{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:07:59Z","timestamp":1768889279704,"version":"3.49.0"},"reference-count":0,"publisher":"Codon Publications","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Objective: To evaluate the relationship between the occurrence of contact urticaria in reaction to cow\u2019s milk in infants and the diagnosis of cow\u2019s milk allergy (CMA) established by supervised oral food challenge.\nMethods: In this cross-sectional study, we identified 184 children who had undergone 221 oral food challenge (OFC) at a CMA reference center between July 2015 and August 2019. Of these, 23 (12.5%) had a history of contact urticaria to cow\u2019s milk and underwent a total of 30 OFC. Baked cow\u2019s milk OFC were excluded, and 21 children were included in the study. All data from clinical history and allergy tests (serum-specific IgE dosages and skin prick test [SPT] with reconstituted cow\u2019s milk formula) were recorded on standardized forms. The challenge was conducted with reconstituted cow\u2019s milk formula in increasing volumes every 15\u201320 min.\nResults: 24 OFC were performed; 13\/24 (54.2%) for diagnostic purpose and 11\/24 (45.8%) to evaluate cow\u2019s milk tolerance. Allergy tests were positive in 14 patients (87.5%). Positive oral challenge outcomes were identified in 7\/24. One patient had a late flare of atopic dermatitis and five children presented with immediate urticaria (two generalized urticaria and three perioral urticaria). The median papule diameter was 6.5 mm in patients with a positive OFC and 3.75 mm in the negative group (P = 0.02).\nConclusion: The occurrence of contact urticaria might be the only manifestation among infants sensitized to cow\u2019s milk with tolerance to oral ingestion. Reactions due to oral challenge were related to a larger wheal diameter on the SPT.<\/jats:p>","DOI":"10.15586\/aei.v51i5.947","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T20:34:31Z","timestamp":1693600471000},"page":"93-98","source":"Crossref","is-referenced-by-count":3,"title":["Oral food challenge in children with contact urticaria in reaction to cow\u2019s milk"],"prefix":"10.15586","volume":"51","author":[{"given":"Manuela","family":"Coimbra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Maria","family":"Lacerda Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8550-8051","authenticated-orcid":false,"given":"Nelson Augusto","family":"Ros\u00e1rio Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6228","published-online":{"date-parts":[[2023,9,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/947\/1435","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/947\/1436","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/947\/1437","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/download\/947\/1435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T20:34:51Z","timestamp":1693686891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.all-imm.com\/index.php\/aei\/article\/view\/947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v51i5.947","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,1]]}}}