{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:52:03Z","timestamp":1793505123785,"version":"4.5.0"},"reference-count":24,"publisher":"Centers for Disease Control MMWR Office","issue":"32","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MMWR Morb. Mortal. Wkly. Rep."],"DOI":"10.15585\/mmwr.mm7432a3","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:08:41Z","timestamp":1756382921000},"page":"508-514","source":"Crossref","is-referenced-by-count":74,"title":["Use of Clesrovimab for Prevention of Severe Respiratory Syncytial Virus\u2013Associated Lower Respiratory Tract Infections in Infants: Recommendations of the Advisory Committee on Immunization Practices \u2014 United States, 2025"],"prefix":"10.15585","volume":"74","author":[{"given":"Danielle L.","family":"Moulia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Link-Gelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Y.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Jamieson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Shay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mila M.","family":"Prill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebony S.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael R.","family":"Ortega-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"MacNeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith L.","family":"McMorrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson M.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6224","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R1","doi-asserted-by":"publisher","first-page":"S154","DOI":"10.1093\/infdis\/jiac120","article-title":"Respiratory syncytial virus is the leading cause of United States infant hospitalizations, 2009\u20132019: a study of the national (nationwide) inpatient sample.","volume":"226","author":"Suh","year":"2022","journal-title":"J Infect Dis"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R2","doi-asserted-by":"publisher","first-page":"e2023065623","DOI":"10.1542\/peds.2023-065623","article-title":"Respiratory syncytial virus\u2013associated hospitalizations in children <5 years: 2016\u20132022.","volume":"154","author":"McMorrow","year":"2024","journal-title":"Pediatrics"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R3","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1056\/NEJMoa0804877","article-title":"The burden of respiratory syncytial virus infection in young children.","volume":"360","author":"Hall","year":"2009","journal-title":"N Engl J Med"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R4","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1093\/infdis\/jiaa752","article-title":"Respiratory syncytial virus\u2013associated hospitalization rates among US infants: a systematic review and meta-analysis.","volume":"225","author":"McLaughlin","year":"2022","journal-title":"J Infect Dis"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R5","doi-asserted-by":"publisher","first-page":"e220527","DOI":"10.1001\/jamanetworkopen.2022.0527","article-title":"Mortality associated with influenza and respiratory syncytial virus in the US, 1999\u20132018.","volume":"5","author":"Hansen","year":"2022","journal-title":"JAMA Netw Open"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R6","doi-asserted-by":"publisher","first-page":"e2023062574","DOI":"10.1542\/peds.2023-062574","article-title":"Respiratory syncytial virus\u2013associated hospitalizations among children <5 years old: 2016 to 2020.","volume":"153","author":"Curns","year":"2024","journal-title":"Pediatrics"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R7","doi-asserted-by":"publisher","first-page":"e341","DOI":"10.1542\/peds.2013-0303","article-title":"Respiratory syncytial virus\u2013associated hospitalizations among children less than 24 months of age.","volume":"132","author":"Hall","year":"2013","journal-title":"Pediatrics"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R8","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.15585\/mmwr.mm7241e1","article-title":"Use of the Pfizer respiratory syncytial virus vaccine during pregnancy for the prevention of respiratory syncytial virus\u2013associated lower respiratory tract disease in infants: recommendations of the Advisory Committee on Immunization Practices\u2014United States, 2023.","volume":"72","author":"Fleming-Dutra","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R9","unstructured":"MacNeil A. CDC. Effectiveness and impact of RSV prevention products in infants during the 2024\u20132025 RSV season. [Presentation slides]. Presented at the Advisory Committee on Immunization Practices meeting, Atlanta, GA; June 26, 2025. https:\/\/www.cdc.gov\/acip\/downloads\/slides-2025-06-25-26\/03-MacNeil-Mat-Peds-RSV-508.pdf"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R10","doi-asserted-by":"publisher","first-page":"273","DOI":"10.15585\/mmwr.mm7416a1","article-title":"Interim evaluation of respiratory syncytial virus hospitalization rates among infants and young children after introduction of respiratory syncytial virus prevention products\u2014United States, October 2024\u2013February 2025.","volume":"74","author":"Patton","year":"2025","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R11","unstructured":"Food and Drug Administration. Enflonsia (clesrovimab-cfof) [Package insert]. Silver Spring, MD: US Department of Health and Human Services, Food and Drug Administration; 2025. