, D. L., Gouma, D. J., Nio, Y., et al.:<\/i> Endoscopic versus surgical drainage of the pancreatic duct in chronic pancreatitis. N. Engl. J. Med., 2007, <i>356<\/i>(7), 676\u2013684.","DOI":"10.1056\/NEJMoa060610"},{"key":"19","doi-asserted-by":"crossref","unstructured":"<i>Neoptolemos, J. P., Stocken, D. D., Bassi, C., et al.:<\/i> Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA, 2010, <i>304<\/i>(10), 1073\u2013108.","DOI":"10.1001\/jama.2010.1275"},{"key":"20","doi-asserted-by":"crossref","unstructured":"<i>Varadarajulu, S., Bang, J. Y., Sutton, B. S., et al.:<\/i> Equal efficacy of endoscopic and surgical cystogastrostomy for pancreatic pseudocyst drainage in a randomized trial. Gastroenterology, 2013, <i>145<\/i>(3), 583\u2013590. e1.","DOI":"10.1053\/j.gastro.2013.05.046"},{"key":"21","doi-asserted-by":"crossref","unstructured":"<i>Kahl, S., Zimmermann, S., Genz, I., et al.:<\/i> Risk factors for failure of endoscopic stenting of biliary strictures in chronic pancreatitis: a prospective follow-up study. Am. J. Gastroenterol., 2003, <i>98<\/i>(11), 2448\u20132453.","DOI":"10.1016\/S0002-9270(03)01700-3"},{"key":"22","doi-asserted-by":"crossref","unstructured":"<i>Gouyon, B., L\u00e9vy, P., Ruszniewski, P., et al.:<\/i> Predictive factors in the outcome of pseudocysts complicating alcoholic chronic pancreatitis. Gut, 1997, <i>41<\/i>(6), 821\u2013825.","DOI":"10.1136\/gut.41.6.821"},{"key":"23","doi-asserted-by":"crossref","unstructured":"<i>Bradley, E. L., Clements, J. L. Jr., Gonzalez, A. C.:<\/i> The natural history of pancreatic pseudocysts: a unified concept of management. Am. J. Surg., 1979, <i>137<\/i>(1), 135\u2013141.","DOI":"10.1016\/0002-9610(79)90024-2"},{"key":"24","doi-asserted-by":"crossref","unstructured":"<i>Varadarajulu, S., Christein, J. D., Tamhane, A., et al.:<\/i> Prospective randomized trial comparing EUS and EGD for transmural drainage of pancreatic pseudocysts (with videos). Gastrointest. Endosc., 2008, <i>68<\/i>(6), 1102\u20131111.","DOI":"10.1016\/j.gie.2008.04.028"},{"key":"25","doi-asserted-by":"crossref","unstructured":"<i>Catalano, M. F., Linder, J. D., George, S., et al.:<\/i> Treatment of symptomatic distal common bile duct stenosis secondary to chronic pancreatitis: comparison of single vs. multiple simultaneous stents. Gastrointest. Endosc., 2004, <i>60<\/i>(6), 945\u2013952.","DOI":"10.1016\/S0016-5107(04)02275-8"},{"key":"26","doi-asserted-by":"crossref","unstructured":"<i>Lawrence, C., Romagnuolo, J., Payne, K. M., et al.:<\/i> Low symptomatic premature stent occlusion of multiple plastic stents for benign biliary strictures: comparing standard and prolonged stent change intervals. Gastrointest. Endosc., 2010, <i>72<\/i>(3), 558\u2013563.","DOI":"10.1016\/j.gie.2010.05.029"},{"key":"27","doi-asserted-by":"crossref","unstructured":"<i>Van der Gaag, N. A., Rauws, E. A., van Eijck, C. H., et al.:<\/i> Preoperative biliary drainage for cancer of the head of the pancreas. N. Engl. J. Med., 2010, <i>362<\/i>(2), 129\u2013137.","DOI":"10.1056\/NEJMoa0903230"},{"key":"28","doi-asserted-by":"crossref","unstructured":"<i>Bloechle, C., Izbicki, J. R., Knoefel, W. T., et al.:<\/i> Quality of life in chronic pancreatitis \u2013 results after duodenum-preserving resection of the head of the pancreas. Pancreas, 1995, <i>11<\/i>(1), 77\u201385.","DOI":"10.1097\/00006676-199507000-00008"},{"key":"29","doi-asserted-by":"crossref","unstructured":"<i>Keller, J., Layer, P.:<\/i> Human pancreatic exocrine response to nutrients in health and disease. Gut, 2005, <i>54<\/i>(Suppl. 6), vi1\u2013vi28.","DOI":"10.1136\/gut.2005.065946"},{"key":"30","doi-asserted-by":"crossref","unstructured":"<i>Birkmeyer, J. D., Siewers, A. E., Finlayson, E. V., et al.:<\/i> Hospital volume and surgical mortality in the United States. N. Engl. J. Med., 2002, <i>346<\/i>(15), 1128\u20131137.","DOI":"10.1056\/NEJMsa012337"},{"key":"31","doi-asserted-by":"crossref","unstructured":"<i>B\u00fcchler, M. W., Warshaw, A. L.:<\/i> Resection versus drainage in treatment of chronic pancreatitis. Gastroenterology, 2008, <i>134<\/i>(5), 1605\u20131607.","DOI":"10.1053\/j.gastro.2008.03.029"},{"key":"32","doi-asserted-by":"crossref","unstructured":"<i>Balcom, J. H., Rattner, D. W., Warshaw, A. L., et al.:<\/i> Ten-year experience with 733 pancreatic resections: changing indications, older patients, and decreasing length of hospitalization. Arch. Surg., 2001, <i>136<\/i>(4), 391\u2013398.","DOI":"10.1001\/archsurg.136.4.391"},{"key":"33","doi-asserted-by":"crossref","unstructured":"<i>B\u00fcchler, M. W., Wagner, M., Schmied, B. M., et al.:<\/i> Changes in morbidity after pancreatic resection: toward the end of completion pancreatectomy. Arch. Surg., 2003, <i>138<\/i>(12), 1310\u20131314. Discussion 1315.","DOI":"10.1001\/archsurg.138.12.1310"},{"key":"34","doi-asserted-by":"crossref","unstructured":"<i>Lowenfels, A. B., Sullivan, T., Fiorianti, J., et al.:<\/i> The epidemiology and impact of pancreatic diseases in the United States. Curr. Gastroenterol. Rep., 2005, <i>7<\/i>(2), 90\u201395.","DOI":"10.1007\/s11894-005-0045-6"}],"container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/OH.2015.30060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T22:25:28Z","timestamp":1651184728000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/doi\/10.1556\/oh.2015.30060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1556\/OH.2015.30060"],"URL":"https:\/\/doi.org\/10.1556\/oh.2015.30060","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}