{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:06:22Z","timestamp":1788815182849,"version":"build-2803163510"},"reference-count":0,"publisher":"Codon Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Background: Antituberculosis drugs can cause hypersensitivity reactions that interrupt treatment and increase morbidity. Early identification and management are essential to prevent complications and drug resistance.\nObjective: To evaluate the clinical characteristics, risk factors, and outcomes of antituberculosis drug\u2013induced hypersensitivity reactions over a 10-year period in a tertiary referral center.\nMethods: We retrospectively analyzed 449 patients hospitalized for antituberculosis drug\u2013induced hypersensitivity between 2015 and 2024. A control group of 478 tuberculosis patients without hypersensitivity was included. Demographic features, comorbidities, hypersensitivity types, causative drugs, and treatment outcomes were compared.\nResults: The prevalence of hypersensitivity was 12.1%. Female gender, older age, Turkish nationality, and history of other drug allergies were significant risk factors. Type 1 reactions (77.7%) were more common and associated with shorter treatment interruption and higher cure rates. Pyrazinamide was the most frequently implicated drug. Desensitization was successful in the majority of patients.\nConclusion: This large cohort study highlights key risk factors and clinical outcomes in tuberculosis drug hypersensitivity. Close monitoring of high-risk patients in the early treatment phase may reduce delays and improve outcomes.<\/jats:p>","DOI":"10.15586\/aei.v53i5.1427","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T13:49:48Z","timestamp":1756734588000},"page":"69-77","source":"Crossref","is-referenced-by-count":2,"title":["Antituberculosis drug\u2013induced hypersensitivity: clinical characteristics and risk factors"],"prefix":"10.15586","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6858-6824","authenticated-orcid":false,"given":"Zeynep","family":"Yegin Katran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smet","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aylin","family":"Babal\u0131k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Keren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Merve Tepetam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","published-online":{"date-parts":[[2025,9,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1427\/2058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1427\/2059","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1427\/2060","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1427\/2058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T09:53:57Z","timestamp":1757238837000},"score":1,"resource":{"primary":{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/view\/1427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v53i5.1427","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,1]]}}}