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2025\/761432s000lbl.pdf"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R12","unstructured":"CDC. Grading of recommendations, assessment, development, and evaluation (GRADE): clesrovimab. Atlanta, GA: US Department of Health and Human Services, CDC; 2023. https:\/\/www.cdc.gov\/acip\/grade\/clesrovimab-infants.html"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R13","unstructured":"CDC. ACIP evidence to recommendations for use of clesrovimab in infants born during RSV season and entering their first RSV season. Atlanta, GA: US Department of Health and Human Services, CDC; 2023. https:\/\/www.cdc.gov\/acip\/evidence-to-recommendations\/clesrovimab-infants.html"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R14","unstructured":"Moulia DL;CDC. Maternal and pediatric RSV work group interpretations and next steps. [Presentation slides]. Presented at the Advisory Committee on Immunization Practices meeting, Atlanta, GA; October 23, 2024. https:\/\/www.cdc.gov\/acip\/downloads\/slides-2024-10-23-24\/04-RSV-Mat-Peds-Moulia-508.pdf"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R15","unstructured":"Moulia DL;CDC. Evidence to recommendations framework: clesrovimab. [Presentation slides]. Presented at the Advisory Committee on Immunization Practices meeting, Atlanta, GA; April 16, 2025. https:\/\/www.cdc.gov\/acip\/downloads\/slides-2025-04-15-16\/02-Moulia-maternal-peds-RSV-508.pdf"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R16","unstructured":"MacNeil A;CDC. Updates on evidence to recommendations framework: clesrovimab. [Presentation slides]. Presented at the Advisory Committee on Immunization Practices meeting, Atlanta, GA; June 26, 2025. https:\/\/www.cdc.gov\/acip\/downloads\/slides-2025-06-25-26\/05-MacNeil-Mat-Peds-RSV-508.pdf"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R17","unstructured":"Sinha A. Merck. Clesrovimab (MK-1654): Pediatric clinical program. [Presentation slides]. Presented at the Advisory Committee on Immunization Practices meeting, Atlanta, GA; October 23, 2024. https:\/\/www.cdc.gov\/acip\/downloads\/slides-2024-10-23-24\/02-RSV-Mat-Peds-Sinha-508.pdf"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R18","unstructured":"Food and Drug Administration, Center for Drug Evaluation and Research. Integrated review of clesrovimab application. Silver Spring, MD: US Department of Health and Human Services, Food and Drug Administration; 2025. \u2028https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2025\/761432Orig1s000IntegratedR.pdf"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R19","doi-asserted-by":"publisher","first-page":"e2024066461","DOI":"10.1542\/peds.2024-066461","article-title":"Cost-effectiveness of nirsevimab for respiratory syncytial virus in infants and young children.","volume":"154","author":"Hutton","year":"2024","journal-title":"Pediatrics"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R20","doi-asserted-by":"publisher","first-page":"355","DOI":"10.15585\/mmwr.mm7214a1","article-title":"Seasonality of respiratory syncytial virus\u2014United States, 2017\u20132023.","volume":"72","author":"Hamid","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/ice.2025.88","article-title":"Respiratory syncytial virus: an under-recognized healthcare-associated infection.","volume":"46","author":"Gettler","year":"2025","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R22","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1542\/peds.100.6.943","article-title":"Nosocomial respiratory syncytial virus infection in Canadian pediatric hospitals: a Pediatric Investigators Collaborative Network on Infections in Canada Study.","volume":"100","author":"Langley","year":"1997","journal-title":"Pediatrics"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R23","doi-asserted-by":"crossref","unstructured":"Kimberlin DW, Banerjee R, Barnett ED, eds. Respiratory Syncytial Virus [Section 3]. In: Red Book: 2024\u20132027 Report of the Committee on Infectious Diseases, 32nd ed.; 2024. https:\/\/publications.aap.org\/redbook\/book\/755\/Red-Book-2024-2027-Report-of-the-Committee-on?autologincheck=redirected","DOI":"10.1542\/9781610027373"},{"key":"key-10.15585\/mmwr.mm7432a3-202508280808-R24","unstructured":"MacNeil A. Work group considerations and clinical considerations for clesrovimab. [Presentation slides]. Presented at the Advisory Committee on Immunization Practices meeting, Atlanta, GA; June 26, 2025. https:\/\/www.cdc.gov\/acip\/downloads\/slides2025-06-25-26\/06-MacNeil-Mat-Peds-RSV-508.pdf"}],"container-title":["MMWR. Morbidity and Mortality Weekly Report"],"original-title":[],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:08:43Z","timestamp":1756382923000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.cdc.gov\/mmwr\/volumes\/74\/wr\/mm7432a3.htm?s_cid=mm7432a3_w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":24,"journal-issue":{"issue":"32","published-online":{"date-parts":[[2025,8,28]]}},"URL":"https:\/\/doi.org\/10.15585\/mmwr.mm7432a3","relation":{},"ISSN":["0149-2195","1545-861X"],"issn-type":[{"value":"0149-2195","type":"print"},{"value":"1545-861X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,8,28]]},"published":{"date-parts":[[2025,8,28]]}}}