{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T17:09:22Z","timestamp":1719940162282},"reference-count":0,"publisher":"Codon Publications","issue":"2","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["aei"],"abstract":"<jats:p>Introduction and objectives: Relationship between the causal mechanisms of pediatric severe asthma and severity of symptoms would be helpful for developing personalized strategies for treatment and prevention.Materials and methods: For this study, 698 medical histories of asthmatics between 6 and 18 years of age were reviewed in a period of 2 years. Variables analyzed were: age, sex, ethnicity, perinatological history, allergy history, asthma predictive index (API), exposure to tobacco, heavy traffic or epithelium, lung function, age of onset of symptoms, hospitalization admissions\/PICU, systemic corticosteroids, daily symptoms control, device prescribe for daily control, and adherence.Results: A total of 86 children with severe asthma were included (12.3%). Mean age 13.3 +\/\u2212 1.86 years, sex ratio1:1, mean age of symptom onset 2.765 +\/\u2212 3.06 years, mean IgE 1076.18KU \/ L +\/\u2212 1136, mean eosinophils 604c \/ mcl +\/\u2212 511.9, mean of FEV1 93.15% +\/\u2212 16.3. Evidently, 70 children (81.4%) had positive API, 68 (79.1%) rhinitis, 34 (39.5%) atopic dermatitis. 73 (83.9%) sensitized to inhalants and 56 (65.1%) to dermatophagoides, 39 (45.3%) passive smokers, 19 (22.1%) exposure to heavy traffic; 55 (64%) showed symptoms with exercise, 35 (40.7%) had audible wheezing. The mean systemic corticosteroid cycles\/year was 3.63 +\/\u2212 3.23, mean PICU admissions 0.36 +\/\u2212 0.83, mean hospital admissions 4.31 +\/\u2212 5.3, average emergency room visits\/year 19.44 +\/\u2212 16.28. 38 (56.7%) had good adherence, 44 (51%) used an MDI device and 39 (45.3%) used dry powder.Conclusions: Children with severe asthma meet the following criteria: premature, positive API, rhinitis, atopic dermatitis, high IgE, eosinophilia, passive smokers, exposure to heavy traffic, decreased lung function, and low adherence to controller medication.<\/jats:p>","DOI":"10.15586\/aei.v49i2.65","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T07:19:35Z","timestamp":1614669575000},"page":"60-65","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of severe asthma in the pediatric population"],"prefix":"10.15586","volume":"49","author":[{"given":"Amalui","family":"Vasquez Perez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Bob\u00e9","family":"Pol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Rua Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Garc\u00eda Lorenzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Gomez Serra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Bosque-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6228","published-online":{"date-parts":[[2021,3,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"http:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/65\/264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/65\/265","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/65\/266","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/65\/264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T07:19:40Z","timestamp":1614755980000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.all-imm.com\/index.php\/aei\/article\/view\/65"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v49i2.65","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]}}}