{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:14:17Z","timestamp":1791976457066,"version":"4.4.0"},"reference-count":0,"publisher":"Codon Publications","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Background: Hypersensitivity reactions (HSRs) to nonsteroidal anti-inflammatory drugs (NSAIDs) are a significant clinical issue. Several classifications have been proposed to categorize these reactions, including the current European Academy of Allergy and Clinical Immunology\/ European Network for Drug Allergy (EAACI\/ENDA) classification. This study aimed to evaluate the applicability of this classification in a real-world clinical setting.\nMethods: We conducted a national multicenter study involving patients from nine hospitals in four major urban centers in Turkey. All patients had a suggestive clinical history of hypersen-sitivity reactions to NSAIDs. Researchers collected data using a structured form and classified reactions based on the EAACI\/ENDA classification. Oral provocation tests with several NSAIDs were performed using a single-blind challenge per EAACI\/ENDA guidelines.\nResults: Our retrospective study included 966 adult patients with a history of hypersensitivity to NSAIDs. The most common triggers were Acetylsalicylic Acid (ASA), paracetamol, and metamizole. The most prevalent acute NSAID hypersensitivity group was NSAID-induced urticaria\/angioedema (NIUA) (34.3%). However, 17.3% of patients did not fit neatly into the current EAACI\/ENDA classification. Notably, patients with underlying asthma or allergic rhinoconjunctivitis exhibited unusual reactions, such as urticaria and\/or angioedema induced by multiple chemical groups of NSAIDs, blended mixed reactions, and isolated periorbital angioedema in response to multiple chemical groups of NSAIDs.\nConclusions: While the EAACI\/ENDA classification system stratifies NSAID-induced hypersensitivity reactions into five distinct endotypes or phenotypes, it may not fully capture the diversity of these reactions. Our findings suggest a need for further research to refine this classification system and better accommodate patients with atypical presentations.<\/jats:p>","DOI":"10.15586\/aei.v51i5.946","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T16:34:41Z","timestamp":1693586081000},"page":"84-92","source":"Crossref","is-referenced-by-count":13,"title":["Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs in adults"],"prefix":"10.15586","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0844-6352","authenticated-orcid":false,"given":"Pamir","family":"\u00c7er\u00e7i","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8322-846X","authenticated-orcid":false,"given":"Resat","family":"Kendirlinan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1899-5566","authenticated-orcid":false,"given":"Suna","family":"B\u00fcy\u00fck\u00f6zt\u00fcrk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3524-9952","authenticated-orcid":false,"given":"Asl\u0131","family":"Gelincik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"\u00dcnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3449-5868","authenticated-orcid":false,"given":"Semra","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9155-0304","authenticated-orcid":false,"given":"Ferda","family":"\u00d6ner Erkekol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-091X","authenticated-orcid":false,"given":"G\u00fcl","family":"Karakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6337-6326","authenticated-orcid":false,"given":"Adile Berna","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serhat","family":"\u00c7elikel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2954-4293","authenticated-orcid":false,"given":"Dane","family":"Ediger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9504-7412","authenticated-orcid":false,"given":"Oznur","family":"Abadoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7884-0830","authenticated-orcid":false,"given":"Sevim","family":"Bavbek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","published-online":{"date-parts":[[2023,9,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/946\/1432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/946\/1433","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/946\/1434","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/946\/1432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T16:34:59Z","timestamp":1693672499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/view\/946"}},"subtitle":["Beyond current classification"],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v51i5.946","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,1]]}}}