{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T04:29:40Z","timestamp":1781929780095,"version":"3.54.5"},"reference-count":0,"publisher":"Codon Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Allergol Immunopathol"],"abstract":"<jats:p>Background: Subcutaneous immunotherapy (SCIT) for allergic rhinitis (AR) requires long-term treatment, and its phased efficacy often influences patient adherence. Identifying early biomarkers, such as serum-specific IgE to total IgE (sIgE\/tIgE) ratio, may support individualized management.Objective: To determine the predictive value of baseline double-mite (D1+D2) sIgE\/tIgE ratio for phased dual-mite SCIT response in AR patients.Methods: We prospectively enrolled 194 AR patients sensitized to Dermatophagoides pteronyssinus (D1) and Dermatophagoides farinae (D2) who received dual-mite SCIT between September 2022 and January 2023. Baseline serum tIgE and sIgE (D1+D2) were measured, and the combined sIgE\/tIgE ratio was calculated. Treatment response was evaluated by reduction in visual analogue scale (VAS) scores at months 6 and 12, with the efficacy distribution compared between the two time points using the Chi-square test. Univariable and multivariable logistic regression identified predictors of achieving at least an effective response, and receiver operating characteristic (ROC) analysis was applied for sIgE\/tIgE ratio when indicated.Results: SCIT efficacy improved over time, with a significant shift in response distribution between 6 and 12 months (\u03c7\u00b2 = 10.084, P = 0.006). At 6 months, multivariable analysis showed that both higher baseline VAS score (OR = 0.954, 95% CI: 0.929\u20130.980, P &lt; 0.001) and higher sIgE\/tIgE ratio (OR = 0.985, 95% CI: 0.972\u20130.999, P = 0.036) were independently associated with lower likelihood of achieving at least effective response. ROC analysis indicated a cutoff sIgE\/tIgE ratio of 26.62% for predicting poor short-term response. At month 12, only baseline VAS score remained a significant predictor (OR = 1.038, 95% CI: 1.005\u20131.072, P = 0.025).Conclusion: SCIT efficacy progressively improves over the first year. A higher baseline sIgE (D1+D2)\/tIgE ratio (&gt;26.62%) predicts poorer short-term response, highlighting the value of objective biomarkers for early response assessment and individualized management.<\/jats:p>","DOI":"10.15586\/aei.v54i2.1514","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:11:28Z","timestamp":1772464288000},"page":"164-169","source":"Crossref","is-referenced-by-count":1,"title":["Baseline serum double-mite (D1+D2) sIgE\/tIgE ratio as a predictor of early-phase response to dual-mite subcutaneous immunotherapy in allergic rhinitis"],"prefix":"10.15586","volume":"54","author":[{"given":"Chengzhi","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","published-online":{"date-parts":[[2026,3,1]]},"container-title":["Allergologia et Immunopathologia"],"original-title":[],"link":[{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1514\/2341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1514\/2342","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1514\/2343","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/download\/1514\/2341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:11:28Z","timestamp":1772464288000},"score":1,"resource":{"primary":{"URL":"https:\/\/all-imm.com\/index.php\/aei\/article\/view\/1514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,3,2]]}},"URL":"https:\/\/doi.org\/10.15586\/aei.v54i2.1514","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]}}}