{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:01:29Z","timestamp":1767909689543,"version":"3.49.0"},"reference-count":0,"publisher":"Codon Publications","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Objective: Long intergenic noncoding RNA 00632 (LINC00632) regulates nasal inflammation and CD4+\u00a0T cell differentiation into T helper (Th) 2 cells in allergic rhinitis (AR). This study aimed to explore the relationship between LINC00632 and Th1\/Th2 balance, and the clinical value of LINC00632 in AR patients.\nMethods: In total, 120 AR patients, 20 non-atopic obstructive snoring patients as disease controls (DCs), and 20 healthy controls (HCs) were recruited. Their LINC00632 expressions in peripheral blood mononuclear cells were detected by RT-qPCR.\nResults: LINC00632 expression was declined in AR patients compared with DCs and HCs (both\u00a0P\u00a0\u02c2 0.001). Moreover, LINC00632 could distinguish AR patients from DCs with an area under curve (AUC) of 0.795 (95% confidence interval [CI]: 0.701\u20130.889), and from HCs with an AUC of 0.895 (95%CI: 0.831\u20130.960). LINC00632 was positively related to Th1 cells (P\u00a0= 0.037) and Th1\/Th2 axis (P\u00a0\u02c2 0.001) in AR patients. In addition, LINC00632 was inversely associated with Th2 cells (P\u00a0\u02c2 0.001) and interleukin (IL)-4 (P\u00a0= 0.010) in AR patients. Besides, LINC00632 was negatively related to rhinorrhea score (P\u00a0= 0.019), itching score (P\u00a0= 0.008), sneezing score (P\u00a0= 0.004), and total nasal symptom score (TNSS) (P\u00a0\u02c2 0.001), but no correlation between LINC00632 and congestion score was observed (P\u00a0= 0.093). During treatment, LINC00632 was elevated, while TNSS score was reduced (both\u00a0P\u00a0\u02c2 0.001). Furthermore, LINC00632 increment was associated with the reduction of TNSS score during the therapy (P\u00a0= 0.005).\nConclusion: LINC00632 relates to milder Th1\/Th2 imbalance, attenuated nasal symptoms, and better response during 4-week therapy in AR patients.<\/jats:p>","DOI":"10.15586\/aei.v51i2.728","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T12:54:55Z","timestamp":1678107295000},"page":"120-125","source":"Crossref","is-referenced-by-count":4,"title":["LINC00632 relates to milder Th1\/Th2 imbalance, attenuated nasal symptoms, and better response to therapy in allergic rhinitis patients"],"prefix":"10.15586","volume":"51","author":[{"given":"Yanan","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guimin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengchi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaobo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6228","published-online":{"date-parts":[[2023,3,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/728\/1216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/728\/1218","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/728\/1217","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/728\/1216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T12:54:56Z","timestamp":1678107296000},"score":1,"resource":{"primary":{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/view\/728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,3,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v51i2.728","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,1]]}}}