{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:14:51Z","timestamp":1767874491521,"version":"3.49.0"},"reference-count":0,"publisher":"Codon Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>ST-elevation myocardial infarction (STEMI) involves the complete blockage of a coronary artery, leading to severe cardiac damage and high mortality. miR-1 promotes cardiomyocyte apoptosis by downregulating the anti-apoptotic protein BCL2, while miR-126-5p negatively regulates\u00a0PIK3R2\u00a0by activating the PI3K\/Akt pathway. The expression of these miRNAs correlates with\u00a0BCL2, PIK3R2, and high-sensitivity cardiac troponin T (hs-cTnT) in patients and controls, highlighting their role in apoptosis and myocardial injury. This study aimed to compare serum levels of miR-1,\u00a0BCL2, microRNA-126-5p (miR-126-5p), Phosphoinositide-3-Kinase Regulatory Subunit 2 (PIK3R2), and cTnT in patients and controls. The association of miR-1 with\u00a0BCL2\u00a0and miR-126-5p with\u00a0PIK3R2\u00a0in STEMI patients was analyzed using ELISA and statistical analysis. Results showed a substantial increase in\u00a0BCL2\u00a0levels in STEMI patients (128.01 \u00b1 137.19) compared to controls (40.65 \u00b1 20.92), and a decrease in miR-1 levels in STEMI patients (31.35 \u00b1 68.89) compared to controls (43.43 \u00b1 31.28). Similarly, the\u00a0PIK3R2\u00a0and miR-126-5p levels among cases and controls were 228.55 \u00b1 127.4 and 0.17 \u00b1 0.32, respectively, showing a significant difference between patients and controls. Statistical analysis revealed that the expression levels of miR-1 and miR-126-5p are significantly different between controls and patients (p-value &lt; 0.05), demonstrating a strong association with the prognosis of ST-elevation myocardial infarction. Moreover, a strong correlation was observed between BCL2 levels and PIK3R2 levels (p-value &lt; 0.05) among STEMI patients. These results establish a profound diagnostic profile for STEMI using miR-1 and miR-126-5p and highlight the functional importance of these miRNAs in angiogenesis by targeting the\u00a0BCL2\u00a0and\u00a0PIK3R2\u00a0proteins.<\/jats:p>","DOI":"10.15586\/aei.v54i1.1520","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T14:56:45Z","timestamp":1767279405000},"page":"154-165","source":"Crossref","is-referenced-by-count":0,"title":["Effect of miR-1 and miR-126-5p in BCL2 and PIK3R2 regulation in apoptotic signaling during ST-elevation myocardial infarction"],"prefix":"10.15586","volume":"54","author":[{"given":"Arshia","family":"Mehmood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almas","family":"Muhammad Arshad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awais","family":"Altaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahir","family":"Maqbool","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafiza","family":"Saba Safdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Faisal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeeha","family":"Shahzad Lodhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawal","family":"Al-Hoshani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maher S.","family":"Alwethaynani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaza N.","family":"Alkhatib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omniah A.","family":"Mansouri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan","family":"Abdulrahman Sagini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6228","published-online":{"date-parts":[[2026,1,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1520\/2244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1520\/2245","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1520\/2246","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1520\/2244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:16:22Z","timestamp":1767867382000},"score":1,"resource":{"primary":{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/view\/1520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v54i1.1520","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]}}}