{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T13:40:48Z","timestamp":1767793248262,"version":"3.49.0"},"reference-count":0,"publisher":"Codon Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Background: Bronchial asthma (BA) frequently coexists with obstructive sleep apnea syndrome (OSAS). The obesity\u2013inflammation axis may underlie this overlap, but pragmatic predictors and biomarker utility remain incompletely defined.\nObjective: To identify clinical predictors of OSAS in BA and evaluate the diagnostic performance of leptin (LEP), interleukin-6 (IL-6), and neutrophil-to-lymphocyte ratio (NLR), individually and in combination.\nMaterials and Methods: In a prospective study, 263 adults with BA were enrolled and classified into OSAS (n=124) and non-OSAS (n=139) groups by polysomnography. The OSAS group was stratified by apnea\u2013hypopnea index (AHI) into mild (n=59), moderate (n=42), and severe (n=23). Clinical variables were compared with univariate tests. Independent predictors were identified using binary logistic regression. Serum LEP and IL-6 (immunoassays) and NLR (hematology) were measured. Biomarker\u2013AHI relationships were assessed by Spearman\u2019s correlation. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curves and DeLong\u2019s test.\nResults: On univariate analysis, OSAS cases were older and more often male, with higher rates of obesity, severe BA, neck circumference &gt;40 cm, rhinitis, and gastroesophageal reflux disease (GERD). Logistic regression confirmed obesity, severe BA, neck circumference &gt;40 cm, rhinitis, and GERD as independent predictors. LEP, IL-6, and NLR were significantly higher in OSAS than non-OSAS and increased progressively across AHI strata. LEP correlated strongly with IL-6, IL-6 with NLR, and LEP with NLR to a lesser extent (all P&lt;0.001). For diagnosing BA\u2013OSAS, AUCs were 0.746 (LEP), 0.771 (IL-6), 0.742 (NLR), and 0.826 for their combination, which outperformed individual markers (DeLong, P&lt;0.05).\nConclusion: Obesity, neck circumference &gt;40 cm, severe BA, rhinitis, and GERD independently predict OSAS in BA. LEP, IL-6, and NLR correlate with OSAS severity, and their combined use provides superior diagnostic value for identifying BA\u2013OSAS comorbidity and may aid targeted screening and referral. (\u2248240 words)<\/jats:p>","DOI":"10.15586\/aei.v54i1.1473","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T15:07:06Z","timestamp":1767280026000},"page":"96-104","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of obstructive sleep apnea syndrome in bronchial asthma patients: investigating the obesity\u2013inflammation interplay through LEP, IL-6, and NLR"],"prefix":"10.15586","volume":"54","author":[{"given":"Lili","family":"Miao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6228","published-online":{"date-parts":[[2026,1,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1473\/2226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1473\/2227","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1473\/2228","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1473\/2226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T10:16:10Z","timestamp":1767780970000},"score":1,"resource":{"primary":{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/view\/1473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v54i1.1473","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]}}}