{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T01:29:25Z","timestamp":1649122165788},"reference-count":6,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T00:00:00Z","timestamp":1296432000000},"content-version":"unspecified","delay-in-days":760,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MRS Proc."],"published-print":{"date-parts":[[2009]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The possibility of using three dimensional porous networks as microreactors for synthesizing thermoresponsive polymers and hydrogels in a CO<jats:sub>2<\/jats:sub> environment is an important breakthrough in the strategies to prepare smart films, membranes and porous bulky devices that undergo fast reversible changes in surface properties triggered by external stimuli. <jats:italic>In situ<\/jats:italic> synthesis of thermoresponsive polymers namely, poly(N-isopropylacrylamide) (PNIPAAm) and poly (N,N-diethylacrylamide) (PDEAAm) within chitosan (CHT), collagen (CLG) and chitosan-collagen (CHT:CLG) blended scaffolds were performed in order to further impregnate with model drugs. The performance of these switchable release devices was evaluated through the study of drug release kinetics as a function of temperature and pH. The same methodology was successfully applied to produce thermoresponsive polysulfone-based membranes.<\/jats:p>","DOI":"10.1557\/proc-1220-bb01-07","type":"journal-article","created":{"date-parts":[[2010,1,14]],"date-time":"2010-01-14T14:53:24Z","timestamp":1263480804000},"source":"Crossref","is-referenced-by-count":0,"title":["Development of Switchable \u201cSmart\u201d Biomaterials Using an Environmental Friendly Technology"],"prefix":"10.1557","volume":"1220","author":[{"given":"Telma","family":"Barroso","sequence":"first","affiliation":[]},{"given":"Raquel","family":"Viveiros","sequence":"additional","affiliation":[]},{"given":"Eunice","family":"Costa","sequence":"additional","affiliation":[]},{"given":"M\u00e1rcio","family":"Temtem","sequence":"additional","affiliation":[]},{"given":"Teresa","family":"Casimiro","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Aguiar-Ricardo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2011,1,31]]},"reference":[{"key":"S1946427400019126_ref004","doi-asserted-by":"publisher","DOI":"10.1039\/b821495f"},{"key":"S1946427400019126_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00011-3"},{"key":"S1946427400019126_ref005","first-page":"287","volume":"18","author":"Yeo","year":"2005","journal-title":"Biomaterials"},{"key":"S1946427400019126_ref003","doi-asserted-by":"publisher","DOI":"10.1039\/B603930H"},{"key":"S1946427400019126_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2007.07.012"},{"key":"S1946427400019126_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2008.07.013"}],"container-title":["MRS Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1946427400019126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T20:17:03Z","timestamp":1614197823000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1557\/PROC-1220-BB01-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":6,"alternative-id":["S1946427400019126"],"URL":"https:\/\/doi.org\/10.1557\/proc-1220-bb01-07","relation":{},"ISSN":["0272-9172","1946-4274"],"issn-type":[{"value":"0272-9172","type":"print"},{"value":"1946-4274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]},"article-number":"1220-BB01-07"}}