{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:10:41Z","timestamp":1747199441640,"version":"3.40.5"},"reference-count":0,"publisher":"University of Rzeszow","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Exp Med"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Introduction. Reports continue to show that a significant association exists between serum vitamin D level and metabolic syndrome (MS)-associated inflammation. However, information on the serum levels of vitamin D and alterations in inflammation in different vitamin D status is presently lacking. Aim. To determine the serum levels of vitamin D and TNF-\u03b1, and assess their possible relationship with gender in individuals with MS. Material and methods. Sixty adults with MS and 40 controls were enrolled into this case-control study. Serum vitamin D and TNF-\u03b1 levels were measured and participants stratified into different vitamin D status. Results. None of the participants had vitamin D deficiency and the mean vitamin D level was similar in MS compared with the controls. However, TNF-\u03b1 level was significantly higher in MS compared with the controls. Serum vitamin D level had significant inverse correlation with serum TNF-\u03b1 level in MS. Also vitamin D level was significantly lower while TNF-\u03b1 level was significantly higher in female-MS compared with the male-MS. Conclusion. Adults with MS have elevated TNF-\u03b1 level which appears to be associated with the serum level of vitamin D. Also, females with MS have low vitamin D level and this may exacerbate the MS-associated inflammation in them.<\/jats:p>","DOI":"10.15584\/ejcem.2021.4.3","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T08:57:04Z","timestamp":1649408224000},"page":"306-312","source":"Crossref","is-referenced-by-count":1,"title":["Serum levels of vitamin D and tumour necrosis factor-alpha in adults with metabolic syndrome"],"prefix":"10.15584","volume":"19","author":[{"name":"Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-5026","authenticated-orcid":false,"given":"Sheu Kadiri","family":"Rahamon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Immunology, College of Medicine, University of Ibadan, Ibadan, Nigeria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7901-1498","authenticated-orcid":false,"given":"Olatunbosun Ganiyu","family":"Arinola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Immunology, College of Medicine, University of Ibadan, Ibadan, Nigeria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1208-0047","authenticated-orcid":false,"given":"Mabel Ayebatonyo","family":"Charles-Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9413-3562","authenticated-orcid":false,"given":"Kehinde Sola","family":"Akinlade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0048-0337","authenticated-orcid":false,"given":"John Ayodele","family":"Olaniyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Department of Haematology, College of Medicine, University of Ibadan, Ibadan, 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